Modeling nontuberculous mycobacterial infections in zebrafish.

Johansen, MD; Spaink, HP; Oehlers, SH; Kremer, L

Modeling nontuberculous mycobacterial infections in zebrafish.

Johansen, MD Spaink, HP Oehlers, SH Kremer, L

Permalink

Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Trends Microbiol, 2023, pp. S0966-842X(23)00329-3
Issue Date:: 2023-12-21

Embargoed

	Filename	Description	Size
	TIMI-S-23-00302-1.pdf	Submitted version	3.82 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Embargoed
Open Access

This item is currently unavailable due to the publisher's embargo.

The embargo period expires on 1 Dec 2024

Full metadata record

Field	Value	Language
dc.contributor.author	Johansen, MD
dc.contributor.author	Spaink, HP
dc.contributor.author	Oehlers, SH
dc.contributor.author	Kremer, L
dc.date.accessioned	2024-01-16T02:09:18Z
dc.date.available	2023-11-27
dc.date.available	2024-01-16T02:09:18Z
dc.date.issued	2023-12-21
dc.identifier.citation	Trends Microbiol, 2023, pp. S0966-842X(23)00329-3
dc.identifier.issn	0966-842X
dc.identifier.issn	1878-4380
dc.identifier.uri	http://hdl.handle.net/10453/174545
dc.description.abstract	The incidence of infections due to nontuberculous mycobacteria (NTM) has increased rapidly in recent years, surpassing tuberculosis in developed countries. Due to inherent antimicrobial resistance, NTM infections are particularly difficult to treat with low cure rates. There is an urgent need to understand NTM pathogenesis and to develop novel therapeutic approaches for the treatment of NTM diseases. Zebrafish have emerged as an excellent animal model due to genetic amenability and optical transparency during embryonic development, allowing spatiotemporal visualization of host-pathogen interactions. Furthermore, adult zebrafish possess fully functional innate and adaptive immunity and recapitulate important pathophysiological hallmarks of mycobacterial infection. Here, we report recent breakthroughs in understanding the hallmarks of NTM infections using the zebrafish model.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Trends Microbiol
dc.relation.isbasedon	10.1016/j.tim.2023.11.011
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	0605 Microbiology, 1108 Medical Microbiology
dc.subject.classification	Microbiology
dc.subject.classification	3101 Biochemistry and cell biology
dc.subject.classification	3107 Microbiology
dc.title	Modeling nontuberculous mycobacterial infections in zebrafish.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	0605 Microbiology
utslib.for	1108 Medical Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	embargoed	*
utslib.copyright.embargo	2024-12-01T00:00:00+1000Z
dc.date.updated	2024-01-16T02:09:17Z
pubs.publication-status	Published online

Abstract:

The incidence of infections due to nontuberculous mycobacteria (NTM) has increased rapidly in recent years, surpassing tuberculosis in developed countries. Due to inherent antimicrobial resistance, NTM infections are particularly difficult to treat with low cure rates. There is an urgent need to understand NTM pathogenesis and to develop novel therapeutic approaches for the treatment of NTM diseases. Zebrafish have emerged as an excellent animal model due to genetic amenability and optical transparency during embryonic development, allowing spatiotemporal visualization of host-pathogen interactions. Furthermore, adult zebrafish possess fully functional innate and adaptive immunity and recapitulate important pathophysiological hallmarks of mycobacterial infection. Here, we report recent breakthroughs in understanding the hallmarks of NTM infections using the zebrafish model.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/174545