Does disrupting the orbitofrontal cortex alter sensitivity to punishment? A potential mechanism of compulsivity.

Turner, KM; Balleine, BW; Bradfield, LA

Does disrupting the orbitofrontal cortex alter sensitivity to punishment? A potential mechanism of compulsivity.

Turner, KM Balleine, BW Bradfield, LA

Permalink

Publisher:: AMER PSYCHOLOGICAL ASSOC
Publication Type:: Journal Article
Citation:: Behavioral neuroscience, 2021, 135, (2), pp. 174-181
Issue Date:: 2021-04

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

The embargo period expires on 1 Apr 2022

Adobe PDF

Download Accepted versionAdobe PDF (335.13 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Turner, KM
dc.contributor.author	Balleine, BW
dc.contributor.author	Bradfield, LA
dc.date.accessioned	2021-12-01T02:10:42Z
dc.date.available	2021-12-01T02:10:42Z
dc.date.issued	2021-04
dc.identifier.citation	Behavioral neuroscience, 2021, 135, (2), pp. 174-181
dc.identifier.issn	0735-7044
dc.identifier.issn	1939-0084
dc.identifier.uri	http://hdl.handle.net/10453/151955
dc.description.abstract	Abnormal orbitofrontal cortex (OFC) activity is one of the most common findings from neuroimaging studies of individuals with compulsive disorders such as substance use disorder and obsessive-compulsive disorder. The nature of this abnormality is complex, however, with some studies reporting the OFC to be over-active in compulsive individuals relative to controls, whereas other studies report it being under-active, and a further set of studies reporting OFC abnormality in both directions within the same individuals. The OFC has been implicated in a broad range of cognitive processes such as decision-making and goal-directed action. OFC dysfunction could thus impair decision-making and goal-directed action, leading to the kinds of cognitive/behavioral deficits observed in individuals with compulsive disorders. One such deficit that could arise as a result of OFC dysfunction is an altered sensitivity to punishment, which is one of the core characteristics displayed by individuals across multiple types of compulsive disorders. It is, therefore, the aim of the current review to assess the evidence implicating the OFC in adaptation to punishment and to attempt to identify the critical factors that determine this relationship. We distill from this analysis some guidelines for future studies attempting to determine the precise role of the OFC in punishment. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
dc.format	Print
dc.language	eng
dc.publisher	AMER PSYCHOLOGICAL ASSOC
dc.relation.ispartof	Behavioral neuroscience
dc.relation.isbasedon	10.1037/bne0000443
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences
dc.subject.classification	Behavioral Science & Comparative Psychology
dc.subject.mesh	Prefrontal Cortex
dc.subject.mesh	Humans
dc.subject.mesh	Motivation
dc.subject.mesh	Punishment
dc.subject.mesh	Obsessive-Compulsive Disorder
dc.subject.mesh	Humans
dc.subject.mesh	Motivation
dc.subject.mesh	Obsessive-Compulsive Disorder
dc.subject.mesh	Prefrontal Cortex
dc.subject.mesh	Punishment
dc.title	Does disrupting the orbitofrontal cortex alter sensitivity to punishment? A potential mechanism of compulsivity.
dc.type	Journal Article
utslib.citation.volume	135
utslib.location.activity	United States
utslib.for	1109 Neurosciences
utslib.for	1701 Psychology
utslib.for	1702 Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2022-04-01T00:00:00+1000Z
dc.date.updated	2021-12-01T02:10:41Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	135
utslib.citation.issue	2

Abstract:

Abnormal orbitofrontal cortex (OFC) activity is one of the most common findings from neuroimaging studies of individuals with compulsive disorders such as substance use disorder and obsessive-compulsive disorder. The nature of this abnormality is complex, however, with some studies reporting the OFC to be over-active in compulsive individuals relative to controls, whereas other studies report it being under-active, and a further set of studies reporting OFC abnormality in both directions within the same individuals. The OFC has been implicated in a broad range of cognitive processes such as decision-making and goal-directed action. OFC dysfunction could thus impair decision-making and goal-directed action, leading to the kinds of cognitive/behavioral deficits observed in individuals with compulsive disorders. One such deficit that could arise as a result of OFC dysfunction is an altered sensitivity to punishment, which is one of the core characteristics displayed by individuals across multiple types of compulsive disorders. It is, therefore, the aim of the current review to assess the evidence implicating the OFC in adaptation to punishment and to attempt to identify the critical factors that determine this relationship. We distill from this analysis some guidelines for future studies attempting to determine the precise role of the OFC in punishment. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/151955