Toxicity assessments and transcriptional effects of monofunctionalized Pt(II) complex under dark and light irradiation condition in Caenorhabditis elegans.

Chong, H; Fang, S; Yang, D; Tan, C; Wei, J; Chang, S-H; Fan, H; Yao, H; Qin, A; Shao, H; Zhang, Y; Leng, J; Su, D; Wang, C; Li, H

Toxicity assessments and transcriptional effects of monofunctionalized Pt(II) complex under dark and light irradiation condition in Caenorhabditis elegans.

Chong, H Fang, S Yang, D Tan, C Wei, J Chang, S-H Fan, H Yao, H Qin, A Shao, H Zhang, Y Leng, J Su, D

Wang, C Li, H

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Publisher:: ELSEVIER SCIENCE INC
Publication Type:: Journal Article
Citation:: J Inorg Biochem, 2022, 230, pp. 111720
Issue Date:: 2022-05

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Field	Value	Language
dc.contributor.author	Chong, H
dc.contributor.author	Fang, S
dc.contributor.author	Yang, D
dc.contributor.author	Tan, C
dc.contributor.author	Wei, J
dc.contributor.author	Chang, S-H
dc.contributor.author	Fan, H
dc.contributor.author	Yao, H
dc.contributor.author	Qin, A
dc.contributor.author	Shao, H
dc.contributor.author	Zhang, Y
dc.contributor.author	Leng, J
dc.contributor.author	Su, D https://orcid.org/0000-0002-3972-8205
dc.contributor.author	Wang, C
dc.contributor.author	Li, H
dc.date.accessioned	2023-02-22T01:34:47Z
dc.date.available	2022-01-04
dc.date.available	2023-02-22T01:34:47Z
dc.date.issued	2022-05
dc.identifier.citation	J Inorg Biochem, 2022, 230, pp. 111720
dc.identifier.issn	0162-0134
dc.identifier.issn	1873-3344
dc.identifier.uri	http://hdl.handle.net/10453/166299
dc.description.abstract	In vivo toxicity of aromatic ring (BODIPY, 1,3,5,7,8-pentamethyl dipyrrin borondifluoride) attached monofunctional Pt(II) complexes mCBP {[cis-Pt(NH3)2Cl] 8-(para-pyridine-methylene),1,3,5,7-tetramethyl dipyrrin borondifluoride}+ Nitrate- and dCBP {[cis-Pt(NH3)2Cl]28-(1,3-pyrimidine-5-methylene),1,3,5,7-tetramethyl dipyrrin borondifluoride}2+ diNitrate2- were tested in Caenorhabditis elegans (C. elegans). dCBP showed promising reactive oxygen ROS (reactive oxygen species) generating capability. This complex resulted reduction of lifespan, body length and egg laying rate under dark and light irradiation in both N2 (wild-type, cisplatin resistant) and ok938 (asna-1, cisplatin sensitive) C. elegans. Expressional change of several key cancer related pathway (JNK (c-Jun N-terminal kinase) and Wnt/β-catenin (Wingless/Integrated/β-catenin)) related genes (for instance, jnk-1, wrm-1 and gst-4) were confirmed by RNA sequencing experiments. These transcriptional alternations could explain physiological parameters change in nematode and partially revealed how both Pt(II) based complexes influence cancer related pathways. Furthermore, these associated genes exhibited the function of apoptosis, reduced chemoresistance of cancer cells and most of those expressional changes were linked to extended survival of cancer patients.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCIENCE INC
dc.relation.ispartof	J Inorg Biochem
dc.relation.isbasedon	10.1016/j.jinorgbio.2022.111720
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0302 Inorganic Chemistry, 0307 Theoretical and Computational Chemistry, 0399 Other Chemical Sciences
dc.subject.classification	Inorganic & Nuclear Chemistry
dc.subject.mesh	Animals
dc.subject.mesh	Caenorhabditis elegans
dc.subject.mesh	Caenorhabditis elegans Proteins
dc.subject.mesh	Cisplatin
dc.subject.mesh	Cytoskeletal Proteins
dc.subject.mesh	Humans
dc.subject.mesh	Platinum
dc.subject.mesh	Reactive Oxygen Species
dc.subject.mesh	beta Catenin
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Caenorhabditis elegans
dc.subject.mesh	Cisplatin
dc.subject.mesh	Platinum
dc.subject.mesh	Reactive Oxygen Species
dc.subject.mesh	Cytoskeletal Proteins
dc.subject.mesh	Caenorhabditis elegans Proteins
dc.subject.mesh	beta Catenin
dc.title	Toxicity assessments and transcriptional effects of monofunctionalized Pt(II) complex under dark and light irradiation condition in Caenorhabditis elegans.
dc.type	Journal Article
utslib.citation.volume	230
utslib.location.activity	United States
utslib.for	0302 Inorganic Chemistry
utslib.for	0307 Theoretical and Computational Chemistry
utslib.for	0399 Other Chemical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
utslib.copyright.status	closed_access	*
dc.date.updated	2023-02-22T01:34:46Z
pubs.publication-status	Published
pubs.volume	230

Abstract:

In vivo toxicity of aromatic ring (BODIPY, 1,3,5,7,8-pentamethyl dipyrrin borondifluoride) attached monofunctional Pt(II) complexes mCBP {[cis-Pt(NH3)2Cl] 8-(para-pyridine-methylene),1,3,5,7-tetramethyl dipyrrin borondifluoride}+ Nitrate- and dCBP {[cis-Pt(NH3)2Cl]28-(1,3-pyrimidine-5-methylene),1,3,5,7-tetramethyl dipyrrin borondifluoride}2+ diNitrate2- were tested in Caenorhabditis elegans (C. elegans). dCBP showed promising reactive oxygen ROS (reactive oxygen species) generating capability. This complex resulted reduction of lifespan, body length and egg laying rate under dark and light irradiation in both N2 (wild-type, cisplatin resistant) and ok938 (asna-1, cisplatin sensitive) C. elegans. Expressional change of several key cancer related pathway (JNK (c-Jun N-terminal kinase) and Wnt/β-catenin (Wingless/Integrated/β-catenin)) related genes (for instance, jnk-1, wrm-1 and gst-4) were confirmed by RNA sequencing experiments. These transcriptional alternations could explain physiological parameters change in nematode and partially revealed how both Pt(II) based complexes influence cancer related pathways. Furthermore, these associated genes exhibited the function of apoptosis, reduced chemoresistance of cancer cells and most of those expressional changes were linked to extended survival of cancer patients.

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http://hdl.handle.net/10453/166299