Systemic Biomarkers and Unique Pathways in Different Phenotypes of Heart Failure with Preserved Ejection Fraction.
Chen, H
Tesic, M
Nikolic, VN
Pavlovic, M
Vucic, RM
Spasic, A
Jovanovic, H
Jovanovic, I
Town, SEL
Padula, MP
McClements, L
- Publisher:
- MDPI
- Publication Type:
- Journal Article
- Citation:
- Biomolecules, 2022, 12, (10), pp. 1419
- Issue Date:
- 2022-10-04
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, H | |
dc.contributor.author | Tesic, M | |
dc.contributor.author | Nikolic, VN | |
dc.contributor.author | Pavlovic, M | |
dc.contributor.author | Vucic, RM | |
dc.contributor.author | Spasic, A | |
dc.contributor.author | Jovanovic, H | |
dc.contributor.author | Jovanovic, I | |
dc.contributor.author | Town, SEL | |
dc.contributor.author | Padula, MP | |
dc.contributor.author |
McClements, L |
|
dc.date.accessioned | 2023-02-14T04:55:37Z | |
dc.date.available | 2022-09-29 | |
dc.date.available | 2023-02-14T04:55:37Z | |
dc.date.issued | 2022-10-04 | |
dc.identifier.citation | Biomolecules, 2022, 12, (10), pp. 1419 | |
dc.identifier.issn | 2218-273X | |
dc.identifier.issn | 2218-273X | |
dc.identifier.uri | http://hdl.handle.net/10453/166113 | |
dc.description.abstract | Heart failure with preserved ejection fraction (HFpEF) accounts for around 50% of all heart failure cases. It is a heterogeneous condition with poorly understood pathogenesis. Here, we aimed to identify unique pathogenic mechanisms in acute and chronic HFpEF and hypertrophic cardiomyopathy (HCM). We performed unbiased, comprehensive proteomic analyses of plasma samples from gender- and BMI-matched patients with acute HFpEF (n = 8), chronic HFpEF (n = 9) and HCM (n = 14) using liquid chromatography-mass spectrometry. Distinct molecular signatures were observed in different HFpEF forms. Clusters of biomarkers differentially abundant between HFpEF forms were predominantly associated with microvascular inflammation. New candidate protein markers were also identified, including leucine-rich alpha-2-glycoprotein 1 (LRG1), serum amyloid A1 (SAA1) and inter-alpha-trypsin inhibitor heavy chain 3 (ITIH3). Our study is the first to apply systematic, quantitative proteomic screening of plasma samples from patients with different subtypes of HFpEF and identify candidate biomarkers for improved management of acute and chronic HFpEF and HCM. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | MDPI | |
dc.relation.ispartof | Biomolecules | |
dc.relation.isbasedon | 10.3390/biom12101419 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0601 Biochemistry and Cell Biology | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Stroke Volume | |
dc.subject.mesh | Heart Failure | |
dc.subject.mesh | Proteomics | |
dc.subject.mesh | Leucine | |
dc.subject.mesh | Biomarkers | |
dc.subject.mesh | Phenotype | |
dc.subject.mesh | Glycoproteins | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Glycoproteins | |
dc.subject.mesh | Leucine | |
dc.subject.mesh | Stroke Volume | |
dc.subject.mesh | Proteomics | |
dc.subject.mesh | Phenotype | |
dc.subject.mesh | Heart Failure | |
dc.subject.mesh | Biomarkers | |
dc.title | Systemic Biomarkers and Unique Pathways in Different Phenotypes of Heart Failure with Preserved Ejection Fraction. | |
dc.type | Journal Article | |
utslib.citation.volume | 12 | |
utslib.location.activity | Switzerland | |
utslib.for | 0601 Biochemistry and Cell Biology | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
pubs.organisational-group | /University of Technology Sydney/Strength - CFI - Centre for Inflammation | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2023-02-14T04:55:32Z | |
pubs.issue | 10 | |
pubs.publication-status | Published online | |
pubs.volume | 12 | |
utslib.citation.issue | 10 |
Abstract:
Heart failure with preserved ejection fraction (HFpEF) accounts for around 50% of all heart failure cases. It is a heterogeneous condition with poorly understood pathogenesis. Here, we aimed to identify unique pathogenic mechanisms in acute and chronic HFpEF and hypertrophic cardiomyopathy (HCM). We performed unbiased, comprehensive proteomic analyses of plasma samples from gender- and BMI-matched patients with acute HFpEF (n = 8), chronic HFpEF (n = 9) and HCM (n = 14) using liquid chromatography-mass spectrometry. Distinct molecular signatures were observed in different HFpEF forms. Clusters of biomarkers differentially abundant between HFpEF forms were predominantly associated with microvascular inflammation. New candidate protein markers were also identified, including leucine-rich alpha-2-glycoprotein 1 (LRG1), serum amyloid A1 (SAA1) and inter-alpha-trypsin inhibitor heavy chain 3 (ITIH3). Our study is the first to apply systematic, quantitative proteomic screening of plasma samples from patients with different subtypes of HFpEF and identify candidate biomarkers for improved management of acute and chronic HFpEF and HCM.
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