Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements.
- Publisher:
- WILEY
- Publication Type:
- Journal Article
- Citation:
- J Biomed Mater Res B Appl Biomater, 2022, 110, (10), pp. 2276-2289
- Issue Date:
- 2022-10
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Stratton-Powell, AA | |
dc.contributor.author | Williams, S | |
dc.contributor.author | Tipper, JL | |
dc.contributor.author | Redmond, AC | |
dc.contributor.author | Brockett, CL | |
dc.date.accessioned | 2023-03-22T00:22:43Z | |
dc.date.available | 2022-04-18 | |
dc.date.available | 2023-03-22T00:22:43Z | |
dc.date.issued | 2022-10 | |
dc.identifier.citation | J Biomed Mater Res B Appl Biomater, 2022, 110, (10), pp. 2276-2289 | |
dc.identifier.issn | 1552-4973 | |
dc.identifier.issn | 1552-4981 | |
dc.identifier.uri | http://hdl.handle.net/10453/168018 | |
dc.description.abstract | Submicron-sized wear particles are generally accepted as a potential cause of aseptic loosening when produced in sufficient volumes. With the accelerating use of increasingly wear-resistant biomaterials, identifying such particles and evaluating their biological response is becoming more challenging. Highly sensitive wear particle isolation methods have been developed but these methods cannot isolate the complete spectrum of particle types present in individual tissue samples. Two established techniques were modified to create one novel method to isolate both high- and low-density materials from periprosthetic tissue samples. Ten total hip replacement and eight total knee replacement tissue samples were processed. All particle types were characterized using high resolution scanning electron microscopy. UHMWPE and a range of high-density materials were isolated from all tissue samples, including: polymethylmethacrylate, zirconium dioxide, titanium alloy, cobalt chromium alloy and stainless steel. This feasibility study demonstrates the coexistence of mixed particle types in periprosthetic tissues and provides researchers with high-resolution images of clinically relevant wear particles that could be used as a reference for future in vitro biological response studies. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | WILEY | |
dc.relation.ispartof | J Biomed Mater Res B Appl Biomater | |
dc.relation.isbasedon | 10.1002/jbm.b.35076 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0903 Biomedical Engineering, 0912 Materials Engineering | |
dc.subject.classification | Biomedical Engineering | |
dc.subject.mesh | Alloys | |
dc.subject.mesh | Arthroplasty, Replacement, Hip | |
dc.subject.mesh | Arthroplasty, Replacement, Knee | |
dc.subject.mesh | Hip Prosthesis | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Particle Size | |
dc.subject.mesh | Polyethylenes | |
dc.subject.mesh | Prosthesis Failure | |
dc.subject.mesh | Titanium | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Prosthesis Failure | |
dc.subject.mesh | Titanium | |
dc.subject.mesh | Alloys | |
dc.subject.mesh | Polyethylenes | |
dc.subject.mesh | Arthroplasty, Replacement, Hip | |
dc.subject.mesh | Arthroplasty, Replacement, Knee | |
dc.subject.mesh | Hip Prosthesis | |
dc.subject.mesh | Particle Size | |
dc.subject.mesh | Alloys | |
dc.subject.mesh | Arthroplasty, Replacement, Hip | |
dc.subject.mesh | Arthroplasty, Replacement, Knee | |
dc.subject.mesh | Hip Prosthesis | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Particle Size | |
dc.subject.mesh | Polyethylenes | |
dc.subject.mesh | Prosthesis Failure | |
dc.subject.mesh | Titanium | |
dc.title | Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements. | |
dc.type | Journal Article | |
utslib.citation.volume | 110 | |
utslib.location.activity | United States | |
utslib.for | 0903 Biomedical Engineering | |
utslib.for | 0912 Materials Engineering | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2023-03-22T00:22:32Z | |
pubs.issue | 10 | |
pubs.publication-status | Published | |
pubs.volume | 110 | |
utslib.citation.issue | 10 |
Abstract:
Submicron-sized wear particles are generally accepted as a potential cause of aseptic loosening when produced in sufficient volumes. With the accelerating use of increasingly wear-resistant biomaterials, identifying such particles and evaluating their biological response is becoming more challenging. Highly sensitive wear particle isolation methods have been developed but these methods cannot isolate the complete spectrum of particle types present in individual tissue samples. Two established techniques were modified to create one novel method to isolate both high- and low-density materials from periprosthetic tissue samples. Ten total hip replacement and eight total knee replacement tissue samples were processed. All particle types were characterized using high resolution scanning electron microscopy. UHMWPE and a range of high-density materials were isolated from all tissue samples, including: polymethylmethacrylate, zirconium dioxide, titanium alloy, cobalt chromium alloy and stainless steel. This feasibility study demonstrates the coexistence of mixed particle types in periprosthetic tissues and provides researchers with high-resolution images of clinically relevant wear particles that could be used as a reference for future in vitro biological response studies.
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