Generation and analysis of 3D cell culture models for drug discovery.

Belfiore, L; Aghaei, B; Law, AMK; Dobrowolski, JC; Raftery, LJ; Tjandra, AD; Yee, C; Piloni, A; Volkerling, A; Ferris, CJ; Engel, M

Generation and analysis of 3D cell culture models for drug discovery.

Belfiore, L Aghaei, B Law, AMK Dobrowolski, JC Raftery, LJ Tjandra, AD Yee, C

Piloni, A Volkerling, A Ferris, CJ Engel, M

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Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: Eur J Pharm Sci, 2021, 163, pp. 105876
Issue Date:: 2021-08-01

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Field	Value	Language
dc.contributor.author	Belfiore, L
dc.contributor.author	Aghaei, B
dc.contributor.author	Law, AMK
dc.contributor.author	Dobrowolski, JC
dc.contributor.author	Raftery, LJ
dc.contributor.author	Tjandra, AD
dc.contributor.author	Yee, C https://orcid.org/0000-0001-7243-5634
dc.contributor.author	Piloni, A
dc.contributor.author	Volkerling, A
dc.contributor.author	Ferris, CJ
dc.contributor.author	Engel, M
dc.date.accessioned	2022-02-02T20:56:40Z
dc.date.available	2021-05-04
dc.date.available	2022-02-02T20:56:40Z
dc.date.issued	2021-08-01
dc.identifier.citation	Eur J Pharm Sci, 2021, 163, pp. 105876
dc.identifier.issn	0928-0987
dc.identifier.issn	1879-0720
dc.identifier.uri	http://hdl.handle.net/10453/154146
dc.description.abstract	Successful preclinical drug testing relies in part on data generated using in vitro cell culture models that recapitulate the structure and function of tumours and other tissues in vivo. The growing evidence that 3D cell models can more accurately predict the efficacy of drug responses compared to traditionally utilised 2D cell culture systems has led to continuous scientific and technological advances that enable better physiologically representative in vitro modelling of in vivo tissues. This review will provide an overview of the utility of current 3D cell models from a drug screening perspective and explore the future of 3D cell models for drug discovery applications.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER
dc.relation.ispartof	Eur J Pharm Sci
dc.relation.isbasedon	10.1016/j.ejps.2021.105876
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.subject.mesh	Cell Culture Techniques
dc.subject.mesh	Drug Discovery
dc.subject.mesh	Drug Evaluation, Preclinical
dc.subject.mesh	Cell Culture Techniques
dc.subject.mesh	Drug Evaluation, Preclinical
dc.subject.mesh	Drug Discovery
dc.title	Generation and analysis of 3D cell culture models for drug discovery.
dc.type	Journal Article
utslib.citation.volume	163
utslib.location.activity	Netherlands
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-02-02T20:56:37Z
pubs.publication-status	Published
pubs.volume	163

Abstract:

Successful preclinical drug testing relies in part on data generated using in vitro cell culture models that recapitulate the structure and function of tumours and other tissues in vivo. The growing evidence that 3D cell models can more accurately predict the efficacy of drug responses compared to traditionally utilised 2D cell culture systems has led to continuous scientific and technological advances that enable better physiologically representative in vitro modelling of in vivo tissues. This review will provide an overview of the utility of current 3D cell models from a drug screening perspective and explore the future of 3D cell models for drug discovery applications.

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http://hdl.handle.net/10453/154146