Pharmacological Evaluation of the Recuperative Effect of Morusin Against Aluminium Trichloride (AlCl3)-Induced Memory Impairment in Rats.
- Publisher:
- Bentham Science Publishers Ltd.
- Publication Type:
- Journal Article
- Citation:
- Cent Nerv Syst Agents Med Chem, 2017, 17, (3), pp. 196-200
- Issue Date:
- 2017
Closed Access
Filename | Description | Size | |||
---|---|---|---|---|---|
Gaurav Gupta CNSA-MC MS 2nd.pdf | Published version | 636.34 kB | Adobe PDF |
Copyright Clearance Process
- Recently Added
- In Progress
- Closed Access
This item is closed access and not available.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Gupta, G | |
dc.contributor.author | Chellappan, DK | |
dc.contributor.author | Agarwal, M | |
dc.contributor.author | Ashwathanarayana, M | |
dc.contributor.author | Nammi, S | |
dc.contributor.author | Pabreja, K | |
dc.contributor.author |
Dua, K |
|
dc.date.accessioned | 2022-04-27T23:20:33Z | |
dc.date.available | 2016-11-02 | |
dc.date.available | 2022-04-27T23:20:33Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Cent Nerv Syst Agents Med Chem, 2017, 17, (3), pp. 196-200 | |
dc.identifier.issn | 1871-5249 | |
dc.identifier.issn | 1875-6166 | |
dc.identifier.uri | http://hdl.handle.net/10453/156709 | |
dc.description.abstract | BACKGROUND: Elevation in brain levels of aluminium can be neurotoxic and can cause learning and memory deficiencies. In Chinese medicine, Morus alba is used as a neuroprotective herb. The current study was intended to discover the recuperative effect of morusin against aluminium trichloride (AlCl3)-induced memory impairment in rats along with biochemical mechanism of its protective action. METHODS: Memory deficiency was produced by AlCl3 (100 mg/kg; p.o.) in experimental animals. Learning and memory activity was measured using Morris water maze (MWM) test model. Central cholinergic activity was evaluated through the measurement of brain acetylcholinesterase (AChE) activity. In addition to the above, oxidative stress was determined through assessment of brain thiobarbituric acid-reactive species (TBARS) and glutathione (GSH) levels. RESULTS: AlCl3 administration prompted significant deficiency of learning and memory in rats, as specified by a noticeable reduction in MWM presentation. AlCl3 administration also produced a significant deterioration in brain AChE action and brain oxidative stress (increase in TBARS and decrease in GSH) levels. Treatment with morusin (5.0 and 10.0 mg/kg, dose orally) significantly overturned AlCl3- induced learning and memory shortages along with diminution of AlCl3-induced rise in brain AChE activity and brain oxidative stress levels. CONCLUSION: It may be concluded that morusin exerts a memory-preservative outcome in mental discrepancies of rats feasibly through its various activities. | |
dc.format | ||
dc.language | eng | |
dc.publisher | Bentham Science Publishers Ltd. | |
dc.relation.ispartof | Cent Nerv Syst Agents Med Chem | |
dc.relation.isbasedon | 10.2174/1871524917666161111095335 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject.classification | Neurology & Neurosurgery | |
dc.subject.mesh | Aluminum Chloride | |
dc.subject.mesh | Aluminum Compounds | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Chlorides | |
dc.subject.mesh | Drug Evaluation, Preclinical | |
dc.subject.mesh | Drugs, Chinese Herbal | |
dc.subject.mesh | Flavonoids | |
dc.subject.mesh | Male | |
dc.subject.mesh | Memory Disorders | |
dc.subject.mesh | Morus | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, Wistar | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, Wistar | |
dc.subject.mesh | Morus | |
dc.subject.mesh | Memory Disorders | |
dc.subject.mesh | Aluminum Compounds | |
dc.subject.mesh | Chlorides | |
dc.subject.mesh | Flavonoids | |
dc.subject.mesh | Drugs, Chinese Herbal | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Drug Evaluation, Preclinical | |
dc.subject.mesh | Male | |
dc.subject.mesh | Aluminum Chloride | |
dc.title | Pharmacological Evaluation of the Recuperative Effect of Morusin Against Aluminium Trichloride (AlCl3)-Induced Memory Impairment in Rats. | |
dc.type | Journal Article | |
utslib.citation.volume | 17 | |
utslib.location.activity | United Arab Emirates | |
utslib.for | 1115 Pharmacology and Pharmaceutical Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health/Graduate School of Health | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2022-04-27T23:20:31Z | |
pubs.issue | 3 | |
pubs.publication-status | Published | |
pubs.volume | 17 | |
utslib.citation.issue | 3 |
Abstract:
BACKGROUND: Elevation in brain levels of aluminium can be neurotoxic and can cause learning and memory deficiencies. In Chinese medicine, Morus alba is used as a neuroprotective herb. The current study was intended to discover the recuperative effect of morusin against aluminium trichloride (AlCl3)-induced memory impairment in rats along with biochemical mechanism of its protective action. METHODS: Memory deficiency was produced by AlCl3 (100 mg/kg; p.o.) in experimental animals. Learning and memory activity was measured using Morris water maze (MWM) test model. Central cholinergic activity was evaluated through the measurement of brain acetylcholinesterase (AChE) activity. In addition to the above, oxidative stress was determined through assessment of brain thiobarbituric acid-reactive species (TBARS) and glutathione (GSH) levels. RESULTS: AlCl3 administration prompted significant deficiency of learning and memory in rats, as specified by a noticeable reduction in MWM presentation. AlCl3 administration also produced a significant deterioration in brain AChE action and brain oxidative stress (increase in TBARS and decrease in GSH) levels. Treatment with morusin (5.0 and 10.0 mg/kg, dose orally) significantly overturned AlCl3- induced learning and memory shortages along with diminution of AlCl3-induced rise in brain AChE activity and brain oxidative stress levels. CONCLUSION: It may be concluded that morusin exerts a memory-preservative outcome in mental discrepancies of rats feasibly through its various activities.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph