Jewish cultural and religious factors and uptake of population-based BRCA testing across denominations: a cohort study.
Reisel, D
Burnell, M
Side, L
Loggenberg, K
Gessler, S
Desai, R
Sanderson, S
Brady, AF
Dorkins, H
Wallis, Y
Jacobs, C
Legood, R
Beller, U
Tomlinson, I
Wardle, J
Menon, U
Jacobs, I
Manchanda, R
Legood, R
Beller, U
Tomlinson, I
Wardle, J
Menon, U
Jacobs, I
Manchanda, R
- Publisher:
- Wiley
- Publication Type:
- Journal Article
- Citation:
- BJOG : an international journal of obstetrics and gynaecology, 2021
- Issue Date:
- 2021-11-10
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|---|---|---|---|---|---|
| BJOG - 2021 - Reisel - Jewish cultural and religious factors and uptake of population%E2%80%90based BRCA testing across.pdf | Published Version | 641.44 kB |
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Objective
To evaluate the association of Jewish cultural and religious identity and denominational affiliation with interest in, intention to undertake and uptake of population-based BRCA (Breast Cancer Gene)-testing.Design
Cohort-study set within recruitment to GCaPPS-trial (ISRCTN73338115).Setting
London Ashkenazi-Jewish (AJ) population.Population or sample
AJ men and women, >18 years.Methods
Participants were self-referred, and attended recruitment clinics (clusters) for pre-test counselling. Subsequently consenting individuals underwent BRCA testing. Participants self-identified to one Jewish denomination: Conservative/Liberal/Reform/Traditional/Orthodox/Unaffiliated. Validated scales measured Jewish Cultural-Identity (JI) and Jewish Religious-identity (JR). Four-item Likert-scales analysed initial 'interest' and 'intention to test' pre-counselling. Item-Response-Theory and graded-response models, modelled responses to JI and JR scales. Ordered/multinomial logistic regression modelling evaluated association of JI-scale, JR-scale and Jewish Denominational affiliation on interest, intention and uptake of BRCA testing.Main outcome measures
Interest, intention, uptake of BRCA testing.Results
In all, 935 AJ women/men of mean age = 53.8 (S.D = 15.02) years, received pre-test education and counselling through 256 recruitment clinic clusters (median cluster size = 3). Denominational affiliations included Conservative/Masorti = 91 (10.2%); Liberal = 82 (9.2%), Reform = 135 (15.1%), Traditional = 212 (23.7%), Orthodox = 239 (26.7%); and Unaffiliated/Non-practising = 135 (15.1%). Overall BRCA testing uptake was 88%. Pre-counselling, 96% expressed interest and 60% intention to test. JI and JR scores were highest for Orthodox, followed by Conservative/Masorti, Traditional, Reform, Liberal and Unaffiliated Jewish denominations. Regression modelling showed no significant association between overall Jewish Cultural or Religious Identity with either interest, intention or uptake of BRCA testing. Interest, intention and uptake of BRCA testing was not significantly associated with denominational affiliation.Conclusions
Jewish religious/cultural identity and denominational affiliation do not appear to influence interest, intention or uptake of population-based BRCA testing. BRCA testing was robust across all Jewish denominations.Tweetable abstract
Jewish cultural/religious factors do not affect BRCA testing, with robust uptake seen across all denominational affiliations.Please use this identifier to cite or link to this item: