Recent advances in flavonoid-based nanocarriers as an emerging drug delivery approach for cancer chemotherapy.
- Publisher:
- Elsevier BV
- Publication Type:
- Journal Article
- Citation:
- Drug Discov Today, 2022, pp. 103409
- Issue Date:
- 2022-10-17
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Flavonoid-based nanocarriers_1-s2.0-S1359644622004020-main.pdf | Published version | 2.79 MB |
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Flavonoids are an interesting class of biomolecules that exhibit cancer-inhibitory effects through both chemopreventive and chemotherapeutic activities. However, poor pharmacokinetics (PK) and biopharmaceutical attributes affect their therapeutic efficacy. One of the most promising approaches to resolve these issues is to formulate flavonoids in nanosystems. Different flavonoid nanoformulations have shown therapeutic superiority over free flavonoids. Functionalization of nanoparticles (NPs) further improves their therapeutic efficacy by facilitating site-specific delivery and reducing nonspecific toxicities. In this review, we highlight recent developments in the field of flavonoid-based NPs to gain translational insights into the potential applications of flavonoid-based nanocarriers in cancer management.
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