Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer.

Palmer, S; Litvinova, K; Dunaev, A; Fleming, S; McGloin, D; Nabi, G

Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer.

Palmer, S Litvinova, K Dunaev, A Fleming, S McGloin, D

Nabi, G

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Publisher:: OPTICAL SOC AMER
Publication Type:: Journal Article
Citation:: Biomed Opt Express, 2016, 7, (4), pp. 1193-1200
Issue Date:: 2016-04-01

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Field	Value	Language
dc.contributor.author	Palmer, S
dc.contributor.author	Litvinova, K
dc.contributor.author	Dunaev, A
dc.contributor.author	Fleming, S
dc.contributor.author	McGloin, D https://orcid.org/0000-0002-0075-4481
dc.contributor.author	Nabi, G
dc.date.accessioned	2022-07-13T05:42:08Z
dc.date.available	2016-02-13
dc.date.available	2022-07-13T05:42:08Z
dc.date.issued	2016-04-01
dc.identifier.citation	Biomed Opt Express, 2016, 7, (4), pp. 1193-1200
dc.identifier.issn	2156-7085
dc.identifier.issn	2156-7085
dc.identifier.uri	http://hdl.handle.net/10453/158852
dc.description.abstract	Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	OPTICAL SOC AMER
dc.relation.ispartof	Biomed Opt Express
dc.relation.isbasedon	10.1364/BOE.7.001193
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0205 Optical Physics, 0912 Materials Engineering
dc.title	Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer.
dc.type	Journal Article
utslib.citation.volume	7
utslib.location.activity	United States
utslib.for	0205 Optical Physics
utslib.for	0912 Materials Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
utslib.copyright.status	closed_access	*
dc.date.updated	2022-07-13T05:42:04Z
pubs.issue	4
pubs.publication-status	Published online
pubs.volume	7
utslib.citation.issue	4

Abstract:

Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

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http://hdl.handle.net/10453/158852