Association between miRNAs expression and multiple sclerosis pathogenesis: A novel therapeutic approach

Beyrampour-Basmenj, H; Rahmati, M; Moghamddam, MP; Kalan, ME; Alivand, M; Aliyari-Serej, Z; Nastarin, P; Omrani, M; Khodakarimi, S; Ebrahimi-Kalan, A

Association between miRNAs expression and multiple sclerosis pathogenesis: A novel therapeutic approach

Beyrampour-Basmenj, H Rahmati, M Moghamddam, MP Kalan, ME Alivand, M Aliyari-Serej, Z Nastarin, P Omrani, M Khodakarimi, S Ebrahimi-Kalan, A

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Gene Reports, 2022, 26, pp. 101457-101457
Issue Date:: 2022-03

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Field	Value	Language
dc.contributor.author	Beyrampour-Basmenj, H
dc.contributor.author	Rahmati, M
dc.contributor.author	Moghamddam, MP
dc.contributor.author	Kalan, ME
dc.contributor.author	Alivand, M
dc.contributor.author	Aliyari-Serej, Z
dc.contributor.author	Nastarin, P
dc.contributor.author	Omrani, M
dc.contributor.author	Khodakarimi, S
dc.contributor.author	Ebrahimi-Kalan, A
dc.date.accessioned	2023-04-04T20:42:58Z
dc.date.available	2023-04-04T20:42:58Z
dc.date.issued	2022-03
dc.identifier.citation	Gene Reports, 2022, 26, pp. 101457-101457
dc.identifier.issn	2452-0144
dc.identifier.uri	http://hdl.handle.net/10453/169116
dc.description.abstract	Multiple Sclerosis (MS) is an immune-mediated neurodegenerative disorder that can affect both the nervous and immune systems of the body. The determination of diagnostic, prognostic, and treatment-associated biomarkers has attracted the attention of many researchers. MiRNAs, as non-coding RNAs, play a pivotal role in modifying the autoimmune process of MS in both immune and nerve cells. They have great potential to be developed as diagnostic and therapeutic biomarkers. This review comprehensively summarizes the variably expressed miRNAs in neural cells, and MS patients' biofluids. It has been proven that some dysregulated miRNAs are related to the pathogenesis of the disease, and these miRNAs could be utilized as biomarkers in determining various states of MS and defining effective therapeutic strategies.
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Gene Reports
dc.relation.isbasedon	10.1016/j.genrep.2021.101457
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Association between miRNAs expression and multiple sclerosis pathogenesis: A novel therapeutic approach
dc.type	Journal Article
utslib.citation.volume	26
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2023-04-04T20:42:57Z
pubs.publication-status	Published
pubs.volume	26

Abstract:

Multiple Sclerosis (MS) is an immune-mediated neurodegenerative disorder that can affect both the nervous and immune systems of the body. The determination of diagnostic, prognostic, and treatment-associated biomarkers has attracted the attention of many researchers. MiRNAs, as non-coding RNAs, play a pivotal role in modifying the autoimmune process of MS in both immune and nerve cells. They have great potential to be developed as diagnostic and therapeutic biomarkers. This review comprehensively summarizes the variably expressed miRNAs in neural cells, and MS patients' biofluids. It has been proven that some dysregulated miRNAs are related to the pathogenesis of the disease, and these miRNAs could be utilized as biomarkers in determining various states of MS and defining effective therapeutic strategies.

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http://hdl.handle.net/10453/169116