Using curtain flow second-generation silica monoliths to improve separations at pressures less than 400 bar

Soliven, A; Pravadali-Cekic, S; Foley, D; Pereira, L; Dennis, GR; Cabrera, K; Ritchie, H; Edge, T; Shalliker, RA

Using curtain flow second-generation silica monoliths to improve separations at pressures less than 400 bar

Soliven, A Pravadali-Cekic, S Foley, D Pereira, L Dennis, GR Cabrera, K Ritchie, H Edge, T Shalliker, RA

Permalink

Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Microchemical Journal, 2016, 127, pp. 68-73
Issue Date:: 2016-07-01

Closed Access

	Filename	Description	Size
	1-s2.0-S0026265X1600028X-main.pdf	Published version	1.19 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Soliven, A
dc.contributor.author	Pravadali-Cekic, S
dc.contributor.author	Foley, D
dc.contributor.author	Pereira, L
dc.contributor.author	Dennis, GR
dc.contributor.author	Cabrera, K
dc.contributor.author	Ritchie, H
dc.contributor.author	Edge, T
dc.contributor.author	Shalliker, RA
dc.date.accessioned	2022-08-14T02:17:16Z
dc.date.available	2022-08-14T02:17:16Z
dc.date.issued	2016-07-01
dc.identifier.citation	Microchemical Journal, 2016, 127, pp. 68-73
dc.identifier.issn	0026-265X
dc.identifier.uri	http://hdl.handle.net/10453/160113
dc.description.abstract	The performance of a second-generation analytical-scale silica monolith utilizing the curtain flow (CF) column design was studied for the first time. The performance of the CF column was compared to a conventional monolith column under isocratic conditions, and the new column achieved a gain in theoretical plates by as much as 50%, with almost Gaussian bands being obtained (asymmetry factor of 1.02). Detection sensitivity increased by as much as 125% under optimal detection conditions. The sensitivity and performance was also chromatographically compared to a core-shell column under both gradient and isocratic elution for a model compound (polystyrene) and a natural product (coffee sample) with sensitivity gains of up to 365%. The second-generation monolithic CF column is an excellent tool that can be tuned to provide highly efficient, highly sensitive, high-throughput, and low volumetric detection analyses, using conventional HPLC systems.
dc.language	en
dc.publisher	Elsevier BV
dc.relation.ispartof	Microchemical Journal
dc.relation.isbasedon	10.1016/j.microc.2016.02.007
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0301 Analytical Chemistry
dc.subject.classification	Analytical Chemistry
dc.title	Using curtain flow second-generation silica monoliths to improve separations at pressures less than 400 bar
dc.type	Journal Article
utslib.citation.volume	127
utslib.for	0301 Analytical Chemistry
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-14T02:17:15Z
pubs.publication-status	Published
pubs.volume	127

Abstract:

The performance of a second-generation analytical-scale silica monolith utilizing the curtain flow (CF) column design was studied for the first time. The performance of the CF column was compared to a conventional monolith column under isocratic conditions, and the new column achieved a gain in theoretical plates by as much as 50%, with almost Gaussian bands being obtained (asymmetry factor of 1.02). Detection sensitivity increased by as much as 125% under optimal detection conditions. The sensitivity and performance was also chromatographically compared to a core-shell column under both gradient and isocratic elution for a model compound (polystyrene) and a natural product (coffee sample) with sensitivity gains of up to 365%. The second-generation monolithic CF column is an excellent tool that can be tuned to provide highly efficient, highly sensitive, high-throughput, and low volumetric detection analyses, using conventional HPLC systems.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/160113