Increased iron utilization and oxidative stress tolerance in a Vibrio cholerae flrA mutant confers resistance to amoeba predation.
- Publisher:
- AMER SOC MICROBIOLOGY
- Publication Type:
- Journal Article
- Citation:
- Appl Environ Microbiol, 2023, 89, (11), pp. e0109523
- Issue Date:
- 2023-11-29
Closed Access
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Increased iron utilization and oxidative stress tolerance in a iVibrio cholerae flrAi mutant confers resistance to amoeba pr.pdf | 3.2 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Hoque, MM | |
dc.contributor.author |
Noorian, P https://orcid.org/0000-0002-4215-1080 |
|
dc.contributor.author | Espinoza-Vergara, G | |
dc.contributor.author | Adhikary, S | |
dc.contributor.author |
To, J https://orcid.org/0000-0003-3482-4369 |
|
dc.contributor.author | Rice, SA | |
dc.contributor.author | McDougald, D | |
dc.contributor.editor | Alexandre, G | |
dc.date.accessioned | 2024-01-10T23:33:12Z | |
dc.date.available | 2024-01-10T23:33:12Z | |
dc.date.issued | 2023-11-29 | |
dc.identifier.citation | Appl Environ Microbiol, 2023, 89, (11), pp. e0109523 | |
dc.identifier.issn | 0099-2240 | |
dc.identifier.issn | 1098-5336 | |
dc.identifier.uri | http://hdl.handle.net/10453/174247 | |
dc.description.abstract | Persistence of V. cholerae in the aquatic environment contributes to the fatal diarrheal disease cholera, which remains a global health burden. In the environment, bacteria face predation pressure by heterotrophic protists such as the free-living amoeba A. castellanii. This study explores how a mutant of V. cholerae adapts to acquire essential nutrients and survive predation. Here, we observed that up-regulation of iron acquisition genes and genes regulating resistance to oxidative stress enhances pathogen fitness. Our data show that V. cholerae can defend predation to overcome nutrient limitation and oxidative stress, resulting in an enhanced survival inside the protozoan hosts. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | AMER SOC MICROBIOLOGY | |
dc.relation | http://purl.org/au-research/grants/arc/DP170100453 | |
dc.relation.ispartof | Appl Environ Microbiol | |
dc.relation.isbasedon | 10.1128/aem.01095-23 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject.classification | Microbiology | |
dc.subject.classification | 3107 Microbiology | |
dc.subject.classification | 3207 Medical microbiology | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Vibrio cholerae | |
dc.subject.mesh | Amoeba | |
dc.subject.mesh | Predatory Behavior | |
dc.subject.mesh | Cholera | |
dc.subject.mesh | Iron | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Amoeba | |
dc.subject.mesh | Vibrio cholerae | |
dc.subject.mesh | Cholera | |
dc.subject.mesh | Iron | |
dc.subject.mesh | Predatory Behavior | |
dc.title | Increased iron utilization and oxidative stress tolerance in a Vibrio cholerae flrA mutant confers resistance to amoeba predation. | |
dc.type | Journal Article | |
utslib.citation.volume | 89 | |
utslib.location.activity | United States | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - AIMI - Australian Institute for Microbiology & Infection | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2024-01-10T23:33:07Z | |
pubs.issue | 11 | |
pubs.publication-status | Published | |
pubs.volume | 89 | |
utslib.citation.issue | 11 |
Abstract:
Persistence of V. cholerae in the aquatic environment contributes to the fatal diarrheal disease cholera, which remains a global health burden. In the environment, bacteria face predation pressure by heterotrophic protists such as the free-living amoeba A. castellanii. This study explores how a mutant of V. cholerae adapts to acquire essential nutrients and survive predation. Here, we observed that up-regulation of iron acquisition genes and genes regulating resistance to oxidative stress enhances pathogen fitness. Our data show that V. cholerae can defend predation to overcome nutrient limitation and oxidative stress, resulting in an enhanced survival inside the protozoan hosts.
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