Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Awasthi, A; Gulati, M; Kumar, B; Kaur, J; Vishwas, S; Khursheed, R; Porwal, O; Alam, A; KR, A; Corrie, L; Kumar, R; Kumar, A; Kaushik, M; Jha, NK; Gupta, PK; Chellappan, DK; Gupta, G; Dua, K; Gupta, S; Gundamaraju, R; Rao, PV; Singh, SK

Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds

Awasthi, A Gulati, M Kumar, B Kaur, J Vishwas, S Khursheed, R Porwal, O Alam, A KR, A Corrie, L Kumar, R Kumar, A Kaushik, M Jha, NK Gupta, PK Chellappan, DK Gupta, G Dua, K

Gupta, S Gundamaraju, R Rao, PV Singh, SK

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Publisher:: Hindawi Limited
Publication Type:: Journal Article
Citation:: BioMed Research International, 2022, 2022, pp. 1-43
Issue Date:: 2022-07-04

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Field	Value	Language
dc.contributor.author	Awasthi, A
dc.contributor.author	Gulati, M
dc.contributor.author	Kumar, B
dc.contributor.author	Kaur, J
dc.contributor.author	Vishwas, S
dc.contributor.author	Khursheed, R
dc.contributor.author	Porwal, O
dc.contributor.author	Alam, A
dc.contributor.author	KR, A
dc.contributor.author	Corrie, L
dc.contributor.author	Kumar, R
dc.contributor.author	Kumar, A
dc.contributor.author	Kaushik, M
dc.contributor.author	Jha, NK
dc.contributor.author	Gupta, PK
dc.contributor.author	Chellappan, DK
dc.contributor.author	Gupta, G
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Gupta, S
dc.contributor.author	Gundamaraju, R
dc.contributor.author	Rao, PV
dc.contributor.author	Singh, SK
dc.date.accessioned	2022-07-05T12:04:24Z
dc.date.available	2022-07-05T12:04:24Z
dc.date.issued	2022-07-04
dc.identifier.citation	BioMed Research International, 2022, 2022, pp. 1-43
dc.identifier.issn	2314-6133
dc.identifier.issn	2314-6141
dc.identifier.uri	http://hdl.handle.net/10453/158672
dc.description.abstract	<jats:p>Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide- and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW.</jats:p>
dc.language	en
dc.publisher	Hindawi Limited
dc.relation.ispartof	BioMed Research International
dc.relation.isbasedon	10.1155/2022/1659338
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	06 Biological Sciences, 08 Information and Computing Sciences, 10 Technology
dc.title	Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds
dc.type	Journal Article
utslib.citation.volume	2022
utslib.for	06 Biological Sciences
utslib.for	08 Information and Computing Sciences
utslib.for	10 Technology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2022-07-05T12:04:22Z
pubs.publication-status	Published
pubs.volume	2022

Abstract:

Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide- and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW.

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http://hdl.handle.net/10453/158672