Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery.

Chaudhary, B; Kumar, P; Arya, P; Singla, D; Kumar, V; Kumar, D; S, R; Wadhwa, S; Gulati, M; Singh, SK; Dua, K; Gupta, G; Gupta, MM

Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery.

Chaudhary, B Kumar, P Arya, P Singla, D Kumar, V Kumar, D S, R Wadhwa, S Gulati, M Singh, SK Dua, K

Gupta, G Gupta, MM

Permalink

Publisher:: Bentham Science Publishers
Publication Type:: Journal Article
Citation:: Curr Drug Metab, 2023, 23, (13), pp. 1027-1053
Issue Date:: 2023-01-10

Closed Access

	Filename	Description	Size
	21974887_12718804590005671.pdf	Published version	7.3 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Chaudhary, B
dc.contributor.author	Kumar, P
dc.contributor.author	Arya, P
dc.contributor.author	Singla, D
dc.contributor.author	Kumar, V
dc.contributor.author	Kumar, D
dc.contributor.author	S, R
dc.contributor.author	Wadhwa, S
dc.contributor.author	Gulati, M
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Gupta, G
dc.contributor.author	Gupta, MM
dc.date.accessioned	2024-02-04T23:09:39Z
dc.date.available	2022-11-29
dc.date.available	2024-02-04T23:09:39Z
dc.date.issued	2023-01-10
dc.identifier.citation	Curr Drug Metab, 2023, 23, (13), pp. 1027-1053
dc.identifier.issn	1389-2002
dc.identifier.issn	1875-5453
dc.identifier.uri	http://hdl.handle.net/10453/175275
dc.description.abstract	Cancer is characterized by disrupted molecular variables caused by cells that deviate from regular signal transduction. The uncontrolled segment of such cancerous cells annihilates most of the tissues that contact them. Gene therapy, immunotherapy, and nanotechnology advancements have resulted in novel strategies for anticancer drug delivery. Furthermore, diverse dispersion of nanoparticles in normal stroma cells adversely affects the healthy cells and disrupts the crosstalk of tumour stroma. It can contribute to cancer cell progression inhibition and, conversely, to acquired resistance, enabling cancer cell metastasis and proliferation. The tumour's microenvironment is critical in controlling the dispersion and physiological activities of nano-chemotherapeutics which is one of the targeted drug therapy. As it is one of the methods of treating cancer that involves the use of medications or other substances to specifically target and kill off certain subsets of malignant cells. A targeted therapy may be administered alone or in addition to more conventional methods of care like surgery, chemotherapy, or radiation treatment. The tumour microenvironment, stromatogenesis, barriers and advancement in the drug delivery system across tumour tissue are summarised in this review.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Bentham Science Publishers
dc.relation.ispartof	Curr Drug Metab
dc.relation.isbasedon	10.2174/1389200224666230110145513
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.title	Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery.
dc.type	Journal Article
utslib.citation.volume	23
utslib.location.activity	Netherlands
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	closed_access	*
dc.date.updated	2024-02-04T23:09:36Z
pubs.issue	13
pubs.publication-status	Published online
pubs.volume	23
utslib.citation.issue	13

Abstract:

Cancer is characterized by disrupted molecular variables caused by cells that deviate from regular signal transduction. The uncontrolled segment of such cancerous cells annihilates most of the tissues that contact them. Gene therapy, immunotherapy, and nanotechnology advancements have resulted in novel strategies for anticancer drug delivery. Furthermore, diverse dispersion of nanoparticles in normal stroma cells adversely affects the healthy cells and disrupts the crosstalk of tumour stroma. It can contribute to cancer cell progression inhibition and, conversely, to acquired resistance, enabling cancer cell metastasis and proliferation. The tumour's microenvironment is critical in controlling the dispersion and physiological activities of nano-chemotherapeutics which is one of the targeted drug therapy. As it is one of the methods of treating cancer that involves the use of medications or other substances to specifically target and kill off certain subsets of malignant cells. A targeted therapy may be administered alone or in addition to more conventional methods of care like surgery, chemotherapy, or radiation treatment. The tumour microenvironment, stromatogenesis, barriers and advancement in the drug delivery system across tumour tissue are summarised in this review.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/175275