| Field |
Value |
Language |
|
dc.contributor.author |
Feng, M |
|
|
dc.contributor.author |
Bai, X |
|
|
dc.contributor.author |
Thorpe, AE |
|
|
dc.contributor.author |
Nguyen, LT |
|
|
dc.contributor.author |
Wang, M |
|
|
dc.contributor.author |
Oliver, BG |
|
|
dc.contributor.author |
Chou, ASY |
|
|
dc.contributor.author |
Pollock, CA |
|
|
dc.contributor.author |
Saad, S |
|
|
dc.contributor.author |
Chen, H
https://orcid.org/0000-0001-6883-3752
|
|
|
dc.date.accessioned |
2023-07-18T07:07:30Z |
|
|
dc.date.available |
2023-07-18T07:07:30Z |
|
|
dc.identifier.citation |
Nutrients, 15, (14), pp. 3140-3140 |
|
|
dc.identifier.issn |
2072-6643 |
|
|
dc.identifier.uri |
http://hdl.handle.net/10453/171561
|
|
|
dc.description.abstract |
<jats:p>High-fat diet (HFD) consumption and tobacco smoking are risk factors for chronic kidney disease. E-cigarettes have gained significant popularity among younger populations worldwide, especially among overweight individuals. It is unclear whether vaping interacts with HFD consumption to impact renal health. In this study, Balb/c mice (male, 7 weeks old) were fed a pellet HFD (43% fat, 20 kJ/g) for 16 weeks when exposed to nicotine or nicotine-free e-vapour from weeks 11 to 16. While HFD alone increased collagen Ia and IV depositions, it did not cause significant oxidative stress and inflammatory responses in the kidney itself. On the other hand, e-vapour exposure alone increased oxidative stress and damaged DNA and mitochondrial oxidative phosphorylation complexes without significant impact on fibrotic markers. However, the combination of nicotine e-vapour and HFD increased inflammatory responses, oxidative stress-induced DNA injury, and pro-fibrotic markers, suggesting accelerated development of renal pathology. Nicotine-free e-vapour exposure and HFD consumption suppressed the production of mitochondrial OXPHOS complexes and extracellular matrix protein deposition, which may cause structural instability that can interrupt normal kidney function in the future. In conclusion, our study demonstrated that a HFD combined with e-cigarette vapour exposure, especially when containing nicotine, can increase susceptibility to kidney disease.</jats:p> |
|
|
dc.language |
en |
|
|
dc.publisher |
MDPI AG |
|
|
dc.relation |
http://purl.org/au-research/grants/nhmrc/APP1158186
|
|
|
dc.relation |
http://purl.org/au-research/grants/nhmrc/GNT1158186
|
|
|
dc.relation.ispartof |
Nutrients |
|
|
dc.relation.isbasedon |
10.3390/nu15143140 |
|
|
dc.rights |
info:eu-repo/semantics/openAccess |
|
|
dc.subject |
0908 Food Sciences, 1111 Nutrition and Dietetics |
|
|
dc.subject.classification |
3202 Clinical sciences |
|
|
dc.subject.classification |
3210 Nutrition and dietetics |
|
|
dc.subject.classification |
4206 Public health |
|
|
dc.title |
Effect of E-Vaping on Kidney Health in Mice Consuming a High-Fat Diet |
|
|
dc.type |
Journal Article |
|
|
utslib.citation.volume |
15 |
|
|
utslib.for |
0908 Food Sciences |
|
|
utslib.for |
1111 Nutrition and Dietetics |
|
|
pubs.organisational-group |
/University of Technology Sydney |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science |
|
|
pubs.organisational-group |
/University of Technology Sydney/Strength - CHT - Health Technologies |
|
|
pubs.organisational-group |
/University of Technology Sydney/Faculty of Science/School of Life Sciences |
|
|
pubs.organisational-group |
/University of Technology Sydney/Centre for Health Technologies (CHT) |
|
|
utslib.copyright.status |
open_access |
* |
|
dc.date.updated |
2023-07-18T07:07:28Z |
|
|
pubs.issue |
14 |
|
|
pubs.publication-status |
Published online |
|
|
pubs.volume |
15 |
|
|
utslib.citation.issue |
14 |
|
