The contemplation of amylose for the delivery of ulcerogenic nonsteroidal anti-inflammatory drugs

Fatima, R; Prasher, P; Sharma, M; Singh, SK; Gupta, G; Dua, K

The contemplation of amylose for the delivery of ulcerogenic nonsteroidal anti-inflammatory drugs

Fatima, R Prasher, P Sharma, M Singh, SK Gupta, G Dua, K

Permalink

Publisher:: Informa UK Limited
Publication Type:: Journal Article
Citation:: Future Medicinal Chemistry

Closed Access

	Filename	Description	Size
	Amylose_NSAIDs_fmc-2024-0053-1.pdf	Published version	7.83 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Fatima, R
dc.contributor.author	Prasher, P
dc.contributor.author	Sharma, M
dc.contributor.author	Singh, SK
dc.contributor.author	Gupta, G
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2024-04-06T16:47:41Z
dc.date.available	2024-04-06T16:47:41Z
dc.identifier.citation	Future Medicinal Chemistry
dc.identifier.issn	1756-8919
dc.identifier.issn	1756-8927
dc.identifier.uri	http://hdl.handle.net/10453/177515
dc.description.abstract	<jats:p> This manuscript proposes an innovative approach to mitigate the gastrointestinal adversities linked with nonsteroidal anti-inflammatory drugs (NSAIDs) by exploiting amylose as a novel drug delivery carrier. The intrinsic attributes of V-amylose, such as its structural uniqueness, biocompatibility and biodegradability, as well as its capacity to form inclusion complexes with diverse drug molecules, are meticulously explored. Through a comprehensive physicochemical analysis of V-amylose and ulcerogenic NSAIDs, the plausibility of amylose as a protective carrier for ulcerogenic NSAIDs to gastrointestinal regions is elucidated. This review further discusses the potential therapeutic advantages of amylose-based drug delivery systems in the management of gastric ulcers. By providing controlled release kinetics and enhanced bioavailability, these systems offer promising prospects for the development of more effective ulcer therapies. </jats:p>
dc.language	en
dc.publisher	Informa UK Limited
dc.relation.ispartof	Future Medicinal Chemistry
dc.relation.isbasedon	10.4155/fmc-2024-0053
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0304 Medicinal and Biomolecular Chemistry, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.subject.classification	3404 Medicinal and biomolecular chemistry
dc.title	The contemplation of amylose for the delivery of ulcerogenic nonsteroidal anti-inflammatory drugs
dc.type	Journal Article
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2024-04-06T16:47:36Z
pubs.publication-status	Published online

Abstract:

This manuscript proposes an innovative approach to mitigate the gastrointestinal adversities linked with nonsteroidal anti-inflammatory drugs (NSAIDs) by exploiting amylose as a novel drug delivery carrier. The intrinsic attributes of V-amylose, such as its structural uniqueness, biocompatibility and biodegradability, as well as its capacity to form inclusion complexes with diverse drug molecules, are meticulously explored. Through a comprehensive physicochemical analysis of V-amylose and ulcerogenic NSAIDs, the plausibility of amylose as a protective carrier for ulcerogenic NSAIDs to gastrointestinal regions is elucidated. This review further discusses the potential therapeutic advantages of amylose-based drug delivery systems in the management of gastric ulcers. By providing controlled release kinetics and enhanced bioavailability, these systems offer promising prospects for the development of more effective ulcer therapies.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/177515