Complementary and alternative medicine in reducing radiation-induced skin toxicity.

Hu, JJ; Cui, T; Rodriguez-Gil, JL; Allen, GO; Li, J; Takita, C; Lally, BE

Complementary and alternative medicine in reducing radiation-induced skin toxicity.

Hu, JJ Cui, T Rodriguez-Gil, JL Allen, GO Li, J Takita, C Lally, BE

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Publication Type:: Journal Article
Citation:: Radiat Environ Biophys, 2014, 53 (3), pp. 621 - 626
Issue Date:: 2014-08

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Field	Value	Language
dc.contributor.author	Hu, JJ	en_US
dc.contributor.author	Cui, T	en_US
dc.contributor.author	Rodriguez-Gil, JL	en_US
dc.contributor.author	Allen, GO	en_US
dc.contributor.author	Li, J	en_US
dc.contributor.author	Takita, C	en_US
dc.contributor.author	Lally, BE	en_US
dc.date.available	2014-04-06	en_US
dc.date.issued	2014-08	en_US
dc.identifier.citation	Radiat Environ Biophys, 2014, 53 (3), pp. 621 - 626	en_US
dc.identifier.uri	http://hdl.handle.net/10453/16987
dc.description.abstract	Radiation therapy-induced acute and late effects, particularly skin toxicities, have significant impact on cancer patients' quality of life and long-term survival. To date, no effective topical agents have been routinely used in the clinical setting to prevent skin toxicity. Using SKH-hr1 hairless mice, we investigated two complementary and alternative medicine in their effects on inflammation and ionizing radiation (IR)-induced skin toxicity: Calendula officinalis (CO) and Ching Wan Hung (CWH). They were applied immediately following each IR dosing of 10 Gy/day for 4 days. Skin toxicity and inflammatory factors were evaluated at multiple time points up to 15 days post-radiation. Serum interleukin (IL)-1α, monocyte chemotactic protein-1 (MCP1), keratinocyte-derived chemokine (KC), and granulocyte colony-stimulating factor (G-CSF) were significantly induced by radiation. Both CO and CWH significantly inhibited IR-induced MCP1 (p < 0.01), KC (p < 0.05), and G-CSF (p < 0.001). IR-induced erythema and blood vessel dilation were significantly reduced by CWH (p < 0.001) but not by CO at day 10 post-IR. Both agents inhibited IR-induced IL-1α (p < 0.01), MCP1 (p < 0.05), and vascular endothelial growth factor (p < 0.05). There were continuous inhibitory effects of CWH on IR-induced skin toxicities and inflammation. In contrast, CO treatment resulted in skin reactions compared to IR alone. Our results suggest that both CO and CWH reduce IR-induced inflammation and CWH reduced IR-induced erythema. In summary, CWH showed promising effects in reducing IR-related inflammation and skin toxicities, and future proof-of-principal testing in humans will be critical in evaluating its potential application in preventing IR-induced skin toxicities.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Radiat Environ Biophys	en_US
dc.relation.isbasedon	10.1007/s00411-014-0540-y	en_US
dc.subject.classification	Geriatrics	en_US
dc.subject.mesh	Skin	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Calendula	en_US
dc.subject.mesh	Neoplasms	en_US
dc.subject.mesh	Dermatitis	en_US
dc.subject.mesh	Radiation Injuries, Experimental	en_US
dc.subject.mesh	Drugs, Chinese Herbal	en_US
dc.subject.mesh	Angiogenesis Inducing Agents	en_US
dc.subject.mesh	Complementary Therapies	en_US
dc.subject.mesh	Radiotherapy	en_US
dc.subject.mesh	Female	en_US
dc.title	Complementary and alternative medicine in reducing radiation-induced skin toxicity.	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	53	en_US
utslib.location.activity	Germany	en_US
utslib.for	1104 Complementary and Alternative Medicine	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	open_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	53	en_US

Abstract:

Radiation therapy-induced acute and late effects, particularly skin toxicities, have significant impact on cancer patients' quality of life and long-term survival. To date, no effective topical agents have been routinely used in the clinical setting to prevent skin toxicity. Using SKH-hr1 hairless mice, we investigated two complementary and alternative medicine in their effects on inflammation and ionizing radiation (IR)-induced skin toxicity: Calendula officinalis (CO) and Ching Wan Hung (CWH). They were applied immediately following each IR dosing of 10 Gy/day for 4 days. Skin toxicity and inflammatory factors were evaluated at multiple time points up to 15 days post-radiation. Serum interleukin (IL)-1α, monocyte chemotactic protein-1 (MCP1), keratinocyte-derived chemokine (KC), and granulocyte colony-stimulating factor (G-CSF) were significantly induced by radiation. Both CO and CWH significantly inhibited IR-induced MCP1 (p < 0.01), KC (p < 0.05), and G-CSF (p < 0.001). IR-induced erythema and blood vessel dilation were significantly reduced by CWH (p < 0.001) but not by CO at day 10 post-IR. Both agents inhibited IR-induced IL-1α (p < 0.01), MCP1 (p < 0.05), and vascular endothelial growth factor (p < 0.05). There were continuous inhibitory effects of CWH on IR-induced skin toxicities and inflammation. In contrast, CO treatment resulted in skin reactions compared to IR alone. Our results suggest that both CO and CWH reduce IR-induced inflammation and CWH reduced IR-induced erythema. In summary, CWH showed promising effects in reducing IR-related inflammation and skin toxicities, and future proof-of-principal testing in humans will be critical in evaluating its potential application in preventing IR-induced skin toxicities.

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http://hdl.handle.net/10453/16987