Overcoming hydrolytic degradation challenges in topical delivery: Non-aqueous nano-emulsions.

Kadukkattil Ramanunny, A; Singh, SK; Wadhwa, S; Gulati, M; Kapoor, B; Khursheed, R; Kuppusamy, G; Dua, K; Dureja, H; Chellappan, DK; Jha, NK; Gupta, PK; Vishwas, S

Overcoming hydrolytic degradation challenges in topical delivery: Non-aqueous nano-emulsions.

Kadukkattil Ramanunny, A Singh, SK Wadhwa, S Gulati, M Kapoor, B Khursheed, R Kuppusamy, G Dua, K

Dureja, H Chellappan, DK Jha, NK Gupta, PK Vishwas, S

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Publisher:: Informa UK Limited
Publication Type:: Journal Article
Citation:: Expert opinion on drug delivery, 2021
Issue Date:: 2021-12-16

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Field	Value	Language
dc.contributor.author	Kadukkattil Ramanunny, A
dc.contributor.author	Singh, SK
dc.contributor.author	Wadhwa, S
dc.contributor.author	Gulati, M
dc.contributor.author	Kapoor, B
dc.contributor.author	Khursheed, R
dc.contributor.author	Kuppusamy, G
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Dureja, H
dc.contributor.author	Chellappan, DK
dc.contributor.author	Jha, NK
dc.contributor.author	Gupta, PK
dc.contributor.author	Vishwas, S
dc.date.accessioned	2021-12-28T05:36:21Z
dc.date.available	2021-12-28T05:36:21Z
dc.date.issued	2021-12-16
dc.identifier.citation	Expert opinion on drug delivery, 2021
dc.identifier.issn	1742-5247
dc.identifier.issn	1744-7593
dc.identifier.uri	http://hdl.handle.net/10453/152549
dc.description.abstract	<h4>Introduction</h4>Non-aqueous nano-emulsions (NANEs) are colloidal lipid-based dispersions with nano-sized droplets formed by mixing two immiscible phases, none of which happens to be an aqueous phase. Their ability to incorporate water and oxygen sensitive drugs without any susceptibility to degradation makes them the optimum dosage form for such candidates. In NANEs, polar liquids or polyols replace the aqueous phase while surfactants remain same as used in conventional emulsions. They are a part of the nano-emulsion family albeit with substantial difference in composition and application.<h4>Areas covered</h4>The present review provides a brief insight into the strategies of loading water-sensitive drugs into NANEs. Further advancement in these anhydrous systems with the use of solid particulate surfactants in the form of Pickering emulsions is also discussed.<h4>Expert opinion</h4>NANEs offer a unique platform for delivering water-sensitive drugs by loading them in anhydrous formulation. The biggest advantage of NANEs vis-à-vis the other nano-cargos is that they can also be prepared without using equipment-intensive techniques. However, the use of NANEs in drug delivery is quite limited. Looking at the small number of studies available in this direction, a need for further research in this field is required to explore this delivery system further.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Informa UK Limited
dc.relation.ispartof	Expert opinion on drug delivery
dc.relation.isbasedon	10.1080/17425247.2022.2019218
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.title	Overcoming hydrolytic degradation challenges in topical delivery: Non-aqueous nano-emulsions.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2021-12-28T05:36:16Z
pubs.publication-status	Published

Abstract:

Introduction

Non-aqueous nano-emulsions (NANEs) are colloidal lipid-based dispersions with nano-sized droplets formed by mixing two immiscible phases, none of which happens to be an aqueous phase. Their ability to incorporate water and oxygen sensitive drugs without any susceptibility to degradation makes them the optimum dosage form for such candidates. In NANEs, polar liquids or polyols replace the aqueous phase while surfactants remain same as used in conventional emulsions. They are a part of the nano-emulsion family albeit with substantial difference in composition and application.

Areas covered

The present review provides a brief insight into the strategies of loading water-sensitive drugs into NANEs. Further advancement in these anhydrous systems with the use of solid particulate surfactants in the form of Pickering emulsions is also discussed.

Expert opinion

NANEs offer a unique platform for delivering water-sensitive drugs by loading them in anhydrous formulation. The biggest advantage of NANEs vis-à-vis the other nano-cargos is that they can also be prepared without using equipment-intensive techniques. However, the use of NANEs in drug delivery is quite limited. Looking at the small number of studies available in this direction, a need for further research in this field is required to explore this delivery system further.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/152549