Pathogen adaptation to vaccination: The Australian Bordetella pertussis story

Luu, LDW

Pathogen adaptation to vaccination: The Australian Bordetella pertussis story

Luu, LDW

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Publisher:: CSIRO Publishing
Publication Type:: Journal Article
Citation:: Microbiology Australia, 2019, 40, (4), pp. 177-180
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Luu, LDW
dc.date.accessioned	2022-10-30T01:54:42Z
dc.date.available	2022-10-30T01:54:42Z
dc.date.issued	2019-01-01
dc.identifier.citation	Microbiology Australia, 2019, 40, (4), pp. 177-180
dc.identifier.issn	1324-4272
dc.identifier.issn	2201-9189
dc.identifier.uri	http://hdl.handle.net/10453/162899
dc.description.abstract	Whooping cough (pertussis) is a highly contagious vaccine preventable respiratory disease caused by the Gram-negative bacterium Bordetella pertussis. Despite high level vaccination coverage over the past 20 years, Australia has one of the highest per capita burdens of pertussis globally. Oneof theprimaryfactors associated withthere-emergence of pertussis is pathogen adaptation of B. pertussis to the current acellular vaccines used. This article will focusonthe genomic and proteomic changes that have occurred in the Australian B. pertussis population, the significance of these adaptive changes on fitness in a vaccinated environment and what we can do to reduce the significant burden of pertussis in the future.
dc.language	en
dc.publisher	CSIRO Publishing
dc.relation.ispartof	Microbiology Australia
dc.relation.isbasedon	10.1071/MA19052
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology, 0605 Microbiology
dc.title	Pathogen adaptation to vaccination: The Australian Bordetella pertussis story
dc.type	Journal Article
utslib.citation.volume	40
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	0605 Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-10-30T01:54:41Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	40
utslib.citation.issue	4

Abstract:

Whooping cough (pertussis) is a highly contagious vaccine preventable respiratory disease caused by the Gram-negative bacterium Bordetella pertussis. Despite high level vaccination coverage over the past 20 years, Australia has one of the highest per capita burdens of pertussis globally. Oneof theprimaryfactors associated withthere-emergence of pertussis is pathogen adaptation of B. pertussis to the current acellular vaccines used. This article will focusonthe genomic and proteomic changes that have occurred in the Australian B. pertussis population, the significance of these adaptive changes on fitness in a vaccinated environment and what we can do to reduce the significant burden of pertussis in the future.

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http://hdl.handle.net/10453/162899