Progressing our understanding of the impacts of nutrition on the brain and behaviour in anorexia nervosa: a tyrosine case study example

Hart, M; Sibbritt, D; Williams, LT; Nunn, KP; Wilcken, B

Progressing our understanding of the impacts of nutrition on the brain and behaviour in anorexia nervosa: a tyrosine case study example

Hart, M Sibbritt, D

Williams, LT Nunn, KP Wilcken, B

Permalink

Publisher:: BMC
Publication Type:: Journal Article
Citation:: Journal of Eating Disorders, 2021, 9, (1), pp. 86
Issue Date:: 2021-07-13

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download full textAdobe PDF (576.57 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Hart, M
dc.contributor.author	Sibbritt, D https://orcid.org/0000-0003-3561-9447
dc.contributor.author	Williams, LT
dc.contributor.author	Nunn, KP
dc.contributor.author	Wilcken, B
dc.date.accessioned	2021-12-14T02:46:49Z
dc.date.available	2021-06-28
dc.date.available	2021-12-14T02:46:49Z
dc.date.issued	2021-07-13
dc.identifier.citation	Journal of Eating Disorders, 2021, 9, (1), pp. 86
dc.identifier.issn	2050-2974
dc.identifier.issn	2050-2974
dc.identifier.uri	http://hdl.handle.net/10453/152301
dc.description.abstract	Anorexia nervosa is a severe and complex illness associated with a lack of efficacious treatment. The effects of nutrition on the brain and behaviour is of particular interest, though an area of limited research. Tyrosine, a non-essential amino acid, is a precursor to the catecholamines dopamine, noradrenaline and adrenaline. Ongoing tyrosine administration has been proposed as an adjunct treatment through increasing blood tyrosine sufficiently to facilitate brain catecholamine synthesis. The effects of tyrosine supplementation in adolescents with anorexia nervosa remain to be tested. This study had approval from the Hunter New England Human Research Ethics Committee (06/05/24/3.06). We aimed to explore the pharmacokinetics of tyrosine loading in adolescents with anorexia nervosa (n = 2) and healthy peers (n = 2). The first stage of the study explored the pharmacological response to a single, oral tyrosine load in adolescents (aged 12-15 years) with anorexia nervosa and healthy peers. Participants with anorexia nervosa then continued tyrosine twice daily for 12 weeks. There were no measured side effects. Peak tyrosine levels occurred at approximately two to three hours and approached baseline levels by eight hours. Variation in blood tyrosine response was observed and warrants further exploration, along with potential effects of continued tyrosine administration in anorexia nervosa.
dc.format	Electronic
dc.language	eng
dc.publisher	BMC
dc.relation.ispartof	Journal of Eating Disorders
dc.relation.isbasedon	10.1186/s40337-021-00439-z
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1111 Nutrition and Dietetics, 1701 Psychology
dc.title	Progressing our understanding of the impacts of nutrition on the brain and behaviour in anorexia nervosa: a tyrosine case study example
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	England
utslib.for	1111 Nutrition and Dietetics
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	open_access	*
dc.date.updated	2021-12-14T02:46:46Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	9
utslib.citation.issue	1

Abstract:

Anorexia nervosa is a severe and complex illness associated with a lack of efficacious treatment. The effects of nutrition on the brain and behaviour is of particular interest, though an area of limited research. Tyrosine, a non-essential amino acid, is a precursor to the catecholamines dopamine, noradrenaline and adrenaline. Ongoing tyrosine administration has been proposed as an adjunct treatment through increasing blood tyrosine sufficiently to facilitate brain catecholamine synthesis. The effects of tyrosine supplementation in adolescents with anorexia nervosa remain to be tested. This study had approval from the Hunter New England Human Research Ethics Committee (06/05/24/3.06). We aimed to explore the pharmacokinetics of tyrosine loading in adolescents with anorexia nervosa (n = 2) and healthy peers (n = 2). The first stage of the study explored the pharmacological response to a single, oral tyrosine load in adolescents (aged 12-15 years) with anorexia nervosa and healthy peers. Participants with anorexia nervosa then continued tyrosine twice daily for 12 weeks. There were no measured side effects. Peak tyrosine levels occurred at approximately two to three hours and approached baseline levels by eight hours. Variation in blood tyrosine response was observed and warrants further exploration, along with potential effects of continued tyrosine administration in anorexia nervosa.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/152301