Mass drug administration campaigns for scabies and impetigo: protocol for a systematic review and meta-analysis.

Ghosh, P; Tesfaye, W; Manandhar, A; Calma, T; Bushell, M; Oguoma, VM; Kosari, S; McMillan, F; Peterson, G; Thomas, J

Mass drug administration campaigns for scabies and impetigo: protocol for a systematic review and meta-analysis.

Ghosh, P Tesfaye, W Manandhar, A Calma, T Bushell, M Oguoma, VM Kosari, S McMillan, F

Peterson, G Thomas, J

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Publisher:: BMJ PUBLISHING GROUP
Publication Type:: Journal Article
Citation:: BMJ Paediatr Open, 2021, 5, (1), pp. e001132
Issue Date:: 2021

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Field	Value	Language
dc.contributor.author	Ghosh, P
dc.contributor.author	Tesfaye, W
dc.contributor.author	Manandhar, A
dc.contributor.author	Calma, T
dc.contributor.author	Bushell, M
dc.contributor.author	Oguoma, VM
dc.contributor.author	Kosari, S
dc.contributor.author	McMillan, F https://orcid.org/0000-0002-9441-7805
dc.contributor.author	Peterson, G
dc.contributor.author	Thomas, J
dc.date.accessioned	2024-03-05T23:27:58Z
dc.date.available	2021-05-27
dc.date.available	2024-03-05T23:27:58Z
dc.date.issued	2021
dc.identifier.citation	BMJ Paediatr Open, 2021, 5, (1), pp. e001132
dc.identifier.issn	2399-9772
dc.identifier.issn	2399-9772
dc.identifier.uri	http://hdl.handle.net/10453/176152
dc.description.abstract	INTRODUCTION: Scabies is recognised as a neglected tropical disease, disproportionately affecting the most vulnerable populations around the world. Impetigo often occurs secondarily to scabies. Several studies have explored mass drug administration (MDA) programmes, with some showing positive outcomes-but a systematic evaluation of such studies is yet to be reported. The main aim of this systematic review is to generate comprehensive evidence on the effect and feasibility of MDA programmes in reducing the burden of scabies and impetigo. METHODS AND ANALYSIS: A systematic review and meta-analysis will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Electronic databases to be searched will include CINAHL EBSCOhost, Medline Ovid, ProQuest, Science Direct, PubMed and SCOPUS. In addition, grey literature will be explored via the Australian Institute of Health and Welfare, Australian Indigenous HealthInfoNet, Informit, OaIster database and WHO. No language restrictions will be applied. All treatment studies following an MDA protocol, including randomised/quasi-controlled trials, and prospective before-after interventional studies, will be considered. The main outcome is the change in prevalence of scabies and impetigo The Cochrane collaboration risk of bias assessment tool will be used for assessing the methodological quality of studies. A random-effect restricted maximum likelihood meta-analysis will be performed to generate pooled effect (OR) using STATA V.16. Appropriate statistical tests will be carried out to quantify heterogeneity between studies and publication bias. ETHICS AND DISSEMINATION: Ethical approval is not required since data will be extracted from published works. The findings will be communicated to the scientific community through a peer-reviewed journal publication. This systematic review will present an evidence on the effect of MDA interventions on scabies and impetigo, which is instrumental to obtain a clear understanding of the treatments widely used in these programmes. PROSPERO REGISTRATION NUMBER: CRD42020169544.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	BMJ PUBLISHING GROUP
dc.relation.ispartof	BMJ Paediatr Open
dc.relation.isbasedon	10.1136/bmjpo-2021-001132
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	3213 Paediatrics
dc.subject.mesh	Australia
dc.subject.mesh	Humans
dc.subject.mesh	Impetigo
dc.subject.mesh	Mass Drug Administration
dc.subject.mesh	Meta-Analysis as Topic
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Scabies
dc.subject.mesh	Systematic Reviews as Topic
dc.subject.mesh	Humans
dc.subject.mesh	Impetigo
dc.subject.mesh	Scabies
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Australia
dc.subject.mesh	Meta-Analysis as Topic
dc.subject.mesh	Mass Drug Administration
dc.subject.mesh	Systematic Reviews as Topic
dc.subject.mesh	Australia
dc.subject.mesh	Humans
dc.subject.mesh	Impetigo
dc.subject.mesh	Mass Drug Administration
dc.subject.mesh	Meta-Analysis as Topic
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Scabies
dc.subject.mesh	Systematic Reviews as Topic
dc.title	Mass drug administration campaigns for scabies and impetigo: protocol for a systematic review and meta-analysis.
dc.type	Journal Article
utslib.citation.volume	5
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/Public Health
utslib.copyright.status	open_access	*
dc.date.updated	2024-03-05T23:27:57Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	5
utslib.citation.issue	1

Abstract:

INTRODUCTION: Scabies is recognised as a neglected tropical disease, disproportionately affecting the most vulnerable populations around the world. Impetigo often occurs secondarily to scabies. Several studies have explored mass drug administration (MDA) programmes, with some showing positive outcomes-but a systematic evaluation of such studies is yet to be reported. The main aim of this systematic review is to generate comprehensive evidence on the effect and feasibility of MDA programmes in reducing the burden of scabies and impetigo. METHODS AND ANALYSIS: A systematic review and meta-analysis will be conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Electronic databases to be searched will include CINAHL EBSCOhost, Medline Ovid, ProQuest, Science Direct, PubMed and SCOPUS. In addition, grey literature will be explored via the Australian Institute of Health and Welfare, Australian Indigenous HealthInfoNet, Informit, OaIster database and WHO. No language restrictions will be applied. All treatment studies following an MDA protocol, including randomised/quasi-controlled trials, and prospective before-after interventional studies, will be considered. The main outcome is the change in prevalence of scabies and impetigo The Cochrane collaboration risk of bias assessment tool will be used for assessing the methodological quality of studies. A random-effect restricted maximum likelihood meta-analysis will be performed to generate pooled effect (OR) using STATA V.16. Appropriate statistical tests will be carried out to quantify heterogeneity between studies and publication bias. ETHICS AND DISSEMINATION: Ethical approval is not required since data will be extracted from published works. The findings will be communicated to the scientific community through a peer-reviewed journal publication. This systematic review will present an evidence on the effect of MDA interventions on scabies and impetigo, which is instrumental to obtain a clear understanding of the treatments widely used in these programmes. PROSPERO REGISTRATION NUMBER: CRD42020169544.

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