Cervicovaginal microbiota and women's health outcomes

Bryant, CJ; Burke, C; Huston, WM

Cervicovaginal microbiota and women's health outcomes

Bryant, CJ Burke, C

Huston, WM

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Publisher:: CSIRO Publishing
Publication Type:: Journal Article
Citation:: Microbiology Australia, 2021, 42, (2), pp. 65-68
Issue Date:: 2021-06-01

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Field	Value	Language
dc.contributor.author	Bryant, CJ
dc.contributor.author	Burke, C https://orcid.org/0000-0002-8917-0019
dc.contributor.author	Huston, WM
dc.date.accessioned	2021-12-13T23:21:57Z
dc.date.available	2021-12-13T23:21:57Z
dc.date.issued	2021-06-01
dc.identifier.citation	Microbiology Australia, 2021, 42, (2), pp. 65-68
dc.identifier.issn	1324-4272
dc.identifier.issn	2201-9189
dc.identifier.uri	http://hdl.handle.net/10453/152296
dc.description.abstract	The human cervicovaginal microbiome has an important role in the health and homoeostasis of the female reproductive tract. A eubiotic microbiome is typically dominated with lactic acid producing bacteria and is categorised into five community state types. Issues arise when the microbiome becomes dysbiotic, with the microbial composition shifting to contain a greater relative abundance of strict and facultative anaerobes. This shift will lead to several adverse changes in the vaginal environment including compromised epithelial cells, cell death, inflammation, and greater susceptibility to infection. These changes are associated with various adverse outcomes including infections, preterm birth, and infertility. In this review, we discuss how the cervicovaginal microbiome influences these outcomes and possible future directions of treatment and research.
dc.language	en
dc.publisher	CSIRO Publishing
dc.relation.ispartof	Microbiology Australia
dc.relation.isbasedon	10.1071/MA21022
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	0601 Biochemistry and Cell Biology, 0605 Microbiology
dc.title	Cervicovaginal microbiota and women's health outcomes
dc.type	Journal Article
utslib.citation.volume	42
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	0605 Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	recently_added	*
dc.date.updated	2021-12-13T23:21:53Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	42
utslib.citation.issue	2

Abstract:

The human cervicovaginal microbiome has an important role in the health and homoeostasis of the female reproductive tract. A eubiotic microbiome is typically dominated with lactic acid producing bacteria and is categorised into five community state types. Issues arise when the microbiome becomes dysbiotic, with the microbial composition shifting to contain a greater relative abundance of strict and facultative anaerobes. This shift will lead to several adverse changes in the vaginal environment including compromised epithelial cells, cell death, inflammation, and greater susceptibility to infection. These changes are associated with various adverse outcomes including infections, preterm birth, and infertility. In this review, we discuss how the cervicovaginal microbiome influences these outcomes and possible future directions of treatment and research.

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http://hdl.handle.net/10453/152296