Flow-Based Synthesis of Gold-Coated Magnetic Nanoparticles for Magnetoplasmonic Sensing Applications

Publisher:
Wiley
Publication Type:
Journal Article
Citation:
Particle and Particle Systems Characterization, 2022, 39, (8), pp. 2200051
Issue Date:
2022-08-01
Full metadata record
Gold-coated magnetic nanoparticles are key materials for the fast separation and ultrasensitive detection of analytes in magnetoplasmonic sensors. However, the synthesis of gold-coated magnetic nanoparticles typically requires small-scale, colloidal methods over hours or days and often results in incomplete shells with variable optical properties. A robust, rapid, and scalable synthesis method is still needed to reliably form a complete gold nanoshell around magnetic nanoparticles. Herein, a new methodology for the synthesis of gold-coated magnetic nanoparticles via a flow-based manufacturing system that can easily be scaled up is presented. The developed method first produces gold-seeded silica coated magnetic nanoparticles and then a complete, tunable gold shell with relatively uniform size and shape. The flow-based method can be performed in a total time of less than 2 min, enabling rapid and complete gold coating. The particles show both excellent magnetic and plasmonic properties, which facilitates application as biosensing agents in dark-field microscopy and surface-enhanced Raman scattering.
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