Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms.

Mendes de Almeida, V; Engel, DF; Ricci, MF; Cruz, CS; Lopes, ÍS; Alves, DA; d' Auriol, M; Magalhães, J; Machado, EC; Rocha, VM; Carvalho, TG; Lacerda, LSB; Pimenta, JC; Aganetti, M; Zuccoli, GS; Smith, BJ; Carregari, VC; da Silva Rosa, E; Galvão, I; Dantas Cassali, G; Garcia, CC; Teixeira, MM; André, LC; Ribeiro, FM; Martins, FS; Saia, RS; Costa, VV; Martins-de-Souza, D; Hansbro, PM; Marques, JT; Aguiar, ERGR; Vieira, AT

Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms.

Mendes de Almeida, V Engel, DF Ricci, MF Cruz, CS Lopes, ÍS Alves, DA d' Auriol, M Magalhães, J Machado, EC Rocha, VM Carvalho, TG Lacerda, LSB Pimenta, JC Aganetti, M Zuccoli, GS Smith, BJ Carregari, VC da Silva Rosa, E Galvão, I Dantas Cassali, G Garcia, CC Teixeira, MM André, LC Ribeiro, FM Martins, FS Saia, RS Costa, VV Martins-de-Souza, D Hansbro, PM Marques, JT Aguiar, ERGR Vieira, AT

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Publisher:: Taylor & Francis
Publication Type:: Journal Article
Citation:: Gut Microbes, 2023, 15, (2), pp. 2249146
Issue Date:: 2023-12

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Field	Value	Language
dc.contributor.author	Mendes de Almeida, V
dc.contributor.author	Engel, DF
dc.contributor.author	Ricci, MF
dc.contributor.author	Cruz, CS
dc.contributor.author	Lopes, ÍS
dc.contributor.author	Alves, DA
dc.contributor.author	d' Auriol, M
dc.contributor.author	Magalhães, J
dc.contributor.author	Machado, EC
dc.contributor.author	Rocha, VM
dc.contributor.author	Carvalho, TG
dc.contributor.author	Lacerda, LSB
dc.contributor.author	Pimenta, JC
dc.contributor.author	Aganetti, M
dc.contributor.author	Zuccoli, GS
dc.contributor.author	Smith, BJ
dc.contributor.author	Carregari, VC
dc.contributor.author	da Silva Rosa, E
dc.contributor.author	Galvão, I
dc.contributor.author	Dantas Cassali, G
dc.contributor.author	Garcia, CC
dc.contributor.author	Teixeira, MM
dc.contributor.author	André, LC
dc.contributor.author	Ribeiro, FM
dc.contributor.author	Martins, FS
dc.contributor.author	Saia, RS
dc.contributor.author	Costa, VV
dc.contributor.author	Martins-de-Souza, D
dc.contributor.author	Hansbro, PM
dc.contributor.author	Marques, JT
dc.contributor.author	Aguiar, ERGR
dc.contributor.author	Vieira, AT
dc.date.accessioned	2023-09-20T00:25:49Z
dc.date.available	2023-09-20T00:25:49Z
dc.date.issued	2023-12
dc.identifier.citation	Gut Microbes, 2023, 15, (2), pp. 2249146
dc.identifier.issn	1949-0976
dc.identifier.issn	1949-0984
dc.identifier.uri	http://hdl.handle.net/10453/172205
dc.description.abstract	Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to disease severity in patients with COVID-19. Here, we report that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces. Fecal transplantation from post-COVID subjects to germ-free mice led to lung inflammation and worse outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection on the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.
dc.format	Print
dc.language	eng
dc.publisher	Taylor & Francis
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation	http://purl.org/au-research/grants/nhmrc/2010287
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1175134
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT2010287
dc.relation.ispartof	Gut Microbes
dc.relation.isbasedon	10.1080/19490976.2023.2249146
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0605 Microbiology
dc.subject.classification	3107 Microbiology
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	COVID-19
dc.subject.mesh	Gastrointestinal Microbiome
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Disease Progression
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Disease Progression
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Gastrointestinal Microbiome
dc.subject.mesh	COVID-19
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	COVID-19
dc.subject.mesh	Gastrointestinal Microbiome
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Disease Progression
dc.title	Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	United States
utslib.for	0605 Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	open_access	*
dc.date.updated	2023-09-20T00:25:38Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	15
utslib.citation.issue	2

Abstract:

Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to disease severity in patients with COVID-19. Here, we report that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces. Fecal transplantation from post-COVID subjects to germ-free mice led to lung inflammation and worse outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection on the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/172205