High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice.
- Publisher:
- AMER CHEMICAL SOC
- Publication Type:
- Journal Article
- Citation:
- Nano Lett, 2022, 22, (7), pp. 2793-2800
- Issue Date:
- 2022-04-13
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acs.nanolett.1c04909.pdf | 8.32 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Mi, C | |
dc.contributor.author | Guan, M | |
dc.contributor.author | Zhang, X | |
dc.contributor.author | Yang, L | |
dc.contributor.author | Wu, S | |
dc.contributor.author | Yang, Z | |
dc.contributor.author | Guo, Z | |
dc.contributor.author | Liao, J | |
dc.contributor.author |
Zhou, J https://orcid.org/0000-0002-0605-5745 |
|
dc.contributor.author | Lin, F | |
dc.contributor.author | Ma, E | |
dc.contributor.author |
Jin, D https://orcid.org/0000-0003-1046-2666 |
|
dc.contributor.author | Yuan, X | |
dc.date.accessioned | 2023-01-30T03:14:21Z | |
dc.date.available | 2023-01-30T03:14:21Z | |
dc.date.issued | 2022-04-13 | |
dc.identifier.citation | Nano Lett, 2022, 22, (7), pp. 2793-2800 | |
dc.identifier.issn | 1530-6984 | |
dc.identifier.issn | 1530-6992 | |
dc.identifier.uri | http://hdl.handle.net/10453/165578 | |
dc.description.abstract | Conventional biomedical imaging modalities, including endoscopy, X-rays, and magnetic resonance, are invasive and insufficient in spatial and temporal resolutions for gastrointestinal (GI) tract imaging to guide prognosis and therapy. Here we report a noninvasive method based on lanthanide-doped nanocrystals with ∼1530 nm fluorescence in the near-infrared-IIb window (NIR-IIb, 1500-1700 nm). The rational design of nanocrystals have led to an absolute quantum yield (QY) up to 48.6%. Further benefiting from the minimized scattering through the NIR-IIb window, we enhanced the spatial resolution to ∼1 mm in GI tract imaging, which is ∼3 times higher compared with the near-infrared-IIa (NIR-IIa, 1000-1500 nm) method. The approach also realized a high temporal resolution of 8 frames per second; thus the moment of mice intestinal peristalsis can be captured. Furthermore, with a light-sheet imaging system, we demonstrated a three-dimensional (3D) imaging on the GI tract. Moreover, we successfully translated these advances to diagnose inflammatory bowel disease. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | AMER CHEMICAL SOC | |
dc.relation.ispartof | Nano Lett | |
dc.relation.isbasedon | 10.1021/acs.nanolett.1c04909 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject.classification | Nanoscience & Nanotechnology | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Gastrointestinal Tract | |
dc.subject.mesh | Lanthanoid Series Elements | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Nanoparticles | |
dc.subject.mesh | Optical Imaging | |
dc.subject.mesh | Spectroscopy, Near-Infrared | |
dc.subject.mesh | Gastrointestinal Tract | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Lanthanoid Series Elements | |
dc.subject.mesh | Spectroscopy, Near-Infrared | |
dc.subject.mesh | Nanoparticles | |
dc.subject.mesh | Optical Imaging | |
dc.title | High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice. | |
dc.type | Journal Article | |
utslib.citation.volume | 22 | |
utslib.location.activity | United States | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2023-01-30T03:14:19Z | |
pubs.issue | 7 | |
pubs.publication-status | Published | |
pubs.volume | 22 | |
utslib.citation.issue | 7 |
Abstract:
Conventional biomedical imaging modalities, including endoscopy, X-rays, and magnetic resonance, are invasive and insufficient in spatial and temporal resolutions for gastrointestinal (GI) tract imaging to guide prognosis and therapy. Here we report a noninvasive method based on lanthanide-doped nanocrystals with ∼1530 nm fluorescence in the near-infrared-IIb window (NIR-IIb, 1500-1700 nm). The rational design of nanocrystals have led to an absolute quantum yield (QY) up to 48.6%. Further benefiting from the minimized scattering through the NIR-IIb window, we enhanced the spatial resolution to ∼1 mm in GI tract imaging, which is ∼3 times higher compared with the near-infrared-IIa (NIR-IIa, 1000-1500 nm) method. The approach also realized a high temporal resolution of 8 frames per second; thus the moment of mice intestinal peristalsis can be captured. Furthermore, with a light-sheet imaging system, we demonstrated a three-dimensional (3D) imaging on the GI tract. Moreover, we successfully translated these advances to diagnose inflammatory bowel disease.
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