Nanothermometer for In Vivo Temperature Detection with High Spatial Resolution Based on Core-Shell Rare Earth Nanoparticles

Sun, Y; Kong, M; Ke, J; Yuan, W; Wen, C; Gu, Y; Luo, S; Feng, W

Nanothermometer for In Vivo Temperature Detection with High Spatial Resolution Based on Core-Shell Rare Earth Nanoparticles

Sun, Y Kong, M Ke, J Yuan, W Wen, C Gu, Y

Luo, S Feng, W

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Publisher:: AMER CHEMICAL SOC
Publication Type:: Journal Article
Citation:: ACS Applied Nano Materials, 2023, 6, (24), pp. 23173-23183
Issue Date:: 2023-12-22

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Field	Value	Language
dc.contributor.author	Sun, Y
dc.contributor.author	Kong, M
dc.contributor.author	Ke, J
dc.contributor.author	Yuan, W
dc.contributor.author	Wen, C
dc.contributor.author	Gu, Y https://orcid.org/0000-0002-0826-1868
dc.contributor.author	Luo, S
dc.contributor.author	Feng, W
dc.date.accessioned	2024-03-28T00:41:35Z
dc.date.available	2024-03-28T00:41:35Z
dc.date.issued	2023-12-22
dc.identifier.citation	ACS Applied Nano Materials, 2023, 6, (24), pp. 23173-23183
dc.identifier.issn	2574-0970
dc.identifier.issn	2574-0970
dc.identifier.uri	http://hdl.handle.net/10453/177309
dc.description.abstract	Temperature is a basic physical parameter in living organisms that directly relates to the physiological state of the body. The demand for in vivo temperature detection is expected to obtain accurate temperature signals with high spatial resolution. We propose a strategy of constructing and encapsulating the temperature probe (NaNdF4:7%Yb,33%Y) and high-resolution imaging probe (NaYbF4:2%Er,2%Ce) in identical rare earth nanoparticles to attain in vivo temperature detection with high spatial resolution. The temperature probe acquires temperature feedback based on the luminescence lifetime signal which is used for accurate temperature acquisition with a thermal sensitivity of 1.94% K-1 and uncertainty of 0.05 K at 25.8 °C. The intensity-based imaging probe with emission wavelength in NIR-IIb is introduced to attain a high-resolution image with a signal-to-noise ratio of 2.5 times that of the temperature probe in NIR-I. Hence, the high-resolution image serves as the luminescence location image for the temperature distribution image attained by the temperature probe. On the basis of obtaining the temperature signal and high-resolution imaging signal, the image algorithm is designed for the superposition of the temperature image and high-resolution image. Ultimately, the dual-dimensional signals acquired by optical detection are superimposed by the image algorithm to obtain high-resolution temperature mapping.
dc.language	English
dc.publisher	AMER CHEMICAL SOC
dc.relation.ispartof	ACS Applied Nano Materials
dc.relation.isbasedon	10.1021/acsanm.3c04576
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	3106 Industrial biotechnology
dc.subject.classification	3403 Macromolecular and materials chemistry
dc.subject.classification	4018 Nanotechnology
dc.title	Nanothermometer for In Vivo Temperature Detection with High Spatial Resolution Based on Core-Shell Rare Earth Nanoparticles
dc.type	Journal Article
utslib.citation.volume	6
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2024-03-28T00:41:33Z
pubs.issue	24
pubs.publication-status	Published
pubs.volume	6
utslib.citation.issue	24

Abstract:

Temperature is a basic physical parameter in living organisms that directly relates to the physiological state of the body. The demand for in vivo temperature detection is expected to obtain accurate temperature signals with high spatial resolution. We propose a strategy of constructing and encapsulating the temperature probe (NaNdF4:7%Yb,33%Y) and high-resolution imaging probe (NaYbF4:2%Er,2%Ce) in identical rare earth nanoparticles to attain in vivo temperature detection with high spatial resolution. The temperature probe acquires temperature feedback based on the luminescence lifetime signal which is used for accurate temperature acquisition with a thermal sensitivity of 1.94% K-1 and uncertainty of 0.05 K at 25.8 °C. The intensity-based imaging probe with emission wavelength in NIR-IIb is introduced to attain a high-resolution image with a signal-to-noise ratio of 2.5 times that of the temperature probe in NIR-I. Hence, the high-resolution image serves as the luminescence location image for the temperature distribution image attained by the temperature probe. On the basis of obtaining the temperature signal and high-resolution imaging signal, the image algorithm is designed for the superposition of the temperature image and high-resolution image. Ultimately, the dual-dimensional signals acquired by optical detection are superimposed by the image algorithm to obtain high-resolution temperature mapping.

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http://hdl.handle.net/10453/177309