Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Conti, DV
Darst, BF
Moss, LC
Saunders, EJ
Sheng, X
Chou, A
Schumacher, FR
Olama, AAA
Benlloch, S
Dadaev, T
Brook, MN
Zhang, H-W
Feng, N
Mao, X
Wu, Y
Zhao, S-C
Sun, Z
Thibodeau, SN
McDonnell, SK
Schaid, DJ
West, CML
Sahimi, A
Burnet, N
Barnett, G
Maier, C
Schnoeller, T
Luedeke, M
Kibel, AS
Drake, BF
Cussenot, O
Cancel-Tassin, G
Menegaux, F
Hoffmann, TJ
Truong, T
Koudou, YA
John, EM
Grindedal, EM
Maehle, L
Khaw, K-T
Ingles, SA
Stern, MC
Vega, A
Gómez-Caamaño, A
Takahashi, A
Fachal, L
Rosenstein, BS
Kerns, SL
Ostrer, H
Teixeira, MR
Paulo, P
Brandão, A
Watya, S
Lubwama, A
Bensen, JT
Matsuda, K
Fontham, ETH
Mohler, J
Taylor, JA
Kogevinas, M
Llorca, J
Castaño-Vinyals, G
Cannon-Albright, L
Teerlink, CC
Huff, CD
Strom, SS
Momozawa, Y
Multigner, L
Blanchet, P
Brureau, L
Kaneva, R
Slavov, C
Mitev, V
Leach, RJ
Weaver, B
Brenner, H
Cuk, K
Fujita, M
Holleczek, B
Saum, K-U
Klein, EA
Hsing, AW
Kittles, RA
Murphy, AB
Logothetis, CJ
Kim, J
Neuhausen, SL
Steele, L
Muir, K
Ding, YC
Isaacs, WB
Nemesure, B
Hennis, AJM
Carpten, J
Pandha, H
Michael, A
De Ruyck, K
De Meerleer, G
Ost, P
Lophatananon, A
Xu, J
Razack, A
Lim, J
Teo, S-H
Newcomb, LF
Lin, DW
Fowke, JH
Neslund-Dudas, C
Rybicki, BA
Gamulin, M
Wan, P
Lessel, D
Kulis, T
Usmani, N
Singhal, S
Parliament, M
Claessens, F
Joniau, S
Van den Broeck, T
Gago-Dominguez, M
Castelao, JE
Le Marchand, L
Martinez, ME
Larkin, S
Townsend, PA
Aukim-Hastie, C
Bush, WS
Aldrich, MC
Crawford, DC
Srivastava, S
Cullen, JC
Petrovics, G
Wilkens, LR
Casey, G
Roobol, MJ
Jenster, G
van Schaik, RHN
Hu, JJ
Sanderson, M
Varma, R
McKean-Cowdin, R
Torres, M
Mancuso, N
Stevens, VL
Berndt, SI
Van Den Eeden, SK
Easton, DF
Chanock, SJ
Cook, MB
Wiklund, F
Nakagawa, H
Witte, JS
Eeles, RA
Kote-Jarai, Z
Gapstur, SM
Haiman, CA
Carter, BD
Schleutker, J
Tammela, TLJ
Sipeky, C
Auvinen, A
Giles, GG
Southey, MC
MacInnis, RJ
Cybulski, C
Wokołorczyk, D
Lubiński, J
Neal, DE
Donovan, JL
Hamdy, FC
Martin, RM
Nordestgaard, BG
Nielsen, SF
Weischer, M
Bojesen, SE
Røder, MA
Iversen, P
Batra, J
Chambers, S
Moya, L
Horvath, L
Clements, JA
Tilley, W
Risbridger, GP
Gronberg, H
Aly, M
Szulkin, R
Eklund, M
Nordström, T
Pashayan, N
Dunning, AM
Ghoussaini, M
Travis, RC
Key, TJ
Riboli, E
Park, JY
Sellers, TA
Lin, H-Y
Albanes, D
Weinstein, SJ
Mucci, LA
Giovannucci, E
Lindstrom, S
Kraft, P
Hunter, DJ
Penney, KL
Turman, C
Tangen, CM
Goodman, PJ
Thompson, IM
Hamilton, RJ
Fleshner, NE
Finelli, A
Parent, M-É
Stanford, JL
Ostrander, EA
Geybels, MS
Koutros, S
Freeman, LEB
Stampfer, M
Wolk, A
Håkansson, N
Andriole, GL
Hoover, RN
Machiela, MJ
Sørensen, KD
Borre, M
Blot, WJ
Zheng, W
Yeboah, ED
Mensah, JE
Lu, Y-J
- Publisher:
- Nature Research
- Publication Type:
- Journal Article
- Citation:
- Nature Genetics, 2021, 53, (1), pp. 65-75
- Issue Date:
- 2021-01-04
Closed Access
Filename | Description | Size | |||
---|---|---|---|---|---|
s41588-020-00748-0.pdf | Published Version | 12.5 MB | Adobe PDF |
Copyright Clearance Process
- Recently Added
- In Progress
- Closed Access
This item is closed access and not available.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Conti, DV | |
dc.contributor.author | Darst, BF | |
dc.contributor.author | Moss, LC | |
dc.contributor.author | Saunders, EJ | |
dc.contributor.author | Sheng, X | |
dc.contributor.author | Chou, A | |
dc.contributor.author | Schumacher, FR | |
dc.contributor.author | Olama, AAA | |
dc.contributor.author | Benlloch, S | |
dc.contributor.author | Dadaev, T | |
dc.contributor.author | Brook, MN | |
dc.contributor.author | Zhang, H-W | |
dc.contributor.author | Feng, N | |
dc.contributor.author | Mao, X | |
dc.contributor.author | Wu, Y | |
dc.contributor.author | Zhao, S-C | |
dc.contributor.author | Sun, Z | |
dc.contributor.author | Thibodeau, SN | |
dc.contributor.author | McDonnell, SK | |
dc.contributor.author | Schaid, DJ | |
dc.contributor.author | West, CML | |
dc.contributor.author | Sahimi, A | |
dc.contributor.author | Burnet, N | |
dc.contributor.author | Barnett, G | |
dc.contributor.author | Maier, C | |
dc.contributor.author | Schnoeller, T | |
dc.contributor.author | Luedeke, M | |
dc.contributor.author | Kibel, AS | |
dc.contributor.author | Drake, BF | |
dc.contributor.author | Cussenot, O | |
dc.contributor.author | Cancel-Tassin, G | |
dc.contributor.author | Menegaux, F | |
dc.contributor.author | Hoffmann, TJ | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Koudou, YA | |
dc.contributor.author | John, EM | |
dc.contributor.author | Grindedal, EM | |
dc.contributor.author | Maehle, L | |
dc.contributor.author | Khaw, K-T | |
dc.contributor.author | Ingles, SA | |
dc.contributor.author | Stern, MC | |
dc.contributor.author | Vega, A | |
dc.contributor.author | Gómez-Caamaño, A | |
dc.contributor.author | Takahashi, A | |
dc.contributor.author | Fachal, L | |
dc.contributor.author | Rosenstein, BS | |
dc.contributor.author | Kerns, SL | |
dc.contributor.author | Ostrer, H | |
dc.contributor.author | Teixeira, MR | |
dc.contributor.author | Paulo, P | |
dc.contributor.author | Brandão, A | |
dc.contributor.author | Watya, S | |
dc.contributor.author | Lubwama, A | |
dc.contributor.author | Bensen, JT | |
dc.contributor.author | Matsuda, K | |
dc.contributor.author | Fontham, ETH | |
dc.contributor.author | Mohler, J | |
dc.contributor.author | Taylor, JA | |
dc.contributor.author | Kogevinas, M | |
dc.contributor.author | Llorca, J | |
dc.contributor.author | Castaño-Vinyals, G | |
dc.contributor.author | Cannon-Albright, L | |
dc.contributor.author | Teerlink, CC | |
dc.contributor.author | Huff, CD | |
dc.contributor.author | Strom, SS | |
dc.contributor.author | Momozawa, Y | |
dc.contributor.author | Multigner, L | |
dc.contributor.author | Blanchet, P | |
dc.contributor.author | Brureau, L | |
dc.contributor.author | Kaneva, R | |
dc.contributor.author | Slavov, C | |
dc.contributor.author | Mitev, V | |
dc.contributor.author | Leach, RJ | |
dc.contributor.author | Weaver, B | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Cuk, K | |
dc.contributor.author | Fujita, M | |
dc.contributor.author | Holleczek, B | |
dc.contributor.author | Saum, K-U | |
dc.contributor.author | Klein, EA | |
dc.contributor.author | Hsing, AW | |
dc.contributor.author | Kittles, RA | |
dc.contributor.author | Murphy, AB | |
dc.contributor.author | Logothetis, CJ | |
dc.contributor.author | Kim, J | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Steele, L | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Ding, YC | |
dc.contributor.author | Isaacs, WB | |
dc.contributor.author | Nemesure, B | |
dc.contributor.author | Hennis, AJM | |
dc.contributor.author | Carpten, J | |
dc.contributor.author | Pandha, H | |
dc.contributor.author | Michael, A | |
dc.contributor.author | De Ruyck, K | |
dc.contributor.author | De Meerleer, G | |
dc.contributor.author | Ost, P | |
dc.contributor.author | Lophatananon, A | |
dc.contributor.author | Xu, J | |
dc.contributor.author | Razack, A | |
dc.contributor.author | Lim, J | |
dc.contributor.author | Teo, S-H | |
dc.contributor.author | Newcomb, LF | |
dc.contributor.author | Lin, DW | |
dc.contributor.author | Fowke, JH | |
dc.contributor.author | Neslund-Dudas, C | |
dc.contributor.author | Rybicki, BA | |
dc.contributor.author | Gamulin, M | |
dc.contributor.author | Wan, P | |
dc.contributor.author | Lessel, D | |
dc.contributor.author | Kulis, T | |
dc.contributor.author | Usmani, N | |
dc.contributor.author | Singhal, S | |
dc.contributor.author | Parliament, M | |
dc.contributor.author | Claessens, F | |
dc.contributor.author | Joniau, S | |
dc.contributor.author | Van den Broeck, T | |
dc.contributor.author | Gago-Dominguez, M | |
dc.contributor.author | Castelao, JE | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Martinez, ME | |
dc.contributor.author | Larkin, S | |
dc.contributor.author | Townsend, PA | |
dc.contributor.author | Aukim-Hastie, C | |
dc.contributor.author | Bush, WS | |
dc.contributor.author | Aldrich, MC | |
dc.contributor.author | Crawford, DC | |
dc.contributor.author | Srivastava, S | |
dc.contributor.author | Cullen, JC | |
dc.contributor.author | Petrovics, G | |
dc.contributor.author | Wilkens, LR | |
dc.contributor.author | Casey, G | |
dc.contributor.author | Roobol, MJ | |
dc.contributor.author | Jenster, G | |
dc.contributor.author | van Schaik, RHN | |
dc.contributor.author | Hu, JJ | |
dc.contributor.author | Sanderson, M | |
dc.contributor.author | Varma, R | |
dc.contributor.author | McKean-Cowdin, R | |
dc.contributor.author | Torres, M | |
dc.contributor.author | Mancuso, N | |
dc.contributor.author | Stevens, VL | |
dc.contributor.author | Berndt, SI | |
dc.contributor.author | Van Den Eeden, SK | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Cook, MB | |
dc.contributor.author | Wiklund, F | |
dc.contributor.author | Nakagawa, H | |
dc.contributor.author | Witte, JS | |
dc.contributor.author | Eeles, RA | |
dc.contributor.author | Kote-Jarai, Z | |
dc.contributor.author | Gapstur, SM | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Carter, BD | |
dc.contributor.author | Schleutker, J | |
dc.contributor.author | Tammela, TLJ | |
dc.contributor.author | Sipeky, C | |
dc.contributor.author | Auvinen, A | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | MacInnis, RJ | |
dc.contributor.author | Cybulski, C | |
dc.contributor.author | Wokołorczyk, D | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Neal, DE | |
dc.contributor.author | Donovan, JL | |
dc.contributor.author | Hamdy, FC | |
dc.contributor.author | Martin, RM | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | Nielsen, SF | |
dc.contributor.author | Weischer, M | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Røder, MA | |
dc.contributor.author | Iversen, P | |
dc.contributor.author | Batra, J | |
dc.contributor.author |
Chambers, S |
|
dc.contributor.author | Moya, L | |
dc.contributor.author | Horvath, L | |
dc.contributor.author | Clements, JA | |
dc.contributor.author | Tilley, W | |
dc.contributor.author | Risbridger, GP | |
dc.contributor.author | Gronberg, H | |
dc.contributor.author | Aly, M | |
dc.contributor.author | Szulkin, R | |
dc.contributor.author | Eklund, M | |
dc.contributor.author | Nordström, T | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Ghoussaini, M | |
dc.contributor.author | Travis, RC | |
dc.contributor.author | Key, TJ | |
dc.contributor.author | Riboli, E | |
dc.contributor.author | Park, JY | |
dc.contributor.author | Sellers, TA | |
dc.contributor.author | Lin, H-Y | |
dc.contributor.author | Albanes, D | |
dc.contributor.author | Weinstein, SJ | |
dc.contributor.author | Mucci, LA | |
dc.contributor.author | Giovannucci, E | |
dc.contributor.author | Lindstrom, S | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | Penney, KL | |
dc.contributor.author | Turman, C | |
dc.contributor.author | Tangen, CM | |
dc.contributor.author | Goodman, PJ | |
dc.contributor.author | Thompson, IM | |
dc.contributor.author | Hamilton, RJ | |
dc.contributor.author | Fleshner, NE | |
dc.contributor.author | Finelli, A | |
dc.contributor.author | Parent, M-É | |
dc.contributor.author | Stanford, JL | |
dc.contributor.author | Ostrander, EA | |
dc.contributor.author | Geybels, MS | |
dc.contributor.author | Koutros, S | |
dc.contributor.author | Freeman, LEB | |
dc.contributor.author | Stampfer, M | |
dc.contributor.author | Wolk, A | |
dc.contributor.author | Håkansson, N | |
dc.contributor.author | Andriole, GL | |
dc.contributor.author | Hoover, RN | |
dc.contributor.author | Machiela, MJ | |
dc.contributor.author | Sørensen, KD | |
dc.contributor.author | Borre, M | |
dc.contributor.author | Blot, WJ | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Yeboah, ED | |
dc.contributor.author | Mensah, JE | |
dc.contributor.author | Lu, Y-J | |
dc.date.accessioned | 2021-11-18T03:00:24Z | |
dc.date.available | 2020-11-05 | |
dc.date.available | 2021-11-18T03:00:24Z | |
dc.date.issued | 2021-01-04 | |
dc.identifier.citation | Nature Genetics, 2021, 53, (1), pp. 65-75 | |
dc.identifier.issn | 1061-4036 | |
dc.identifier.issn | 1546-1718 | |
dc.identifier.uri | http://hdl.handle.net/10453/151698 | |
dc.description.abstract | Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Nature Research | |
dc.relation.ispartof | Nature Genetics | |
dc.relation.isbasedon | 10.1038/s41588-020-00748-0 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 06 Biological Sciences, 11 Medical and Health Sciences | |
dc.subject.classification | Developmental Biology | |
dc.subject.mesh | Continental Population Groups | |
dc.subject.mesh | Genetic Loci | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Genome-Wide Association Study | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Molecular Sequence Annotation | |
dc.subject.mesh | Neoplasm Invasiveness | |
dc.subject.mesh | Odds Ratio | |
dc.subject.mesh | Prostatic Neoplasms | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Prostatic Neoplasms | |
dc.subject.mesh | Neoplasm Invasiveness | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Odds Ratio | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Continental Population Groups | |
dc.subject.mesh | Male | |
dc.subject.mesh | Genome-Wide Association Study | |
dc.subject.mesh | Genetic Loci | |
dc.subject.mesh | Molecular Sequence Annotation | |
dc.subject.mesh | Continental Population Groups | |
dc.subject.mesh | Genetic Loci | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Genome-Wide Association Study | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Molecular Sequence Annotation | |
dc.subject.mesh | Neoplasm Invasiveness | |
dc.subject.mesh | Odds Ratio | |
dc.subject.mesh | Prostatic Neoplasms | |
dc.subject.mesh | Risk Factors | |
dc.title | Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. | |
dc.type | Journal Article | |
utslib.citation.volume | 53 | |
utslib.location.activity | United States | |
utslib.for | 06 Biological Sciences | |
utslib.for | 11 Medical and Health Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
utslib.copyright.status | closed_access | * |
pubs.consider-herdc | false | |
dc.date.updated | 2021-11-18T03:00:15Z | |
pubs.issue | 1 | |
pubs.publication-status | Published | |
pubs.volume | 53 | |
utslib.citation.issue | 1 |
Abstract:
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph