Effects of Exercise on Skeletal Muscle Pathophysiology in Huntington's Disease.

Trovato, B; Magrì, B; Castorina, A; Maugeri, G; D'Agata, V; Musumeci, G

Effects of Exercise on Skeletal Muscle Pathophysiology in Huntington's Disease.

Trovato, B Magrì, B Castorina, A

Maugeri, G D'Agata, V Musumeci, G

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Journal of Functional Morphology and Kinesiology, 2022, 7, (2), pp. 1-13
Issue Date:: 2022-05-11

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Field	Value	Language
dc.contributor.author	Trovato, B
dc.contributor.author	Magrì, B
dc.contributor.author	Castorina, A https://orcid.org/0000-0001-7037-759X
dc.contributor.author	Maugeri, G
dc.contributor.author	D'Agata, V
dc.contributor.author	Musumeci, G
dc.date.accessioned	2022-11-07T04:23:10Z
dc.date.available	2022-05-09
dc.date.available	2022-11-07T04:23:10Z
dc.date.issued	2022-05-11
dc.identifier.citation	Journal of Functional Morphology and Kinesiology, 2022, 7, (2), pp. 1-13
dc.identifier.issn	2411-5142
dc.identifier.issn	2411-5142
dc.identifier.uri	http://hdl.handle.net/10453/163279
dc.description.abstract	Huntington's disease (HD) is a rare, hereditary, and progressive neurodegenerative disease, characterized by involuntary choreatic movements with cognitive and behavioral disturbances. In order to mitigate impairments in motor function, physical exercise was integrated in HD rehabilitative interventions, showing to be a powerful tool to ameliorate the quality of life of HD-affected patients. This review aims to describe the effects of physical exercise on HD-related skeletal muscle disorders in both murine and human models. We performed a literature search using PubMed, Scopus, and Web of Science databases on the role of physical activity in mouse models of HD and human patients. Fifteen publications fulfilled the criteria and were included in the review. Studies performed on mouse models showed a controversial role played by exercise, whereas in HD-affected patients, physical activity appeared to have positive effects on gait, motor function, UHDMRS scale, cognitive function, quality of life, postural stability, total body mass, fatty acid oxidative capacity, and VO2 max. Physical activity seems to be feasible, safe, and effective for HD patients. However, further studies with longer follow-up and larger cohorts of patients will be needed to draw firm conclusions on the positive effects of exercise for HD patients.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Journal of Functional Morphology and Kinesiology
dc.relation.isbasedon	10.3390/jfmk7020040
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Effects of Exercise on Skeletal Muscle Pathophysiology in Huntington's Disease.
dc.type	Journal Article
utslib.citation.volume	7
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-07T04:23:07Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	7
utslib.citation.issue	2

Abstract:

Huntington's disease (HD) is a rare, hereditary, and progressive neurodegenerative disease, characterized by involuntary choreatic movements with cognitive and behavioral disturbances. In order to mitigate impairments in motor function, physical exercise was integrated in HD rehabilitative interventions, showing to be a powerful tool to ameliorate the quality of life of HD-affected patients. This review aims to describe the effects of physical exercise on HD-related skeletal muscle disorders in both murine and human models. We performed a literature search using PubMed, Scopus, and Web of Science databases on the role of physical activity in mouse models of HD and human patients. Fifteen publications fulfilled the criteria and were included in the review. Studies performed on mouse models showed a controversial role played by exercise, whereas in HD-affected patients, physical activity appeared to have positive effects on gait, motor function, UHDMRS scale, cognitive function, quality of life, postural stability, total body mass, fatty acid oxidative capacity, and VO2 max. Physical activity seems to be feasible, safe, and effective for HD patients. However, further studies with longer follow-up and larger cohorts of patients will be needed to draw firm conclusions on the positive effects of exercise for HD patients.

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http://hdl.handle.net/10453/163279