Retrospective evaluation of an integrated molecular-epidemiological approach to cyclosporiasis outbreak investigations - United States, 2021.
Ahart, L
Jacobson, D
Rice, M
Richins, T
Peterson, A
Zheng, Y
Barratt, J
Cama, V
Qvarnstrom, Y
Montgomery, S
Straily, A
- Publisher:
- Cambridge University Press (CUP)
- Publication Type:
- Journal Article
- Citation:
- Epidemiol Infect, 2023, 151, pp. e131
- Issue Date:
- 2023-07-19
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Ahart, L | |
dc.contributor.author | Jacobson, D | |
dc.contributor.author | Rice, M | |
dc.contributor.author | Richins, T | |
dc.contributor.author | Peterson, A | |
dc.contributor.author | Zheng, Y | |
dc.contributor.author |
Barratt, J https://orcid.org/0000-0001-8711-2408 |
|
dc.contributor.author | Cama, V | |
dc.contributor.author | Qvarnstrom, Y | |
dc.contributor.author | Montgomery, S | |
dc.contributor.author | Straily, A | |
dc.date.accessioned | 2024-02-06T04:05:52Z | |
dc.date.available | 2024-02-06T04:05:52Z | |
dc.date.issued | 2023-07-19 | |
dc.identifier.citation | Epidemiol Infect, 2023, 151, pp. e131 | |
dc.identifier.issn | 0950-2688 | |
dc.identifier.issn | 1469-4409 | |
dc.identifier.uri | http://hdl.handle.net/10453/175359 | |
dc.description.abstract | Cyclosporiasis results from an infection of the small intestine by Cyclospora parasites after ingestion of contaminated food or water, often leading to gastrointestinal distress. Recent developments in temporally linking genetically related Cyclospora isolates demonstrated effectiveness in supporting epidemiological investigations. We used 'temporal-genetic clusters' (TGCs) to investigate reported cyclosporiasis cases in the United States during the 2021 peak-period (1 May - 31 August 2021). Our approach split 655 genotyped isolates into 55 genetic clusters and 31 TGCs. We linked two large multi-state epidemiological clusters (Epidemiologic Cluster 1 [n = 136 cases, 54 genotyped] and Epidemiologic Cluster 2 [n = 42 cases, 15 genotyped]) to consumption of lettuce varieties; however, product traceback did not identify a specific product for either cluster due to the lack of detailed product information. To evaluate the utility of TGCs, we performed a retrospective case study comparing investigation outcomes of outbreaks first detected using epidemiological methods with those of the same outbreaks had TGCs been used to first detect them. Our study results indicate that adjustments to routine epidemiological approaches could link additional cases to epidemiological clusters of cyclosporiasis. Overall, we show that CDC's integrated genotyping and epidemiological investigations provide valuable insights into cyclosporiasis outbreaks in the United States. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | Cambridge University Press (CUP) | |
dc.relation.ispartof | Epidemiol Infect | |
dc.relation.isbasedon | 10.1017/S0950268823001176 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 1117 Public Health and Health Services | |
dc.subject.classification | Epidemiology | |
dc.subject.classification | 3009 Veterinary sciences | |
dc.subject.classification | 3202 Clinical sciences | |
dc.subject.classification | 4202 Epidemiology | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Cyclosporiasis | |
dc.subject.mesh | Cyclospora | |
dc.subject.mesh | Disease Outbreaks | |
dc.subject.mesh | Molecular Epidemiology | |
dc.subject.mesh | United States | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Feces | |
dc.subject.mesh | Feces | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Cyclospora | |
dc.subject.mesh | Cyclosporiasis | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Disease Outbreaks | |
dc.subject.mesh | United States | |
dc.subject.mesh | Molecular Epidemiology | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Cyclosporiasis | |
dc.subject.mesh | Cyclospora | |
dc.subject.mesh | Disease Outbreaks | |
dc.subject.mesh | Molecular Epidemiology | |
dc.subject.mesh | United States | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Feces | |
dc.title | Retrospective evaluation of an integrated molecular-epidemiological approach to cyclosporiasis outbreak investigations - United States, 2021. | |
dc.type | Journal Article | |
utslib.citation.volume | 151 | |
utslib.location.activity | England | |
utslib.for | 1117 Public Health and Health Services | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science/School of Life Sciences | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2024-02-06T04:05:51Z | |
pubs.publication-status | Published online | |
pubs.volume | 151 |
Abstract:
Cyclosporiasis results from an infection of the small intestine by Cyclospora parasites after ingestion of contaminated food or water, often leading to gastrointestinal distress. Recent developments in temporally linking genetically related Cyclospora isolates demonstrated effectiveness in supporting epidemiological investigations. We used 'temporal-genetic clusters' (TGCs) to investigate reported cyclosporiasis cases in the United States during the 2021 peak-period (1 May - 31 August 2021). Our approach split 655 genotyped isolates into 55 genetic clusters and 31 TGCs. We linked two large multi-state epidemiological clusters (Epidemiologic Cluster 1 [n = 136 cases, 54 genotyped] and Epidemiologic Cluster 2 [n = 42 cases, 15 genotyped]) to consumption of lettuce varieties; however, product traceback did not identify a specific product for either cluster due to the lack of detailed product information. To evaluate the utility of TGCs, we performed a retrospective case study comparing investigation outcomes of outbreaks first detected using epidemiological methods with those of the same outbreaks had TGCs been used to first detect them. Our study results indicate that adjustments to routine epidemiological approaches could link additional cases to epidemiological clusters of cyclosporiasis. Overall, we show that CDC's integrated genotyping and epidemiological investigations provide valuable insights into cyclosporiasis outbreaks in the United States.
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