A brief history of brain iron accumulation in Parkinson disease and related disorders.

Foley, PB; Hare, DJ; Double, KL

A brief history of brain iron accumulation in Parkinson disease and related disorders.

Foley, PB Hare, DJ Double, KL

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Publisher:: Springer
Publication Type:: Journal Article
Citation:: Journal of Neural Transmission, 2022, 129, (5-6), pp. 505-520
Issue Date:: 2022-06

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Field	Value	Language
dc.contributor.author	Foley, PB
dc.contributor.author	Hare, DJ
dc.contributor.author	Double, KL
dc.date.accessioned	2022-11-22T02:41:26Z
dc.date.available	2022-04-22
dc.date.available	2022-11-22T02:41:26Z
dc.date.issued	2022-06
dc.identifier.citation	Journal of Neural Transmission, 2022, 129, (5-6), pp. 505-520
dc.identifier.issn	0300-9564
dc.identifier.issn	1435-1463
dc.identifier.uri	http://hdl.handle.net/10453/163644
dc.description.abstract	Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for normal brain function, but abnormal brain iron accumulation has been associated with extrapyramidal disease for a century. Precisely why, how, and when iron is implicated in neuronal death remains the subject of investigation. In this article, we review the history of iron in movement disorders, from the first observations in the early twentieth century to recent efforts that view extrapyramidal iron as a novel therapeutic target and diagnostic indicator.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer
dc.relation.ispartof	Journal of Neural Transmission
dc.relation.isbasedon	10.1007/s00702-022-02505-5
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1109 Neurosciences, 1701 Psychology
dc.subject.classification	Neurology & Neurosurgery
dc.subject.mesh	Basal Ganglia Diseases
dc.subject.mesh	Brain
dc.subject.mesh	Humans
dc.subject.mesh	Iron
dc.subject.mesh	Parkinson Disease
dc.subject.mesh	Substantia Nigra
dc.subject.mesh	Basal Ganglia Diseases
dc.subject.mesh	Brain
dc.subject.mesh	Humans
dc.subject.mesh	Iron
dc.subject.mesh	Parkinson Disease
dc.subject.mesh	Substantia Nigra
dc.subject.mesh	Brain
dc.subject.mesh	Substantia Nigra
dc.subject.mesh	Humans
dc.subject.mesh	Basal Ganglia Diseases
dc.subject.mesh	Parkinson Disease
dc.subject.mesh	Iron
dc.title	A brief history of brain iron accumulation in Parkinson disease and related disorders.
dc.type	Journal Article
utslib.citation.volume	129
utslib.location.activity	Austria
utslib.for	1109 Neurosciences
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-22T02:41:22Z
pubs.issue	5-6
pubs.publication-status	Published
pubs.volume	129
utslib.citation.issue	5-6

Abstract:

Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for normal brain function, but abnormal brain iron accumulation has been associated with extrapyramidal disease for a century. Precisely why, how, and when iron is implicated in neuronal death remains the subject of investigation. In this article, we review the history of iron in movement disorders, from the first observations in the early twentieth century to recent efforts that view extrapyramidal iron as a novel therapeutic target and diagnostic indicator.

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http://hdl.handle.net/10453/163644