Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review

Jha, NK; Chen, W-C; Kumar, S; Dubey, R; Tsai, L-W; Kar, R; Jha, SK; Gupta, PK; Sharma, A; Gundamaraju, R; Pant, K; Mani, S; Singh, SK; Maccioni, RB; Datta, T; Singh, SK; Gupta, G; Prasher, P; Dua, K; Dey, A; Sharma, C; Mughal, YH; Ruokolainen, J; Kesari, KK; Ojha, S

Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review

Jha, NK Chen, W-C Kumar, S Dubey, R Tsai, L-W Kar, R Jha, SK Gupta, PK Sharma, A Gundamaraju, R Pant, K Mani, S Singh, SK Maccioni, RB Datta, T Singh, SK Gupta, G Prasher, P Dua, K

Dey, A Sharma, C Mughal, YH Ruokolainen, J Kesari, KK Ojha, S

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Publisher:: The Royal Society
Publication Type:: Journal Article
Citation:: Open Biology, 2022, 12, (3)
Issue Date:: 2022-03

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Field	Value	Language
dc.contributor.author	Jha, NK
dc.contributor.author	Chen, W-C
dc.contributor.author	Kumar, S
dc.contributor.author	Dubey, R
dc.contributor.author	Tsai, L-W
dc.contributor.author	Kar, R
dc.contributor.author	Jha, SK
dc.contributor.author	Gupta, PK
dc.contributor.author	Sharma, A
dc.contributor.author	Gundamaraju, R
dc.contributor.author	Pant, K
dc.contributor.author	Mani, S
dc.contributor.author	Singh, SK
dc.contributor.author	Maccioni, RB
dc.contributor.author	Datta, T
dc.contributor.author	Singh, SK
dc.contributor.author	Gupta, G
dc.contributor.author	Prasher, P
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Dey, A
dc.contributor.author	Sharma, C
dc.contributor.author	Mughal, YH
dc.contributor.author	Ruokolainen, J
dc.contributor.author	Kesari, KK
dc.contributor.author	Ojha, S
dc.date.accessioned	2022-03-18T11:49:13Z
dc.date.available	2022-03-18T11:49:13Z
dc.date.issued	2022-03
dc.identifier.citation	Open Biology, 2022, 12, (3)
dc.identifier.issn	2046-2441
dc.identifier.uri	http://hdl.handle.net/10453/155359
dc.description.abstract	<jats:p>Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term ‘embryonic’ might appear to be a misnomer to several people because these pathways are functional during the early stages of embryonic development and adulthood, albeit to a certain degree. Therefore, any aberration in these pathways or their associated components may contribute towards a detrimental outcome in the form of neurological disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke. In the last decade, researchers have extensively studied these pathways to decipher disease-related interactions, which can be used as therapeutic targets to improve outcomes in patients with neurological abnormalities. However, a lot remains to be understood in this domain. Nevertheless, there is strong evidence supporting the fact that embryonic signalling is indeed a crucial mechanism as is manifested by its role in driving memory loss, motor impairments and many other processes after brain trauma. In this review, we explore the key roles of three embryonic pathways in modulating a range of homeostatic processes such as maintaining blood–brain barrier integrity, mitochondrial dynamics and neuroinflammation. In addition, we extensively investigated the effect of these pathways in driving the pathophysiology of a range of disorders such as Alzheimer's, Parkinson's and diabetic neuropathy. The concluding section of the review is dedicated to neurotherapeutics, wherein we identify and list a range of biological molecules and compounds that have shown enormous potential in improving prognosis in patients with these disorders.</jats:p>
dc.language	en
dc.publisher	The Royal Society
dc.relation.ispartof	Open Biology
dc.relation.isbasedon	10.1098/rsob.210289
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology, 0605 Microbiology, 1107 Immunology
dc.title	Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review
dc.type	Journal Article
utslib.citation.volume	12
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	0605 Microbiology
utslib.for	1107 Immunology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2022-03-18T11:49:11Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	12
utslib.citation.issue	3

Abstract:

Developmental signalling pathways such as Wnt/β-catenin, Notch and Sonic hedgehog play a central role in nearly all the stages of neuronal development. The term ‘embryonic’ might appear to be a misnomer to several people because these pathways are functional during the early stages of embryonic development and adulthood, albeit to a certain degree. Therefore, any aberration in these pathways or their associated components may contribute towards a detrimental outcome in the form of neurological disorders such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke. In the last decade, researchers have extensively studied these pathways to decipher disease-related interactions, which can be used as therapeutic targets to improve outcomes in patients with neurological abnormalities. However, a lot remains to be understood in this domain. Nevertheless, there is strong evidence supporting the fact that embryonic signalling is indeed a crucial mechanism as is manifested by its role in driving memory loss, motor impairments and many other processes after brain trauma. In this review, we explore the key roles of three embryonic pathways in modulating a range of homeostatic processes such as maintaining blood–brain barrier integrity, mitochondrial dynamics and neuroinflammation. In addition, we extensively investigated the effect of these pathways in driving the pathophysiology of a range of disorders such as Alzheimer's, Parkinson's and diabetic neuropathy. The concluding section of the review is dedicated to neurotherapeutics, wherein we identify and list a range of biological molecules and compounds that have shown enormous potential in improving prognosis in patients with these disorders.

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http://hdl.handle.net/10453/155359