KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.

Hortle, E; Starrs, L; Brown, FC; Jane, SM; Curtis, DJ; McMorran, BJ; Foote, SJ; Burgio, G

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.

Hortle, E

Starrs, L Brown, FC Jane, SM Curtis, DJ McMorran, BJ Foote, SJ Burgio, G

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Publisher:: NATURE PUBLISHING GROUP
Publication Type:: Journal Article
Citation:: Sci Rep, 2019, 9, (1), pp. 6356
Issue Date:: 2019-04-23

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Field	Value	Language
dc.contributor.author	Hortle, E https://orcid.org/0000-0001-9633-5638
dc.contributor.author	Starrs, L
dc.contributor.author	Brown, FC
dc.contributor.author	Jane, SM
dc.contributor.author	Curtis, DJ
dc.contributor.author	McMorran, BJ
dc.contributor.author	Foote, SJ
dc.contributor.author	Burgio, G
dc.date.accessioned	2022-10-11T00:29:29Z
dc.date.available	2019-04-08
dc.date.available	2022-10-11T00:29:29Z
dc.date.issued	2019-04-23
dc.identifier.citation	Sci Rep, 2019, 9, (1), pp. 6356
dc.identifier.issn	2045-2322
dc.identifier.issn	2045-2322
dc.identifier.uri	http://hdl.handle.net/10453/162450
dc.description.abstract	Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines. Recently K+ signaling has emerged as an important mediator of the inflammatory response to infection; we therefore investigated whether mice carrying an ENU induced activation of the electroneutral K+ channel KCC1 had an altered response to Plasmodium berghei. Here we show that Kcc1M935K/M935K mice are protected from the development of experimental cerebral malaria, and that this protection is associated with an increased CD4+ and TNFa response. This is the first description of a K+ channel affecting the development of experimental cerebral malaria.
dc.format	Electronic
dc.language	eng
dc.publisher	NATURE PUBLISHING GROUP
dc.relation.ispartof	Sci Rep
dc.relation.isbasedon	10.1038/s41598-019-42782-x
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Animals
dc.subject.mesh	CD4-Positive T-Lymphocytes
dc.subject.mesh	CD8-Positive T-Lymphocytes
dc.subject.mesh	Cytokines
dc.subject.mesh	Disease Resistance
dc.subject.mesh	Female
dc.subject.mesh	Inflammation Mediators
dc.subject.mesh	Ion Channel Gating
dc.subject.mesh	Malaria, Cerebral
dc.subject.mesh	Male
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Mice, Inbred C57BL
dc.subject.mesh	Mutation
dc.subject.mesh	Plasmodium berghei
dc.subject.mesh	Solute Carrier Family 12, Member 4
dc.subject.mesh	CD4-Positive T-Lymphocytes
dc.subject.mesh	CD8-Positive T-Lymphocytes
dc.subject.mesh	Animals
dc.subject.mesh	Mice, Inbred BALB C
dc.subject.mesh	Mice, Inbred C57BL
dc.subject.mesh	Plasmodium berghei
dc.subject.mesh	Malaria, Cerebral
dc.subject.mesh	Inflammation Mediators
dc.subject.mesh	Cytokines
dc.subject.mesh	Ion Channel Gating
dc.subject.mesh	Mutation
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Disease Resistance
dc.subject.mesh	Solute Carrier Family 12, Member 4
dc.title	KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2022-10-11T00:28:38Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	9
utslib.citation.issue	1

Abstract:

Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines. Recently K+ signaling has emerged as an important mediator of the inflammatory response to infection; we therefore investigated whether mice carrying an ENU induced activation of the electroneutral K+ channel KCC1 had an altered response to Plasmodium berghei. Here we show that Kcc1M935K/M935K mice are protected from the development of experimental cerebral malaria, and that this protection is associated with an increased CD4+ and TNFa response. This is the first description of a K+ channel affecting the development of experimental cerebral malaria.

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http://hdl.handle.net/10453/162450