Relaxation and related therapies for people with multiple sclerosis (MS): A systematic review

Kneebone, II; Van Zanden, BE; Dorstyn, DS; Roberts, RM; Lord, SR; Querstret, D; Theadom, A; Kennedy, DS; Raman, J; Nair, RD

Relaxation and related therapies for people with multiple sclerosis (MS): A systematic review

Kneebone, II Van Zanden, BE Dorstyn, DS Roberts, RM Lord, SR Querstret, D Theadom, A Kennedy, DS Raman, J Nair, RD

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Publisher:: SAGE Publications
Publication Type:: Journal Article
Citation:: Clinical Rehabilitation, pp. 026921552210915-026921552210915

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Field	Value	Language
dc.contributor.author	Kneebone, II
dc.contributor.author	Van Zanden, BE
dc.contributor.author	Dorstyn, DS
dc.contributor.author	Roberts, RM
dc.contributor.author	Lord, SR
dc.contributor.author	Querstret, D
dc.contributor.author	Theadom, A
dc.contributor.author	Kennedy, DS
dc.contributor.author	Raman, J
dc.contributor.author	Nair, RD
dc.date.accessioned	2022-04-13T23:25:46Z
dc.date.available	2022-04-13T23:25:46Z
dc.identifier.citation	Clinical Rehabilitation, pp. 026921552210915-026921552210915
dc.identifier.issn	0269-2155
dc.identifier.issn	1477-0873
dc.identifier.uri	http://hdl.handle.net/10453/156232
dc.description.abstract	<jats:sec><jats:title>Objective</jats:title><jats:p> To establish the effectiveness of relaxation and related therapies in treating Multiple Sclerosis related symptoms and sequelae. </jats:p></jats:sec><jats:sec><jats:title>Data Sources</jats:title><jats:p> PsycINFO, PubMed, Embase, CINAHL, ProQuest Dissertations and Theses Global databases were searched. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> We included studies from database inception until 31 December 2021 involving adult participants diagnosed with multiple sclerosis or disseminated sclerosis, which featured quantitative data regarding the impact of relaxation interventions on multiple sclerosis-related symptoms and sequelae. Studies which examined multi-modal therapies - relaxation delivered in combination with non-relaxation interventions - were excluded. Risk of bias was assessed using the Revised Risk of Bias tool for randomised trials – ROB2, Risk of Bias in Non-Randomised Studies of Interventions ROBINS-I), and within and between-group effects were calculated (Hedges’ g). </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Twenty-eight studies met inclusion criteria. Twenty-three of these were randomised controlled trials, with 1246 total participants. This review reports on this data, with non-randomised study data reported in supplemental material. Post –intervention relaxation was associated with medium to large effect-size improvement for depression, anxiety, stress and fatigue. The effects of relaxation were superior to wait-list or no treatment control conditions; however, comparisons with established psychological or physical therapies were mixed. Individual studies reported sustained effects (≤ 6 months) with relaxation for stress, pain and quality of life. Most studies were rated as having a high/serious risk of bias. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> There is emerging evidence that relaxation therapies can improve outcomes for persons with multiple sclerosis. Given the high risk of bias found for included studies, stronger conclusions cannot be drawn. </jats:p></jats:sec>
dc.language	en
dc.publisher	SAGE Publications
dc.relation.ispartof	Clinical Rehabilitation
dc.relation.isbasedon	10.1177/02692155221091509
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	Authors: Ian I. Kneebone Article Title: Relaxation and related therapies for people with multiple sclerosis (MS): A systematic review. Journal Title: Clinical Rehabilitation Clinical Rehabilitation Date: 12 Apr 2022 Copyright © 2022 Sage Publications Reprinted by permission of SAGE Publications. Online version available on the SAGE Journals website https://doi.org/10.1177/02692155221091509
dc.subject	11 Medical and Health Sciences
dc.subject.classification	Rehabilitation
dc.title	Relaxation and related therapies for people with multiple sclerosis (MS): A systematic review
dc.type	Journal Article
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Clinical Psychology
utslib.copyright.status	open_access	*
dc.date.updated	2022-04-13T23:25:45Z
pubs.publication-status	Published online

Abstract:

Objective To establish the effectiveness of relaxation and related therapies in treating Multiple Sclerosis related symptoms and sequelae. Data Sources PsycINFO, PubMed, Embase, CINAHL, ProQuest Dissertations and Theses Global databases were searched. Methods We included studies from database inception until 31 December 2021 involving adult participants diagnosed with multiple sclerosis or disseminated sclerosis, which featured quantitative data regarding the impact of relaxation interventions on multiple sclerosis-related symptoms and sequelae. Studies which examined multi-modal therapies - relaxation delivered in combination with non-relaxation interventions - were excluded. Risk of bias was assessed using the Revised Risk of Bias tool for randomised trials – ROB2, Risk of Bias in Non-Randomised Studies of Interventions ROBINS-I), and within and between-group effects were calculated (Hedges’ g). Results Twenty-eight studies met inclusion criteria. Twenty-three of these were randomised controlled trials, with 1246 total participants. This review reports on this data, with non-randomised study data reported in supplemental material. Post –intervention relaxation was associated with medium to large effect-size improvement for depression, anxiety, stress and fatigue. The effects of relaxation were superior to wait-list or no treatment control conditions; however, comparisons with established psychological or physical therapies were mixed. Individual studies reported sustained effects (≤ 6 months) with relaxation for stress, pain and quality of life. Most studies were rated as having a high/serious risk of bias. Conclusion There is emerging evidence that relaxation therapies can improve outcomes for persons with multiple sclerosis. Given the high risk of bias found for included studies, stronger conclusions cannot be drawn.

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http://hdl.handle.net/10453/156232