COVID-19-induced autoimmune thyroiditis: Exploring molecular mechanisms.

Mohammadi, B; Dua, K; Saghafi, M; Singh, SK; Heydarifard, Z; Zandi, M

COVID-19-induced autoimmune thyroiditis: Exploring molecular mechanisms.

Mohammadi, B Dua, K

Saghafi, M Singh, SK Heydarifard, Z Zandi, M

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: J Med Virol, 2023, 95, (8), pp. e29001
Issue Date:: 2023-08

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Field	Value	Language
dc.contributor.author	Mohammadi, B
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Saghafi, M
dc.contributor.author	Singh, SK
dc.contributor.author	Heydarifard, Z
dc.contributor.author	Zandi, M
dc.date.accessioned	2023-08-03T06:31:00Z
dc.date.available	2023-07-19
dc.date.available	2023-08-03T06:31:00Z
dc.date.issued	2023-08
dc.identifier.citation	J Med Virol, 2023, 95, (8), pp. e29001
dc.identifier.issn	0146-6615
dc.identifier.issn	1096-9071
dc.identifier.uri	http://hdl.handle.net/10453/171712
dc.description.abstract	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) damages multiple organs, including the thyroid, by direct invasion and cell entry via angiotensin-converting enzyme 2 or indirectly by promoting excessive inflammation in the body. The immune system is a critical factor in antiviral immunity and disease progression. In the context of SARS-CoV-2 infection, the immune system may become overly activated, resulting in a shift from regulatory to effector responses, which may subsequently promote the development and progression of autoimmune diseases. The incidence of autoimmune thyroid diseases, such as subacute thyroiditis, Graves' disease, and Hashimoto's thyroiditis, increases in individuals with COVID-19 infection. This phenomenon may be attributed to aberrant responses of T-cell subtypes, the presence of autoantibodies, impaired regulatory cell function, and excessive production of inflammatory cytokines, namely interleukin (IL)-6, IL-1β, interferon-γ, and tumor necrosis factor-α. Therefore, insights into the immune responses involved in the development of autoimmune thyroid disease according to COVID-19 can help identify potential therapeutic approaches and guide the development of effective interventions to alleviate patients' symptoms.
dc.format	Print
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	J Med Virol
dc.relation.isbasedon	10.1002/jmv.29001
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0605 Microbiology, 1108 Medical Microbiology
dc.subject.classification	Virology
dc.subject.classification	3107 Microbiology
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3207 Medical microbiology
dc.subject.mesh	Humans
dc.subject.mesh	Thyroiditis, Autoimmune
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Thyroiditis
dc.subject.mesh	Graves Disease
dc.subject.mesh	Humans
dc.subject.mesh	Thyroiditis
dc.subject.mesh	Thyroiditis, Autoimmune
dc.subject.mesh	Graves Disease
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.title	COVID-19-induced autoimmune thyroiditis: Exploring molecular mechanisms.
dc.type	Journal Article
utslib.citation.volume	95
utslib.location.activity	United States
utslib.for	0605 Microbiology
utslib.for	1108 Medical Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2023-08-03T06:30:59Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	95
utslib.citation.issue	8

Abstract:

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) damages multiple organs, including the thyroid, by direct invasion and cell entry via angiotensin-converting enzyme 2 or indirectly by promoting excessive inflammation in the body. The immune system is a critical factor in antiviral immunity and disease progression. In the context of SARS-CoV-2 infection, the immune system may become overly activated, resulting in a shift from regulatory to effector responses, which may subsequently promote the development and progression of autoimmune diseases. The incidence of autoimmune thyroid diseases, such as subacute thyroiditis, Graves' disease, and Hashimoto's thyroiditis, increases in individuals with COVID-19 infection. This phenomenon may be attributed to aberrant responses of T-cell subtypes, the presence of autoantibodies, impaired regulatory cell function, and excessive production of inflammatory cytokines, namely interleukin (IL)-6, IL-1β, interferon-γ, and tumor necrosis factor-α. Therefore, insights into the immune responses involved in the development of autoimmune thyroid disease according to COVID-19 can help identify potential therapeutic approaches and guide the development of effective interventions to alleviate patients' symptoms.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/171712