Manipulation of the Upper Respiratory Microbiota to Reduce Incidence and Severity of Upper Respiratory Viral Infections: A Literature Review.

Nesbitt, H; Burke, C; Haghi, M

Manipulation of the Upper Respiratory Microbiota to Reduce Incidence and Severity of Upper Respiratory Viral Infections: A Literature Review.

Nesbitt, H Burke, C

Haghi, M

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Publisher:: Frontiers Media SA
Publication Type:: Journal Article
Citation:: Frontiers in microbiology, 2021, 12, pp. 713703
Issue Date:: 2021-01

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Field	Value	Language
dc.contributor.author	Nesbitt, H
dc.contributor.author	Burke, C https://orcid.org/0000-0002-8917-0019
dc.contributor.author	Haghi, M https://orcid.org/0000-0002-3362-1845
dc.date.accessioned	2021-11-18T22:46:45Z
dc.date.available	2021-08-06
dc.date.available	2021-11-18T22:46:45Z
dc.date.issued	2021-01
dc.identifier.citation	Frontiers in microbiology, 2021, 12, pp. 713703
dc.identifier.issn	1664-302X
dc.identifier.issn	1664-302X
dc.identifier.uri	http://hdl.handle.net/10453/151721
dc.description.abstract	There is a high incidence of upper respiratory viral infections in the human population, with infection severity being unique to each individual. Upper respiratory viruses have been associated previously with secondary bacterial infection, however, several cross-sectional studies analyzed in the literature indicate that an inverse relationship can also occur. Pathobiont abundance and/or bacterial dysbiosis can impair epithelial integrity and predispose an individual to viral infection. In this review we describe common commensal microorganisms that have the capacity to reduce the abundance of pathobionts and maintain bacterial symbiosis in the upper respiratory tract and discuss the potential and limitations of localized probiotic formulations of commensal bacteria to reduce the incidence and severity of viral infections.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Frontiers Media SA
dc.relation.ispartof	Frontiers in microbiology
dc.relation.isbasedon	10.3389/fmicb.2021.713703
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0502 Environmental Science and Management, 0503 Soil Sciences, 0605 Microbiology
dc.title	Manipulation of the Upper Respiratory Microbiota to Reduce Incidence and Severity of Upper Respiratory Viral Infections: A Literature Review.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	Switzerland
utslib.for	0502 Environmental Science and Management
utslib.for	0503 Soil Sciences
utslib.for	0605 Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2021-11-18T22:46:44Z
pubs.publication-status	Published
pubs.volume	12

Abstract:

There is a high incidence of upper respiratory viral infections in the human population, with infection severity being unique to each individual. Upper respiratory viruses have been associated previously with secondary bacterial infection, however, several cross-sectional studies analyzed in the literature indicate that an inverse relationship can also occur. Pathobiont abundance and/or bacterial dysbiosis can impair epithelial integrity and predispose an individual to viral infection. In this review we describe common commensal microorganisms that have the capacity to reduce the abundance of pathobionts and maintain bacterial symbiosis in the upper respiratory tract and discuss the potential and limitations of localized probiotic formulations of commensal bacteria to reduce the incidence and severity of viral infections.

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http://hdl.handle.net/10453/151721