Small zinc doped iron oxide tracers for magnetic particle imaging

Kim Duong, HT; Abdibastami, A; Gloag, L; Bongers, A; Shanehsazzadeh, S; Nelson, M; Cousins, A; Bayat, N; McCalmont, H; Lock, RB; Sulway, S; Biazick, J; Justin Gooding, J; Tilley, RD

Small zinc doped iron oxide tracers for magnetic particle imaging

Kim Duong, HT Abdibastami, A Gloag, L

Bongers, A Shanehsazzadeh, S Nelson, M Cousins, A Bayat, N McCalmont, H Lock, RB Sulway, S Biazick, J Justin Gooding, J Tilley, RD

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Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: Journal of Magnetism and Magnetic Materials, 2023, 587
Issue Date:: 2023-12-01

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Field	Value	Language
dc.contributor.author	Kim Duong, HT
dc.contributor.author	Abdibastami, A
dc.contributor.author	Gloag, L https://orcid.org/0000-0001-7548-1521
dc.contributor.author	Bongers, A
dc.contributor.author	Shanehsazzadeh, S
dc.contributor.author	Nelson, M
dc.contributor.author	Cousins, A
dc.contributor.author	Bayat, N
dc.contributor.author	McCalmont, H
dc.contributor.author	Lock, RB
dc.contributor.author	Sulway, S
dc.contributor.author	Biazick, J
dc.contributor.author	Justin Gooding, J
dc.contributor.author	Tilley, RD
dc.date.accessioned	2024-03-15T02:57:56Z
dc.date.available	2024-03-15T02:57:56Z
dc.date.issued	2023-12-01
dc.identifier.citation	Journal of Magnetism and Magnetic Materials, 2023, 587
dc.identifier.issn	0304-8853
dc.identifier.issn	1873-4766
dc.identifier.uri	http://hdl.handle.net/10453/176761
dc.description.abstract	Magnetic particle imaging (MPI) has garnered significant attention in biomedical imaging research due to its excellent signal intensity that is generated directly from superparamagnetic iron oxide nanoparticles (SPIONs). Small nanoparticle tracers with high saturation magnetisation are crucial for MPI as they can prolong circulation, crossing the blood brain barrier and enhance cellular uptake. In this work, we demonstrate small zinc doped iron oxide nanoparticles (Zn-IONPs) are excellent MPI tracers. Our Zn-IONPs exhibited up to 37 % and 64% enhancement in saturation magnetisation (Msat) value and MPI signal intensity respectively compared to Fe3O4 of the same size. As a result, the polymer encapsulated Zn-IONPs achieved up to 2.7-fold enhancement in MPI signal intensity compared to VivoTrax. Furthermore, these polymer encapsulated NPs were also determined to be non-toxic hence making these Zn-IONPs ideal for many biomedical applications in MPI where small size is critical to prolong circulation time and crossing the blood brain barrier.
dc.language	English
dc.publisher	ELSEVIER
dc.relation.ispartof	Journal of Magnetism and Magnetic Materials
dc.relation.isbasedon	10.1016/j.jmmm.2023.171304
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0204 Condensed Matter Physics, 0912 Materials Engineering, 0913 Mechanical Engineering
dc.subject.classification	Applied Physics
dc.subject.classification	4016 Materials engineering
dc.subject.classification	5104 Condensed matter physics
dc.title	Small zinc doped iron oxide tracers for magnetic particle imaging
dc.type	Journal Article
utslib.citation.volume	587
utslib.for	0204 Condensed Matter Physics
utslib.for	0912 Materials Engineering
utslib.for	0913 Mechanical Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2024-03-15T02:57:55Z
pubs.publication-status	Published
pubs.volume	587

Abstract:

Magnetic particle imaging (MPI) has garnered significant attention in biomedical imaging research due to its excellent signal intensity that is generated directly from superparamagnetic iron oxide nanoparticles (SPIONs). Small nanoparticle tracers with high saturation magnetisation are crucial for MPI as they can prolong circulation, crossing the blood brain barrier and enhance cellular uptake. In this work, we demonstrate small zinc doped iron oxide nanoparticles (Zn-IONPs) are excellent MPI tracers. Our Zn-IONPs exhibited up to 37 % and 64% enhancement in saturation magnetisation (Msat) value and MPI signal intensity respectively compared to Fe3O4 of the same size. As a result, the polymer encapsulated Zn-IONPs achieved up to 2.7-fold enhancement in MPI signal intensity compared to VivoTrax. Furthermore, these polymer encapsulated NPs were also determined to be non-toxic hence making these Zn-IONPs ideal for many biomedical applications in MPI where small size is critical to prolong circulation time and crossing the blood brain barrier.

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http://hdl.handle.net/10453/176761