The MANGO study: a prospective investigation of oxygen enhanced and blood-oxygen level dependent MRI as imaging biomarkers of hypoxia in glioblastoma

Brighi, C; Waddington, DEJ; Keall, PJ; Booth, J; O’Brien, K; Silvester, S; Parkinson, J; Mueller, M; Yim, J; Bailey, DL; Back, M; Drummond, J

The MANGO study: a prospective investigation of oxygen enhanced and blood-oxygen level dependent MRI as imaging biomarkers of hypoxia in glioblastoma

Brighi, C Waddington, DEJ Keall, PJ Booth, J O’Brien, K Silvester, S Parkinson, J Mueller, M Yim, J Bailey, DL Back, M Drummond, J

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Publisher:: Frontiers
Publication Type:: Journal Article
Citation:: Frontiers in Oncology, 2023, 13, pp. 1306164
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Brighi, C
dc.contributor.author	Waddington, DEJ
dc.contributor.author	Keall, PJ
dc.contributor.author	Booth, J
dc.contributor.author	O’Brien, K
dc.contributor.author	Silvester, S
dc.contributor.author	Parkinson, J
dc.contributor.author	Mueller, M
dc.contributor.author	Yim, J
dc.contributor.author	Bailey, DL
dc.contributor.author	Back, M
dc.contributor.author	Drummond, J
dc.date.accessioned	2024-03-26T22:15:32Z
dc.date.available	2023-12-04
dc.date.available	2024-03-26T22:15:32Z
dc.date.issued	2023
dc.identifier.citation	Frontiers in Oncology, 2023, 13, pp. 1306164
dc.identifier.issn	2234-943X
dc.identifier.issn	2234-943X
dc.identifier.uri	http://hdl.handle.net/10453/177198
dc.description.abstract	Background Glioblastoma GBM is the most aggressive type of brain cancer with a 5 year survival rate of 5 and most tumours recurring locally within months of first line treatment Hypoxia is associated with worse clinical outcomes in GBM as it leads to localized resistance to radiotherapy and subsequent tumour recurrence Current standard of care treatment does not account for tumour hypoxia due to the challenges of mapping tumour hypoxia in routine clinical practice In this clinical study we aim to investigate the role of oxygen enhanced OE and blood oxygen level dependent BOLD MRI as non invasive imaging biomarkers of hypoxia in GBM and to evaluate their potential role in dose painting radiotherapy planning and treatment response assessment Methods The primary endpoint is to evaluate the quantitative and spatial correlation between OE and BOLD MRI measurements and sup 18 sup F MISO values of uptake in the tumour The secondary endpoints are to evaluate the repeatability of MRI biomarkers of hypoxia in a test retest study to estimate the potential clinical benefits of using MRI biomarkers of hypoxia to guide dose painting radiotherapy and to evaluate the ability of MRI biomarkers of hypoxia to assess treatment response Twenty newly diagnosed GBM patients will be enrolled in this study Patients will undergo standard of care treatment while receiving additional OE BOLD MRI and sup 18 sup F MISO PET scans at several timepoints during treatment The ability of OE BOLD MRI to map hypoxic tumour regions will be evaluated by assessing spatial and quantitative correlations with areas of hypoxic tumour identified via sup 18 sup F MISO PET imaging Discussion MANGO Magnetic resonance imaging of hypoxia for radiation treatment guidance in glioblastoma multiforme is a diagnostic prognostic study investigating the role of imaging biomarkers of hypoxia in GBM management The study will generate a large amount of longitudinal multimodal MRI and PET imaging data that could be used to unv
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Frontiers
dc.relation.ispartof	Frontiers in Oncology
dc.relation.isbasedon	10.3389/fonc.2023.1306164
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1112 Oncology and Carcinogenesis
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3211 Oncology and carcinogenesis
dc.title	The MANGO study: a prospective investigation of oxygen enhanced and blood-oxygen level dependent MRI as imaging biomarkers of hypoxia in glioblastoma
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	Switzerland
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/Centre for Health Economics Research and Evaluation
utslib.copyright.status	open_access	*
pubs.consider-herdc	true
dc.date.updated	2024-03-26T22:15:30Z
pubs.publication-status	Published
pubs.volume	13

Abstract:

Background Glioblastoma GBM is the most aggressive type of brain cancer with a 5 year survival rate of 5 and most tumours recurring locally within months of first line treatment Hypoxia is associated with worse clinical outcomes in GBM as it leads to localized resistance to radiotherapy and subsequent tumour recurrence Current standard of care treatment does not account for tumour hypoxia due to the challenges of mapping tumour hypoxia in routine clinical practice In this clinical study we aim to investigate the role of oxygen enhanced OE and blood oxygen level dependent BOLD MRI as non invasive imaging biomarkers of hypoxia in GBM and to evaluate their potential role in dose painting radiotherapy planning and treatment response assessment Methods The primary endpoint is to evaluate the quantitative and spatial correlation between OE and BOLD MRI measurements and sup 18 sup F MISO values of uptake in the tumour The secondary endpoints are to evaluate the repeatability of MRI biomarkers of hypoxia in a test retest study to estimate the potential clinical benefits of using MRI biomarkers of hypoxia to guide dose painting radiotherapy and to evaluate the ability of MRI biomarkers of hypoxia to assess treatment response Twenty newly diagnosed GBM patients will be enrolled in this study Patients will undergo standard of care treatment while receiving additional OE BOLD MRI and sup 18 sup F MISO PET scans at several timepoints during treatment The ability of OE BOLD MRI to map hypoxic tumour regions will be evaluated by assessing spatial and quantitative correlations with areas of hypoxic tumour identified via sup 18 sup F MISO PET imaging Discussion MANGO Magnetic resonance imaging of hypoxia for radiation treatment guidance in glioblastoma multiforme is a diagnostic prognostic study investigating the role of imaging biomarkers of hypoxia in GBM management The study will generate a large amount of longitudinal multimodal MRI and PET imaging data that could be used to unv

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