Genomic analysis of diverse environmental Acinetobacter isolates identifies plasmids, antibiotic resistance genes, and capsular polysaccharides shared with clinical strains.

Tobin, LA; Jarocki, VM; Kenyon, J; Drigo, B; Donner, E; Djordjevic, SP; Hamidian, M

Genomic analysis of diverse environmental Acinetobacter isolates identifies plasmids, antibiotic resistance genes, and capsular polysaccharides shared with clinical strains.

Tobin, LA Jarocki, VM Kenyon, J Drigo, B Donner, E Djordjevic, SP Hamidian, M

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Publisher:: American Society for Microbiology
Publication Type:: Journal Article
Citation:: Appl Environ Microbiol, 2024, pp. e0165423
Issue Date:: 2024-01-11

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Field	Value	Language
dc.contributor.author	Tobin, LA
dc.contributor.author	Jarocki, VM
dc.contributor.author	Kenyon, J
dc.contributor.author	Drigo, B
dc.contributor.author	Donner, E
dc.contributor.author	Djordjevic, SP
dc.contributor.author	Hamidian, M https://orcid.org/0000-0002-3614-7261
dc.contributor.editor	Elkins, CA
dc.date.accessioned	2024-01-15T05:58:11Z
dc.date.available	2024-01-15T05:58:11Z
dc.date.issued	2024-01-11
dc.identifier.citation	Appl Environ Microbiol, 2024, pp. e0165423
dc.identifier.issn	0099-2240
dc.identifier.issn	1098-5336
dc.identifier.uri	http://hdl.handle.net/10453/174487
dc.description.abstract	Antimicrobial resistance (AMR) is a global threat to human, animal, and environmental health. Studying AMR in environmental bacteria is crucial to understand the emergence and dissemination of resistance genes and pathogens, and to identify potential reservoirs and transmission routes. This study provides novel insights into the genomic diversity and AMR potential of environmental Acinetobacter species. By comparing the genomes of aquatic Acinetobacter isolates with clinical and non-clinical strains, we revealed that they are highly divergent yet carry pdif modules that encode resistance to antibiotics commonly used in clinical settings. We also demonstrated that an environmental A. baumannii isolate can acquire clinically relevant plasmids and carries virulence factors similar to those of hospital-associated strains. These findings suggest that environmental Acinetobacter species may serve as reservoirs and vectors of clinically important genes. Consequently, further research is warranted to comprehensively understand the ecology and evolution of this genus.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American Society for Microbiology
dc.relation.ispartof	Appl Environ Microbiol
dc.relation.isbasedon	10.1128/aem.01654-23
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Microbiology
dc.subject.classification	3107 Microbiology
dc.subject.classification	3207 Medical microbiology
dc.title	Genomic analysis of diverse environmental Acinetobacter isolates identifies plasmids, antibiotic resistance genes, and capsular polysaccharides shared with clinical strains.
dc.type	Journal Article
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - AIMI - Australian Institute for Microbiology & Infection
utslib.copyright.status	closed_access	*
dc.date.updated	2024-01-15T05:58:09Z
pubs.publication-status	Published online

Abstract:

Antimicrobial resistance (AMR) is a global threat to human, animal, and environmental health. Studying AMR in environmental bacteria is crucial to understand the emergence and dissemination of resistance genes and pathogens, and to identify potential reservoirs and transmission routes. This study provides novel insights into the genomic diversity and AMR potential of environmental Acinetobacter species. By comparing the genomes of aquatic Acinetobacter isolates with clinical and non-clinical strains, we revealed that they are highly divergent yet carry pdif modules that encode resistance to antibiotics commonly used in clinical settings. We also demonstrated that an environmental A. baumannii isolate can acquire clinically relevant plasmids and carries virulence factors similar to those of hospital-associated strains. These findings suggest that environmental Acinetobacter species may serve as reservoirs and vectors of clinically important genes. Consequently, further research is warranted to comprehensively understand the ecology and evolution of this genus.

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http://hdl.handle.net/10453/174487