Precision Medicine Is Changing the Roles of Healthcare Professionals, Scientists, and Research Staff: Learnings from a Childhood Cancer Precision Medicine Trial.

Daly, R; Hetherington, K; Hazell, E; Wadling, BR; Tyrrell, V; Tucker, KM; Marshall, GM; Ziegler, DS; Lau, LMS; Trahair, TN; O'Brien, TA; Collins, K; Gifford, AJ; Haber, M; Pinese, M; Malkin, D; Cowley, MJ; Karpelowsky, J; Drew, D; Jacobs, C; Wakefield, CE

Precision Medicine Is Changing the Roles of Healthcare Professionals, Scientists, and Research Staff: Learnings from a Childhood Cancer Precision Medicine Trial.

Daly, R Hetherington, K Hazell, E Wadling, BR Tyrrell, V Tucker, KM Marshall, GM Ziegler, DS Lau, LMS Trahair, TN O'Brien, TA Collins, K Gifford, AJ Haber, M Pinese, M Malkin, D Cowley, MJ Karpelowsky, J Drew, D Jacobs, C

Wakefield, CE

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: J Pers Med, 2023, 13, (7), pp. 1033
Issue Date:: 2023-06-23

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Field	Value	Language
dc.contributor.author	Daly, R
dc.contributor.author	Hetherington, K
dc.contributor.author	Hazell, E
dc.contributor.author	Wadling, BR
dc.contributor.author	Tyrrell, V
dc.contributor.author	Tucker, KM
dc.contributor.author	Marshall, GM
dc.contributor.author	Ziegler, DS
dc.contributor.author	Lau, LMS
dc.contributor.author	Trahair, TN
dc.contributor.author	O'Brien, TA
dc.contributor.author	Collins, K
dc.contributor.author	Gifford, AJ
dc.contributor.author	Haber, M
dc.contributor.author	Pinese, M
dc.contributor.author	Malkin, D
dc.contributor.author	Cowley, MJ
dc.contributor.author	Karpelowsky, J
dc.contributor.author	Drew, D
dc.contributor.author	Jacobs, C https://orcid.org/0000-0002-9557-9080
dc.contributor.author	Wakefield, CE
dc.date.accessioned	2023-09-06T02:58:04Z
dc.date.available	2023-06-21
dc.date.available	2023-09-06T02:58:04Z
dc.date.issued	2023-06-23
dc.identifier.citation	J Pers Med, 2023, 13, (7), pp. 1033
dc.identifier.issn	2075-4426
dc.identifier.issn	2075-4426
dc.identifier.uri	http://hdl.handle.net/10453/171943
dc.description.abstract	Precision medicine programs aim to utilize novel technologies to identify personalized treatments for children with cancer. Delivering these programs requires interdisciplinary efforts, yet the many groups involved are understudied. This study explored the experiences of a broad range of professionals delivering Australia's first precision medicine trial for children with poor-prognosis cancer: the PRecISion Medicine for Children with Cancer (PRISM) national clinical trial of the Zero Childhood Cancer Program. We conducted semi-structured interviews with 85 PRISM professionals from eight professional groups, including oncologists, surgeons, clinical research associates, scientists, genetic professionals, pathologists, animal care technicians, and nurses. We analyzed interviews thematically. Professionals shared that precision medicine can add complexity to their role and result in less certain outcomes for families. Although many participants described experiencing a greater emotional impact from their work, most expressed very positive views about the impact of precision medicine on their profession and its future potential. Most reported navigating precision medicine without formal training. Each group described unique challenges involved in adapting to precision medicine in their profession. Addressing training gaps and meeting the specific needs of many professional groups involved in precision medicine will be essential to ensure the successful implementation of standard care.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	J Pers Med
dc.relation.isbasedon	10.3390/jpm13071033
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights	Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.subject.classification	3205 Medical biochemistry and metabolomics
dc.subject.classification	3206 Medical biotechnology
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.title	Precision Medicine Is Changing the Roles of Healthcare Professionals, Scientists, and Research Staff: Learnings from a Childhood Cancer Precision Medicine Trial.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.date.updated	2023-09-06T02:58:00Z
pubs.issue	7
pubs.publication-status	Published online
pubs.volume	13
utslib.citation.issue	7

Abstract:

Precision medicine programs aim to utilize novel technologies to identify personalized treatments for children with cancer. Delivering these programs requires interdisciplinary efforts, yet the many groups involved are understudied. This study explored the experiences of a broad range of professionals delivering Australia's first precision medicine trial for children with poor-prognosis cancer: the PRecISion Medicine for Children with Cancer (PRISM) national clinical trial of the Zero Childhood Cancer Program. We conducted semi-structured interviews with 85 PRISM professionals from eight professional groups, including oncologists, surgeons, clinical research associates, scientists, genetic professionals, pathologists, animal care technicians, and nurses. We analyzed interviews thematically. Professionals shared that precision medicine can add complexity to their role and result in less certain outcomes for families. Although many participants described experiencing a greater emotional impact from their work, most expressed very positive views about the impact of precision medicine on their profession and its future potential. Most reported navigating precision medicine without formal training. Each group described unique challenges involved in adapting to precision medicine in their profession. Addressing training gaps and meeting the specific needs of many professional groups involved in precision medicine will be essential to ensure the successful implementation of standard care.

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http://hdl.handle.net/10453/171943