Mitochondria Transfer in Brain Injury and Disease.

Fairley, LH; Grimm, A; Eckert, A

Mitochondria Transfer in Brain Injury and Disease.

Fairley, LH Grimm, A Eckert, A

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Cells, 2022, 11, (22), pp. 3603
Issue Date:: 2022-11-14

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Field	Value	Language
dc.contributor.author	Fairley, LH
dc.contributor.author	Grimm, A
dc.contributor.author	Eckert, A
dc.date.accessioned	2023-02-28T03:21:01Z
dc.date.available	2022-11-12
dc.date.available	2023-02-28T03:21:01Z
dc.date.issued	2022-11-14
dc.identifier.citation	Cells, 2022, 11, (22), pp. 3603
dc.identifier.issn	2073-4409
dc.identifier.issn	2073-4409
dc.identifier.uri	http://hdl.handle.net/10453/166506
dc.description.abstract	Intercellular mitochondria transfer is a novel form of cell signalling in which whole mitochondria are transferred between cells in order to enhance cellular functions or aid in the degradation of dysfunctional mitochondria. Recent studies have observed intercellular mitochondria transfer between glia and neurons in the brain, and mitochondrial transfer has emerged as a key neuroprotective mechanism in a range of neurological conditions. In particular, artificial mitochondria transfer has sparked widespread interest as a potential therapeutic strategy for brain disorders. In this review, we discuss the mechanisms and effects of intercellular mitochondria transfer in the brain. The role of mitochondrial transfer in neurological conditions, including neurodegenerative disease, brain injury, and neurodevelopmental disorders, is discussed as well as therapeutic strategies targeting mitochondria transfer in the brain.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Cells
dc.relation.isbasedon	10.3390/cells11223603
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Humans
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Mitochondria
dc.subject.mesh	Brain Injuries
dc.subject.mesh	Brain
dc.subject.mesh	Neurons
dc.subject.mesh	Brain
dc.subject.mesh	Neurons
dc.subject.mesh	Mitochondria
dc.subject.mesh	Humans
dc.subject.mesh	Brain Injuries
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Humans
dc.subject.mesh	Neurodegenerative Diseases
dc.subject.mesh	Mitochondria
dc.subject.mesh	Brain Injuries
dc.subject.mesh	Brain
dc.subject.mesh	Neurons
dc.title	Mitochondria Transfer in Brain Injury and Disease.
dc.type	Journal Article
utslib.citation.volume	11
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	open_access	*
dc.date.updated	2023-02-28T03:20:56Z
pubs.issue	22
pubs.publication-status	Published online
pubs.volume	11
utslib.citation.issue	22

Abstract:

Intercellular mitochondria transfer is a novel form of cell signalling in which whole mitochondria are transferred between cells in order to enhance cellular functions or aid in the degradation of dysfunctional mitochondria. Recent studies have observed intercellular mitochondria transfer between glia and neurons in the brain, and mitochondrial transfer has emerged as a key neuroprotective mechanism in a range of neurological conditions. In particular, artificial mitochondria transfer has sparked widespread interest as a potential therapeutic strategy for brain disorders. In this review, we discuss the mechanisms and effects of intercellular mitochondria transfer in the brain. The role of mitochondrial transfer in neurological conditions, including neurodegenerative disease, brain injury, and neurodevelopmental disorders, is discussed as well as therapeutic strategies targeting mitochondria transfer in the brain.

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http://hdl.handle.net/10453/166506