Self-Reported Insufficient Sleep Is Associated With Clinical and Inflammatory Features of Asthma: A Prospective Cohort Study.

Wang, CY; Wang, J; Zhang, L; Zhang, SW; Wang, L; Zhao, SZ; Chen, ZH; Zhang, X; Xie, M; Wang, T; Chen-Yu Hsu, A; Qin, L; Oliver, BG; Liu, L; Wan, HJ; Liu, D; Luo, FM; Li, WM; Wang, G

Self-Reported Insufficient Sleep Is Associated With Clinical and Inflammatory Features of Asthma: A Prospective Cohort Study.

Wang, CY Wang, J Zhang, L Zhang, SW Wang, L Zhao, SZ Chen, ZH Zhang, X Xie, M Wang, T Chen-Yu Hsu, A Qin, L Oliver, BG Liu, L Wan, HJ Liu, D Luo, FM Li, WM Wang, G

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Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: J Allergy Clin Immunol Pract, 2023, 11, (4), pp. 1200-1210.e4
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Wang, CY
dc.contributor.author	Wang, J
dc.contributor.author	Zhang, L
dc.contributor.author	Zhang, SW
dc.contributor.author	Wang, L
dc.contributor.author	Zhao, SZ
dc.contributor.author	Chen, ZH
dc.contributor.author	Zhang, X
dc.contributor.author	Xie, M
dc.contributor.author	Wang, T
dc.contributor.author	Chen-Yu Hsu, A
dc.contributor.author	Qin, L
dc.contributor.author	Oliver, BG
dc.contributor.author	Liu, L
dc.contributor.author	Wan, HJ
dc.contributor.author	Liu, D
dc.contributor.author	Luo, FM
dc.contributor.author	Li, WM
dc.contributor.author	Wang, G
dc.date.accessioned	2024-03-12T04:12:47Z
dc.date.available	2022-12-06
dc.date.available	2024-03-12T04:12:47Z
dc.date.issued	2023
dc.identifier.citation	J Allergy Clin Immunol Pract, 2023, 11, (4), pp. 1200-1210.e4
dc.identifier.issn	2213-2198
dc.identifier.issn	2213-2201
dc.identifier.uri	http://hdl.handle.net/10453/176560
dc.description.abstract	BACKGROUND: A few studies have explored the association between short sleep duration and worse asthma outcomes in patients with self-reported asthma; however, all of them were cross-sectional. OBJECTIVES: To investigate the association between self-reported sleep duration and asthma-related clinical and inflammatory characteristics and whether sleep duration is associated with asthma exacerbations (AEs) in the following year. METHODS: A prospective cohort study consecutively recruited participants with asthma, who were classified into short (n = 58), normal (n = 380), and long (n = 84) sleep duration groups. We investigated the clinical and inflammatory characteristics and exacerbations within a 1-year follow-up. RESULTS: Patients with short sleep duration were older and had significantly lower total IgE and FeNO levels and higher airway inflammation, characterized by increased levels of IL-6 and TNF-α in sputum than those of patients with normal sleep duration. Furthermore, they had a significantly increased risk for poorly controlled asthma (adjusted odds ratio = 2.741; 95% CI, 1.379-5.447; P = .004) and moderate to severe AEs (adjusted incidence rate ratio = 1.798; 95% CI, 1.098-2.942; P = .020). CONCLUSIONS: Short sleep duration was associated with non-type 2 inflammation and is an independent risk factor for future AEs. Therefore, as a potentially treatable trait, sleep duration may have clinical implications for asthma management.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER
dc.relation.ispartof	J Allergy Clin Immunol Pract
dc.relation.isbasedon	10.1016/j.jaip.2022.12.011
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject.classification	3204 Immunology
dc.subject.mesh	Humans
dc.subject.mesh	Sleep Deprivation
dc.subject.mesh	Self Report
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Asthma
dc.subject.mesh	Inflammation
dc.subject.mesh	Humans
dc.subject.mesh	Asthma
dc.subject.mesh	Sleep Deprivation
dc.subject.mesh	Inflammation
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Self Report
dc.subject.mesh	Humans
dc.subject.mesh	Sleep Deprivation
dc.subject.mesh	Self Report
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Asthma
dc.subject.mesh	Inflammation
dc.title	Self-Reported Insufficient Sleep Is Associated With Clinical and Inflammatory Features of Asthma: A Prospective Cohort Study.
dc.type	Journal Article
utslib.citation.volume	11
utslib.location.activity	United States
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
utslib.copyright.embargo	2024-04-01T00:00:00+1000Z
dc.date.updated	2024-03-12T04:12:46Z
pubs.issue	4
pubs.publication-status	Published online
pubs.volume	11
utslib.citation.issue	4

Abstract:

BACKGROUND: A few studies have explored the association between short sleep duration and worse asthma outcomes in patients with self-reported asthma; however, all of them were cross-sectional. OBJECTIVES: To investigate the association between self-reported sleep duration and asthma-related clinical and inflammatory characteristics and whether sleep duration is associated with asthma exacerbations (AEs) in the following year. METHODS: A prospective cohort study consecutively recruited participants with asthma, who were classified into short (n = 58), normal (n = 380), and long (n = 84) sleep duration groups. We investigated the clinical and inflammatory characteristics and exacerbations within a 1-year follow-up. RESULTS: Patients with short sleep duration were older and had significantly lower total IgE and FeNO levels and higher airway inflammation, characterized by increased levels of IL-6 and TNF-α in sputum than those of patients with normal sleep duration. Furthermore, they had a significantly increased risk for poorly controlled asthma (adjusted odds ratio = 2.741; 95% CI, 1.379-5.447; P = .004) and moderate to severe AEs (adjusted incidence rate ratio = 1.798; 95% CI, 1.098-2.942; P = .020). CONCLUSIONS: Short sleep duration was associated with non-type 2 inflammation and is an independent risk factor for future AEs. Therefore, as a potentially treatable trait, sleep duration may have clinical implications for asthma management.

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http://hdl.handle.net/10453/176560