White matter connectivity in neonates at risk of stuttering: Preliminary data
- Publisher:
- ELSEVIER IRELAND LTD
- Publication Type:
- Journal Article
- Citation:
- Neuroscience Letters, 2022, 781, pp. 136655
- Issue Date:
- 2022-04-01
Closed Access
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1-s2.0-S0304394022002129-main.pdf | 2.96 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author |
Packman, A https://orcid.org/0000-0001-7378-326X |
|
dc.contributor.author |
Onslow, M https://orcid.org/0000-0003-2629-2390 |
|
dc.contributor.author | Lagopoulos, J | |
dc.contributor.author | Shan, ZY | |
dc.contributor.author |
Lowe, R https://orcid.org/0000-0003-3826-5306 |
|
dc.contributor.author | Jones, M | |
dc.contributor.author |
O'Brian, S https://orcid.org/0000-0002-0882-1909 |
|
dc.contributor.author | Sommer, M | |
dc.date.accessioned | 2022-08-02T06:03:51Z | |
dc.date.available | 2022-04-20 | |
dc.date.available | 2022-08-02T06:03:51Z | |
dc.date.issued | 2022-04-01 | |
dc.identifier.citation | Neuroscience Letters, 2022, 781, pp. 136655 | |
dc.identifier.issn | 0304-3940 | |
dc.identifier.issn | 1872-7972 | |
dc.identifier.uri | http://hdl.handle.net/10453/159489 | |
dc.description.abstract | BACKGROUND: Developmental stuttering is thought to be underpinned by structural impairments in the brain. The only way to support the claim that these are causal is to determine if they are present before onset. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) was conducted on 18 neonates, aged 8-18 weeks, 6 of whom were determined to be genetically at risk of stuttering. RESULTS: With tract-based spatial statistics (TBSS) analysis, no statistically significant differences were found between the at-risk group and the control group. However, fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) in the corpus callosum of the at-risk group were lower (uncorrected) than in the control group. Automated Fiber Quantification (AFQ) yielded lower FA in the at-risk group than in the control group in the medial section of the callosum forceps minor. DISCUSSION: The findings, albeit with a small number of participants, support the proposition that reduced integrity of white matter in the corpus callosum has a causal role in developmental stuttering. Longitudinal research to determine if children with this impairment at birth later start to stutter is needed to confirm this. The left arcuate fasciculus is thought to develop as speech develops, which likely explains why there were no abnormal findings in this area in our at-risk neonates so soon after birth. This is the first study to investigate the brains of children before the onset of stuttering, and the findings warrant further research. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | ELSEVIER IRELAND LTD | |
dc.relation | http://purl.org/au-research/grants/arc/DP150101353 | |
dc.relation.ispartof | Neuroscience Letters | |
dc.relation.isbasedon | 10.1016/j.neulet.2022.136655 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences | |
dc.subject.mesh | Anisotropy | |
dc.subject.mesh | Brain | |
dc.subject.mesh | Child | |
dc.subject.mesh | Corpus Callosum | |
dc.subject.mesh | Diffusion Tensor Imaging | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Infant, Newborn | |
dc.subject.mesh | Preliminary Data | |
dc.subject.mesh | Stuttering | |
dc.subject.mesh | White Matter | |
dc.subject.mesh | Brain | |
dc.subject.mesh | Corpus Callosum | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Stuttering | |
dc.subject.mesh | Anisotropy | |
dc.subject.mesh | Child | |
dc.subject.mesh | Infant, Newborn | |
dc.subject.mesh | Diffusion Tensor Imaging | |
dc.subject.mesh | White Matter | |
dc.subject.mesh | Preliminary Data | |
dc.title | White matter connectivity in neonates at risk of stuttering: Preliminary data | |
dc.type | Journal Article | |
utslib.citation.volume | 781 | |
utslib.location.activity | Ireland | |
utslib.for | 1109 Neurosciences | |
utslib.for | 1701 Psychology | |
utslib.for | 1702 Cognitive Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
pubs.organisational-group | /University of Technology Sydney/Strength - ASRC Australian Stuttering Research Centre | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health/Graduate School of Health | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Australian Stuttering Research Centre | |
utslib.copyright.status | closed_access | * |
pubs.consider-herdc | true | |
dc.date.updated | 2022-08-02T06:03:49Z | |
pubs.publication-status | Published | |
pubs.volume | 781 |
Abstract:
BACKGROUND: Developmental stuttering is thought to be underpinned by structural impairments in the brain. The only way to support the claim that these are causal is to determine if they are present before onset. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) was conducted on 18 neonates, aged 8-18 weeks, 6 of whom were determined to be genetically at risk of stuttering. RESULTS: With tract-based spatial statistics (TBSS) analysis, no statistically significant differences were found between the at-risk group and the control group. However, fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) in the corpus callosum of the at-risk group were lower (uncorrected) than in the control group. Automated Fiber Quantification (AFQ) yielded lower FA in the at-risk group than in the control group in the medial section of the callosum forceps minor. DISCUSSION: The findings, albeit with a small number of participants, support the proposition that reduced integrity of white matter in the corpus callosum has a causal role in developmental stuttering. Longitudinal research to determine if children with this impairment at birth later start to stutter is needed to confirm this. The left arcuate fasciculus is thought to develop as speech develops, which likely explains why there were no abnormal findings in this area in our at-risk neonates so soon after birth. This is the first study to investigate the brains of children before the onset of stuttering, and the findings warrant further research.
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