Psychological outcomes in advanced cancer patients after receiving genomic tumor profiling results.

Vatter, S; Schlub, TE; Napier, CE; Best, MC; Bartley, N; Juraskova, I; Meiser, B; Ballinger, ML; Biesecker, BB; Goldstein, D; Thomas, DM; Butow, P; Members of the PiGeOn Project,

Psychological outcomes in advanced cancer patients after receiving genomic tumor profiling results.

Vatter, S Schlub, TE Napier, CE Best, MC Bartley, N

Juraskova, I Meiser, B Ballinger, ML Biesecker, BB Goldstein, D Thomas, DM Butow, P Members of the PiGeOn Project,

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Publisher:: American Psychological Association
Publication Type:: Journal Article
Citation:: Health Psychology, 2022, 41, (6), pp. 396-408
Issue Date:: 2022-06

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Field	Value	Language
dc.contributor.author	Vatter, S
dc.contributor.author	Schlub, TE
dc.contributor.author	Napier, CE
dc.contributor.author	Best, MC
dc.contributor.author	Bartley, N https://orcid.org/0000-0001-9052-1616
dc.contributor.author	Juraskova, I
dc.contributor.author	Meiser, B
dc.contributor.author	Ballinger, ML
dc.contributor.author	Biesecker, BB
dc.contributor.author	Goldstein, D
dc.contributor.author	Thomas, DM
dc.contributor.author	Butow, P
dc.contributor.author	Members of the PiGeOn Project,
dc.date.accessioned	2022-11-24T04:27:05Z
dc.date.available	2022-11-24T04:27:05Z
dc.date.issued	2022-06
dc.identifier.citation	Health Psychology, 2022, 41, (6), pp. 396-408
dc.identifier.issn	0278-6133
dc.identifier.issn	1930-7810
dc.identifier.uri	http://hdl.handle.net/10453/163722
dc.description.abstract	BACKGROUND: Comprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted. However, receipt of nonactionable or ambiguous results could be an ongoing source of distress. We investigated patterns of hope, anxiety, depression, and CGP-specific anxiety in advanced cancer patients after receiving CGP results and 2-3 months later. METHOD: Participants were enrolled in a longitudinal psychosocial substudy, embedded in the Molecular Screening and Therapeutics Program, and had advanced solid cancers of any histological type with sufficient and accessible tissue for CGP. At T0 (before receiving CGP results), 1,431 participants completed sociodemographic, disease and psychosocial measures. At T1 (1-4 weeks after receiving CGP results) and T2 (2-3 months post-T1), 374 participants completed psychological outcome measures. Predictors of outcomes at T2 were identified using multinomial logistic regression. RESULTS: Approximately 75% of participants did not experience significant hopelessness or distress at T1 and T2. Hope decreased by T2, yet general anxiety and CGP-specific anxiety also decreased. Receiving actionable results did not impact psychological outcomes at T2. At T2, lower hope, and higher anxiety, depression and CGP-specific anxiety were associated with lower self-efficacy. Psychological and demographic factors (age, socioeconomic status, language, medical occupation, urban living, family history of cancer) independently predicted one or more psychological trajectories. Worse health status and perceived susceptibility to cancer progression predicted hope and anxiety trajectories. CONCLUSION: Further research on interventions to best support patients undergoing CGP with high anxiety, hopelessness, fear of cancer progression, and poorer health is urgently needed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
dc.format	Print
dc.language	eng
dc.publisher	American Psychological Association
dc.relation.ispartof	Health Psychology
dc.relation.isbasedon	10.1037/hea0001181
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences, 13 Education, 17 Psychology and Cognitive Sciences
dc.subject.classification	Public Health
dc.subject.mesh	Anxiety
dc.subject.mesh	Anxiety Disorders
dc.subject.mesh	Depression
dc.subject.mesh	Genomics
dc.subject.mesh	Health Status
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Anxiety
dc.subject.mesh	Anxiety Disorders
dc.subject.mesh	Depression
dc.subject.mesh	Genomics
dc.subject.mesh	Health Status
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Depression
dc.subject.mesh	Anxiety
dc.subject.mesh	Anxiety Disorders
dc.subject.mesh	Genomics
dc.subject.mesh	Health Status
dc.title	Psychological outcomes in advanced cancer patients after receiving genomic tumor profiling results.
dc.type	Journal Article
utslib.citation.volume	41
utslib.location.activity	United States
utslib.for	11 Medical and Health Sciences
utslib.for	13 Education
utslib.for	17 Psychology and Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-24T04:27:04Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	41
utslib.citation.issue	6

Abstract:

BACKGROUND: Comprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted. However, receipt of nonactionable or ambiguous results could be an ongoing source of distress. We investigated patterns of hope, anxiety, depression, and CGP-specific anxiety in advanced cancer patients after receiving CGP results and 2-3 months later. METHOD: Participants were enrolled in a longitudinal psychosocial substudy, embedded in the Molecular Screening and Therapeutics Program, and had advanced solid cancers of any histological type with sufficient and accessible tissue for CGP. At T0 (before receiving CGP results), 1,431 participants completed sociodemographic, disease and psychosocial measures. At T1 (1-4 weeks after receiving CGP results) and T2 (2-3 months post-T1), 374 participants completed psychological outcome measures. Predictors of outcomes at T2 were identified using multinomial logistic regression. RESULTS: Approximately 75% of participants did not experience significant hopelessness or distress at T1 and T2. Hope decreased by T2, yet general anxiety and CGP-specific anxiety also decreased. Receiving actionable results did not impact psychological outcomes at T2. At T2, lower hope, and higher anxiety, depression and CGP-specific anxiety were associated with lower self-efficacy. Psychological and demographic factors (age, socioeconomic status, language, medical occupation, urban living, family history of cancer) independently predicted one or more psychological trajectories. Worse health status and perceived susceptibility to cancer progression predicted hope and anxiety trajectories. CONCLUSION: Further research on interventions to best support patients undergoing CGP with high anxiety, hopelessness, fear of cancer progression, and poorer health is urgently needed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/163722