Antibody response to different COVID-19 vaccines among the migrant workers of Bangladesh.
- Publisher:
- FRONTIERS MEDIA SA
- Publication Type:
- Journal Article
- Citation:
- Front Immunol, 2023, 14, pp. 1128330
- Issue Date:
- 2023
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Hossain, MI | |
dc.contributor.author | Sarker, P | |
dc.contributor.author | Raqib, R | |
dc.contributor.author | Rahman, MZ | |
dc.contributor.author | Hasan, R | |
dc.contributor.author | Svezia, CK | |
dc.contributor.author | Rahman, M | |
dc.contributor.author | Amin, N | |
dc.date.accessioned | 2024-01-02T23:10:42Z | |
dc.date.available | 2023-02-23 | |
dc.date.available | 2024-01-02T23:10:42Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Front Immunol, 2023, 14, pp. 1128330 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | http://hdl.handle.net/10453/173927 | |
dc.description.abstract | BACKGROUND: Due to the ongoing COVID-19 pandemic, various host countries such as Singapore, imposed entry requirements for migrant workers including pre-departure COVID-19 seroconversion proof. To combat COVID-19 worldwide, several vaccines have acquired conditional approval. This study sought to assess antibody levels after immunization with different COVID-19 vaccines among the migrant workers of Bangladesh. METHODS: Venous blood samples were collected from migrant workers who were vaccinated with different COVID-19 vaccines (n=675). Antibodies to SARS-CoV-2 spike protein (S) and nucleocapsid protein (N) were determined using Roche Elecsys® Anti-SARS-CoV-2 S and N immunoassay, respectively. RESULTS: All participants receiving COVID-19 vaccines showed antibodies to S-protein, while 91.36% were positive for N-specific antibodies. The highest anti-S antibody titers were found among the workers who completed booster doses (13327 U/mL), received mRNA vaccines Moderna/Spikevax (9459 U/mL) or Pfizer-BioNTech/Comirnaty (9181 U/mL), and reported SARS-CoV-2 infection in the last six months (8849 U/mL). The median anti-S antibody titers in the first month since the last vaccination was 8184 U/mL, which declined to 5094 U/mL at the end of six months. A strong correlation of anti-S antibodies was found with past SARS-CoV-2 infection (p < 0.001) and the type of vaccines received (p <0.001) in the workers.Conclusion: Bangladeshi migrant workers receiving booster doses of vaccine, vaccinated with mRNA vaccines, and having past SARS-CoV-2 infection, mounted higher antibody responses. However, antibody levels waned with time. These findings suggest a need for further booster doses, preferably with mRNA vaccines for migrant workers before reaching host countries. | |
dc.format | Electronic-eCollection | |
dc.language | eng | |
dc.publisher | FRONTIERS MEDIA SA | |
dc.relation.ispartof | Front Immunol | |
dc.relation.isbasedon | 10.3389/fimmu.2023.1128330 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 1107 Immunology, 1108 Medical Microbiology | |
dc.subject.classification | 3101 Biochemistry and cell biology | |
dc.subject.classification | 3105 Genetics | |
dc.subject.classification | 3204 Immunology | |
dc.subject.mesh | Humans | |
dc.subject.mesh | COVID-19 Vaccines | |
dc.subject.mesh | COVID-19 | |
dc.subject.mesh | Bangladesh | |
dc.subject.mesh | Antibody Formation | |
dc.subject.mesh | Pandemics | |
dc.subject.mesh | Transients and Migrants | |
dc.subject.mesh | SARS-CoV-2 | |
dc.subject.mesh | Antibodies | |
dc.subject.mesh | Blood Group Antigens | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Antibodies | |
dc.subject.mesh | Blood Group Antigens | |
dc.subject.mesh | Antibody Formation | |
dc.subject.mesh | Transients and Migrants | |
dc.subject.mesh | Bangladesh | |
dc.subject.mesh | Pandemics | |
dc.subject.mesh | COVID-19 | |
dc.subject.mesh | SARS-CoV-2 | |
dc.subject.mesh | COVID-19 Vaccines | |
dc.subject.mesh | Humans | |
dc.subject.mesh | COVID-19 Vaccines | |
dc.subject.mesh | COVID-19 | |
dc.subject.mesh | Bangladesh | |
dc.subject.mesh | Antibody Formation | |
dc.subject.mesh | Pandemics | |
dc.subject.mesh | Transients and Migrants | |
dc.subject.mesh | SARS-CoV-2 | |
dc.subject.mesh | Antibodies | |
dc.subject.mesh | Blood Group Antigens | |
dc.title | Antibody response to different COVID-19 vaccines among the migrant workers of Bangladesh. | |
dc.type | Journal Article | |
utslib.citation.volume | 14 | |
utslib.location.activity | Switzerland | |
utslib.for | 1107 Immunology | |
utslib.for | 1108 Medical Microbiology | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/DVC (Research) | |
pubs.organisational-group | /University of Technology Sydney/DVC (Research)/Institute For Sustainable Futures | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2024-01-02T23:10:37Z | |
pubs.publication-status | Published online | |
pubs.volume | 14 |
Abstract:
BACKGROUND: Due to the ongoing COVID-19 pandemic, various host countries such as Singapore, imposed entry requirements for migrant workers including pre-departure COVID-19 seroconversion proof. To combat COVID-19 worldwide, several vaccines have acquired conditional approval. This study sought to assess antibody levels after immunization with different COVID-19 vaccines among the migrant workers of Bangladesh. METHODS: Venous blood samples were collected from migrant workers who were vaccinated with different COVID-19 vaccines (n=675). Antibodies to SARS-CoV-2 spike protein (S) and nucleocapsid protein (N) were determined using Roche Elecsys® Anti-SARS-CoV-2 S and N immunoassay, respectively. RESULTS: All participants receiving COVID-19 vaccines showed antibodies to S-protein, while 91.36% were positive for N-specific antibodies. The highest anti-S antibody titers were found among the workers who completed booster doses (13327 U/mL), received mRNA vaccines Moderna/Spikevax (9459 U/mL) or Pfizer-BioNTech/Comirnaty (9181 U/mL), and reported SARS-CoV-2 infection in the last six months (8849 U/mL). The median anti-S antibody titers in the first month since the last vaccination was 8184 U/mL, which declined to 5094 U/mL at the end of six months. A strong correlation of anti-S antibodies was found with past SARS-CoV-2 infection (p < 0.001) and the type of vaccines received (p <0.001) in the workers.Conclusion: Bangladeshi migrant workers receiving booster doses of vaccine, vaccinated with mRNA vaccines, and having past SARS-CoV-2 infection, mounted higher antibody responses. However, antibody levels waned with time. These findings suggest a need for further booster doses, preferably with mRNA vaccines for migrant workers before reaching host countries.
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