Functional swallowing outcomes related to radiation exposure to dysphagia and aspiration-related structures in patients with head and neck cancer undergoing definitive and postoperative intensity-modulated radiotherapy.

Charters, E; Bogaardt, H; Clark, J; Milross, C; Freeman-Sanderson, A; Ballard, K; Britton, R; McCabe, N; Davis, H; Sullivan, T; Wu, R

Functional swallowing outcomes related to radiation exposure to dysphagia and aspiration-related structures in patients with head and neck cancer undergoing definitive and postoperative intensity-modulated radiotherapy.

Charters, E Bogaardt, H Clark, J Milross, C Freeman-Sanderson, A

Ballard, K Britton, R McCabe, N Davis, H Sullivan, T Wu, R

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Head Neck, 2022, 44, (2), pp. 399-411
Issue Date:: 2022-02

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Field	Value	Language
dc.contributor.author	Charters, E
dc.contributor.author	Bogaardt, H
dc.contributor.author	Clark, J
dc.contributor.author	Milross, C
dc.contributor.author	Freeman-Sanderson, A https://orcid.org/0000-0003-2161-6421
dc.contributor.author	Ballard, K
dc.contributor.author	Britton, R
dc.contributor.author	McCabe, N
dc.contributor.author	Davis, H
dc.contributor.author	Sullivan, T
dc.contributor.author	Wu, R
dc.date.accessioned	2022-01-28T02:11:19Z
dc.date.available	2021-11-08
dc.date.available	2022-01-28T02:11:19Z
dc.date.issued	2022-02
dc.identifier.citation	Head Neck, 2022, 44, (2), pp. 399-411
dc.identifier.issn	1043-3074
dc.identifier.issn	1097-0347
dc.identifier.uri	http://hdl.handle.net/10453/153725
dc.description.abstract	BACKGROUND: The relationship between swallowing outcomes and radiotherapy dose to dysphagia and aspiration-related structures (DARS) may be different following definitive versus postoperative radiotherapy (PORT) for mucosal head and neck cancer (HNC) and has not been well-studied. METHOD: Patient- and clinician-reported swallowing measures were prospectively collected at six time points from baseline to 24 months postradiotherapy HNC. Radiotherapy plans were retrospectively analyzed to assess dose delivered to DARS. The association between swallowing outcomes and participant demographics, tumor characteristics, and radiotherapy dose in definitive and postoperative treatment cohorts was assessed. RESULTS: Ninety-three participants who received radiotherapy for HNC were included in the analysis (n = 49 definitive radiotherapy for laryngeal/pharyngeal primary tumors and n = 44 postoperative PORT for predominantly oral cavity/salivary gland tumors). Participants undergoing PORT had lower doses to DARS than those undergoing definitive RT. High dose to the pharyngeal constrictors and base of tongue for definitive RT and the esophageal inlet, supraglottic larynx and cervical esophagus for the PORT group were associated with worse swallowing function. CONCLUSION: Radiation dose to DARS is associated with post-treatment swallowing outcomes. These dose/outcome relationships may vary between the definitive and postoperative settings.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Head Neck
dc.relation.isbasedon	10.1002/hed.26936
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1105 Dentistry
dc.subject.classification	Otorhinolaryngology
dc.title	Functional swallowing outcomes related to radiation exposure to dysphagia and aspiration-related structures in patients with head and neck cancer undergoing definitive and postoperative intensity-modulated radiotherapy.
dc.type	Journal Article
utslib.citation.volume	44
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1105 Dentistry
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Speech Pathology
utslib.copyright.status	closed_access	*
dc.date.updated	2022-01-28T02:11:18Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	44
utslib.citation.issue	2

Abstract:

BACKGROUND: The relationship between swallowing outcomes and radiotherapy dose to dysphagia and aspiration-related structures (DARS) may be different following definitive versus postoperative radiotherapy (PORT) for mucosal head and neck cancer (HNC) and has not been well-studied. METHOD: Patient- and clinician-reported swallowing measures were prospectively collected at six time points from baseline to 24 months postradiotherapy HNC. Radiotherapy plans were retrospectively analyzed to assess dose delivered to DARS. The association between swallowing outcomes and participant demographics, tumor characteristics, and radiotherapy dose in definitive and postoperative treatment cohorts was assessed. RESULTS: Ninety-three participants who received radiotherapy for HNC were included in the analysis (n = 49 definitive radiotherapy for laryngeal/pharyngeal primary tumors and n = 44 postoperative PORT for predominantly oral cavity/salivary gland tumors). Participants undergoing PORT had lower doses to DARS than those undergoing definitive RT. High dose to the pharyngeal constrictors and base of tongue for definitive RT and the esophageal inlet, supraglottic larynx and cervical esophagus for the PORT group were associated with worse swallowing function. CONCLUSION: Radiation dose to DARS is associated with post-treatment swallowing outcomes. These dose/outcome relationships may vary between the definitive and postoperative settings.

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http://hdl.handle.net/10453/153725