Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats

Puri, V; Sharma, A; Kumar, P; Dua, K; Huanbutta, K; Singh, I; Sangnim, T

Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats

Puri, V Sharma, A Kumar, P Dua, K

Huanbutta, K Singh, I Sangnim, T

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Polymers, 14, (18), pp. 3836-3836

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Field	Value	Language
dc.contributor.author	Puri, V
dc.contributor.author	Sharma, A
dc.contributor.author	Kumar, P
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Huanbutta, K
dc.contributor.author	Singh, I
dc.contributor.author	Sangnim, T
dc.date.accessioned	2022-09-16T11:38:37Z
dc.date.available	2022-09-16T11:38:37Z
dc.identifier.citation	Polymers, 14, (18), pp. 3836-3836
dc.identifier.issn	2073-4360
dc.identifier.uri	http://hdl.handle.net/10453/161857
dc.description.abstract	<jats:p>Various drug delivery systems were developed using a modified form of gum ghatti. Modifying gum ghatti using thioglycolic acid improves its mucoadhesive property, and hence, it is a suitable approach for the fabrication and development of controlled drug delivery systems. In accordance with regulatory guidelines, namely, the Organization for Economic Co-operation and Development’s (OECD) 423 guidelines, an acute oral dose toxicity study was performed to examine the toxicological effects of gum ghattiin an animal (Wistar rat) after a single oral dose administration of pure gum ghatti and thiolated gum ghatti. Orally administered pure and thiolated gum ghatti do not reveal any considerable change in the behavioral pattern, food intake, body weight, hematology, or clinical symptoms of treated animals. Furthermore, histopathological studies showed no pathological mutations in the vital organs of Wistar rats after the oral administration of single doses of both types of gumghatti (i.e., 300 mg/kg and 2000 mg/kg body weight). Whole blood clotting studies showed the low absorbance value of the modified gum (thiolated gum ghatti) in contrast to the pure gum and control, hence demonstrating its excellent clotting capability. The aforementioned toxicological study suggested that the oral administration of a single dose of pure and thiolated gum ghatti did not produce any toxicological effects in Wistar rats. Consequently, it could be a suitable and safe candidate for formulating various drug delivery systems.</jats:p>
dc.language	en
dc.publisher	MDPI AG
dc.relation.ispartof	Polymers
dc.relation.isbasedon	10.3390/polym14183836
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	03 Chemical Sciences, 09 Engineering
dc.title	Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats
dc.type	Journal Article
utslib.citation.volume	14
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	open_access	*
dc.date.updated	2022-09-16T11:38:35Z
pubs.issue	18
pubs.publication-status	Published online
pubs.volume	14
utslib.citation.issue	18

Abstract:

Various drug delivery systems were developed using a modified form of gum ghatti. Modifying gum ghatti using thioglycolic acid improves its mucoadhesive property, and hence, it is a suitable approach for the fabrication and development of controlled drug delivery systems. In accordance with regulatory guidelines, namely, the Organization for Economic Co-operation and Development’s (OECD) 423 guidelines, an acute oral dose toxicity study was performed to examine the toxicological effects of gum ghattiin an animal (Wistar rat) after a single oral dose administration of pure gum ghatti and thiolated gum ghatti. Orally administered pure and thiolated gum ghatti do not reveal any considerable change in the behavioral pattern, food intake, body weight, hematology, or clinical symptoms of treated animals. Furthermore, histopathological studies showed no pathological mutations in the vital organs of Wistar rats after the oral administration of single doses of both types of gumghatti (i.e., 300 mg/kg and 2000 mg/kg body weight). Whole blood clotting studies showed the low absorbance value of the modified gum (thiolated gum ghatti) in contrast to the pure gum and control, hence demonstrating its excellent clotting capability. The aforementioned toxicological study suggested that the oral administration of a single dose of pure and thiolated gum ghatti did not produce any toxicological effects in Wistar rats. Consequently, it could be a suitable and safe candidate for formulating various drug delivery systems.

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http://hdl.handle.net/10453/161857