Risk of organism acquisition from prior room occupants: An updated systematic review.

Mitchell, BG; McDonagh, J; Dancer, SJ; Ford, S; Sim, J; Thottiyil Sultanmuhammed Abdul Khadar, B; Russo, PL; Maillard, J-Y; Rawson, H; Browne, K; Kiernan, M

Risk of organism acquisition from prior room occupants: An updated systematic review.

Mitchell, BG McDonagh, J Dancer, SJ Ford, S Sim, J

Thottiyil Sultanmuhammed Abdul Khadar, B Russo, PL Maillard, J-Y Rawson, H Browne, K Kiernan, M

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Infect Dis Health, 2023, 28, (4), pp. 290-297
Issue Date:: 2023-11

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Field	Value	Language
dc.contributor.author	Mitchell, BG
dc.contributor.author	McDonagh, J
dc.contributor.author	Dancer, SJ
dc.contributor.author	Ford, S
dc.contributor.author	Sim, J https://orcid.org/0000-0001-6863-0541
dc.contributor.author	Thottiyil Sultanmuhammed Abdul Khadar, B
dc.contributor.author	Russo, PL
dc.contributor.author	Maillard, J-Y
dc.contributor.author	Rawson, H
dc.contributor.author	Browne, K
dc.contributor.author	Kiernan, M
dc.date.accessioned	2023-11-14T04:20:44Z
dc.date.available	2023-06-06
dc.date.available	2023-11-14T04:20:44Z
dc.date.issued	2023-11
dc.identifier.citation	Infect Dis Health, 2023, 28, (4), pp. 290-297
dc.identifier.issn	2468-0451
dc.identifier.issn	2468-0869
dc.identifier.uri	http://hdl.handle.net/10453/173402
dc.description.abstract	BACKGROUND: Evidence from a previous systematic review indicates that patients admitted to a room where the previous occupant had a multidrug-resistant bacterial infection resulted in an increased risk of subsequent colonisation and infection with the same organism for the next room occupant. In this paper, we have sought to expand and update this review. METHODS: A systematic review and meta-analysis was undertaken. A search using Medline/PubMed, Cochrane and CINHAL databases was conducted. Risk of bias was assessed by the ROB-2 tool for randomised control studies and ROBIN-I for non-randomised studies. RESULTS: From 5175 identified, 12 papers from 11 studies were included in the review for analysis. From 28,299 patients who were admitted into a room where the prior room occupant had any of the organisms of interest, 651 (2.3%) were shown to acquire the same species of organism. In contrast, 981,865 patients were admitted to a room where the prior occupant did not have an organism of interest, 3818 (0.39%) acquired an organism(s). The pooled acquisition odds ratio (OR) for all the organisms across all studies was 2.45 (95% CI: 1.53-3.93]. There was heterogeneity between the studies (I2 89%, P < 0.001). CONCLUSION: The pooled OR for all the pathogens in this latest review has increased since the original review. Findings from our review provide some evidence to help inform a risk management approach when determining patient room allocation. The risk of pathogen acquisition appears to remain high, supporting the need for continued investment in this area.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Infect Dis Health
dc.relation.isbasedon	10.1016/j.idh.2023.06.001
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1110 Nursing, 1117 Public Health and Health Services
dc.subject.classification	4202 Epidemiology
dc.subject.classification	4205 Nursing
dc.subject.classification	4206 Public health
dc.subject.mesh	Humans
dc.subject.mesh	Cross Infection
dc.subject.mesh	Hospitalization
dc.subject.mesh	Patients' Rooms
dc.subject.mesh	Humans
dc.subject.mesh	Cross Infection
dc.subject.mesh	Hospitalization
dc.subject.mesh	Patients' Rooms
dc.title	Risk of organism acquisition from prior room occupants: An updated systematic review.
dc.type	Journal Article
utslib.citation.volume	28
utslib.location.activity	Netherlands
utslib.for	1103 Clinical Sciences
utslib.for	1110 Nursing
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/WHO Collaborating Centre
utslib.copyright.status	open_access	*
dc.date.updated	2023-11-14T04:20:43Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	28
utslib.citation.issue	4

Abstract:

BACKGROUND: Evidence from a previous systematic review indicates that patients admitted to a room where the previous occupant had a multidrug-resistant bacterial infection resulted in an increased risk of subsequent colonisation and infection with the same organism for the next room occupant. In this paper, we have sought to expand and update this review. METHODS: A systematic review and meta-analysis was undertaken. A search using Medline/PubMed, Cochrane and CINHAL databases was conducted. Risk of bias was assessed by the ROB-2 tool for randomised control studies and ROBIN-I for non-randomised studies. RESULTS: From 5175 identified, 12 papers from 11 studies were included in the review for analysis. From 28,299 patients who were admitted into a room where the prior room occupant had any of the organisms of interest, 651 (2.3%) were shown to acquire the same species of organism. In contrast, 981,865 patients were admitted to a room where the prior occupant did not have an organism of interest, 3818 (0.39%) acquired an organism(s). The pooled acquisition odds ratio (OR) for all the organisms across all studies was 2.45 (95% CI: 1.53-3.93]. There was heterogeneity between the studies (I2 89%, P < 0.001). CONCLUSION: The pooled OR for all the pathogens in this latest review has increased since the original review. Findings from our review provide some evidence to help inform a risk management approach when determining patient room allocation. The risk of pathogen acquisition appears to remain high, supporting the need for continued investment in this area.

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http://hdl.handle.net/10453/173402