An Examination of the Association Between Subjective Distress and Functional Connectivity During Discarding Decisions in Hoarding Disorder.

Levy, HC; Poppe, A; Hiser, J; Wootton, BM; Hallion, LS; Tolin, DF; Stevens, MC

An Examination of the Association Between Subjective Distress and Functional Connectivity During Discarding Decisions in Hoarding Disorder.

Levy, HC Poppe, A Hiser, J Wootton, BM Hallion, LS Tolin, DF Stevens, MC

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Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: Biol Psychiatry Cogn Neurosci Neuroimaging, 2021, 6, (10), pp. 1013-1022
Issue Date:: 2021-10

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Field	Value	Language
dc.contributor.author	Levy, HC
dc.contributor.author	Poppe, A
dc.contributor.author	Hiser, J
dc.contributor.author	Wootton, BM
dc.contributor.author	Hallion, LS
dc.contributor.author	Tolin, DF
dc.contributor.author	Stevens, MC
dc.date.accessioned	2022-03-29T21:10:19Z
dc.date.available	2020-12-23
dc.date.available	2022-03-29T21:10:19Z
dc.date.issued	2021-10
dc.identifier.citation	Biol Psychiatry Cogn Neurosci Neuroimaging, 2021, 6, (10), pp. 1013-1022
dc.identifier.issn	2451-9022
dc.identifier.issn	2451-9030
dc.identifier.uri	http://hdl.handle.net/10453/155672
dc.description.abstract	BACKGROUND: Individuals with hoarding disorder (HD) demonstrate exaggerated subjective distress and hyperactivation of cingulate and insular cortex regions when discarding personal possessions. No prior study has sought to determine whether this subjective distress is associated with specific profiles of abnormal brain function in individuals with HD. METHODS: We used multimodal canonical correlation analysis plus joint independent component analysis to test whether five hoarding-relevant domains of subjective distress when deciding to discard possessions (anxiety, sadness, monetary value, importance, and sentimental attachment) are associated with functional magnetic resonance imaging-measured whole-brain functional connectivity in 72 participants with HD and 44 healthy controls. RESULTS: Three extracted components differed between HD participants and healthy control subjects. Each of these components depicted an abnormal profile of functional connectivity in HD participants relative to control subjects during discarding decisions, and a specific distress response profile. One component pair showed a relationship between anxiety ratings during discarding decisions and connectivity among the pallidum, perirhinal ectorhinal cortex, and dorsolateral prefrontal cortex. Another component comprised sadness ratings during discarding decisions and connectivity in the pallidum, nucleus accumbens, amygdala, and dorsolateral prefrontal cortex. The third component linked HD brain connectivity in several dorsolateral prefrontal cortex regions with perceived importance ratings during discarding decisions. CONCLUSIONS: The findings indicate that in patients with HD, the subjective intensity of anxiety, sadness, and perceived possession importance is related to abnormal functional connectivity in key frontal and emotional processing brain regions. The findings are discussed in terms of emerging neurobiological models of HD.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER
dc.relation.ispartof	Biol Psychiatry Cogn Neurosci Neuroimaging
dc.relation.isbasedon	10.1016/j.bpsc.2020.12.014
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject.mesh	Anxiety
dc.subject.mesh	Anxiety Disorders
dc.subject.mesh	Emotions
dc.subject.mesh	Hoarding Disorder
dc.subject.mesh	Humans
dc.subject.mesh	Magnetic Resonance Imaging
dc.subject.mesh	Humans
dc.subject.mesh	Magnetic Resonance Imaging
dc.subject.mesh	Emotions
dc.subject.mesh	Anxiety
dc.subject.mesh	Anxiety Disorders
dc.subject.mesh	Hoarding Disorder
dc.title	An Examination of the Association Between Subjective Distress and Functional Connectivity During Discarding Decisions in Hoarding Disorder.
dc.type	Journal Article
utslib.citation.volume	6
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Clinical Psychology
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2022-10-01T00:00:00+1000Z
dc.date.updated	2022-03-29T21:10:15Z
pubs.issue	10
pubs.publication-status	Published
pubs.volume	6
utslib.citation.issue	10

Abstract:

BACKGROUND: Individuals with hoarding disorder (HD) demonstrate exaggerated subjective distress and hyperactivation of cingulate and insular cortex regions when discarding personal possessions. No prior study has sought to determine whether this subjective distress is associated with specific profiles of abnormal brain function in individuals with HD. METHODS: We used multimodal canonical correlation analysis plus joint independent component analysis to test whether five hoarding-relevant domains of subjective distress when deciding to discard possessions (anxiety, sadness, monetary value, importance, and sentimental attachment) are associated with functional magnetic resonance imaging-measured whole-brain functional connectivity in 72 participants with HD and 44 healthy controls. RESULTS: Three extracted components differed between HD participants and healthy control subjects. Each of these components depicted an abnormal profile of functional connectivity in HD participants relative to control subjects during discarding decisions, and a specific distress response profile. One component pair showed a relationship between anxiety ratings during discarding decisions and connectivity among the pallidum, perirhinal ectorhinal cortex, and dorsolateral prefrontal cortex. Another component comprised sadness ratings during discarding decisions and connectivity in the pallidum, nucleus accumbens, amygdala, and dorsolateral prefrontal cortex. The third component linked HD brain connectivity in several dorsolateral prefrontal cortex regions with perceived importance ratings during discarding decisions. CONCLUSIONS: The findings indicate that in patients with HD, the subjective intensity of anxiety, sadness, and perceived possession importance is related to abnormal functional connectivity in key frontal and emotional processing brain regions. The findings are discussed in terms of emerging neurobiological models of HD.

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