Spike and wave discharges detection in genetic absence epilepsy rat from Strasbourg and patients with genetic generalized epilepsy.
Li, R
Millist, L
Foster, E
Yuan, X
Guvenc, U
Radfar, M
Marendy, P
Ni, W
O'Brien, TJ
Casillas-Espinosa, PM
- Publisher:
- ELSEVIER
- Publication Type:
- Journal Article
- Citation:
- Epilepsy Res, 2023, 194, pp. 107181
- Issue Date:
- 2023-08
Closed Access
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1-s2.0-S0920121123001067-main.pdf | Published version | 2.4 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Li, R | |
dc.contributor.author | Millist, L | |
dc.contributor.author | Foster, E | |
dc.contributor.author |
Yuan, X https://orcid.org/0000-0002-9167-1613 |
|
dc.contributor.author | Guvenc, U | |
dc.contributor.author | Radfar, M | |
dc.contributor.author | Marendy, P | |
dc.contributor.author |
Ni, W https://orcid.org/0000-0002-4933-594X |
|
dc.contributor.author | O'Brien, TJ | |
dc.contributor.author | Casillas-Espinosa, PM | |
dc.date.accessioned | 2024-04-17T02:03:48Z | |
dc.date.available | 2023-06-13 | |
dc.date.available | 2024-04-17T02:03:48Z | |
dc.date.issued | 2023-08 | |
dc.identifier.citation | Epilepsy Res, 2023, 194, pp. 107181 | |
dc.identifier.issn | 0920-1211 | |
dc.identifier.issn | 1872-6844 | |
dc.identifier.uri | http://hdl.handle.net/10453/177998 | |
dc.description.abstract | OBJECTIVE: Generalised spike and wave discharges (SWDs) are pathognomonic EEG signatures for diagnosing absence seizures in patients with Genetic Generalized Epilepsy (GGE). The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is one of the best-validated animal models of GGE with absence seizures. METHODS: We developed an SWDs detector for both GAERS rodents and GGE patients with absence seizures using a neural network method. We included 192 24-hour EEG sessions recorded from 18 GAERS rats, and 24-hour scalp-EEG data collected from 11 GGE patients. RESULTS: The SWDs detection performance on GAERS showed a sensitivity of 98.01% and a false positive (FP) rate of 0.96/hour. The performance on GGE patients showed 100% sensitivity in five patients, while the remaining patients obtained over 98.9% sensitivity. Moderate FP rates were seen in our patients with 2.21/hour average FP. The detector trained within our patient cohort was validated in an independent dataset, TUH EEG Seizure Corpus (TUSZ), that showed 100% sensitivity in 11 of 12 patients and 0.56/hour averaged FP. CONCLUSIONS: We developed a robust SWDs detector that showed high sensitivity and specificity for both GAERS rats and GGE patients. SIGNIFICANCE: This detector can assist researchers and neurologists with the time-efficient and accurate quantification of SWDs. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | ELSEVIER | |
dc.relation.ispartof | Epilepsy Res | |
dc.relation.isbasedon | 10.1016/j.eplepsyres.2023.107181 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 1103 Clinical Sciences | |
dc.subject.classification | Neurology & Neurosurgery | |
dc.subject.classification | 3209 Neurosciences | |
dc.subject.classification | 5202 Biological psychology | |
dc.subject.classification | 5203 Clinical and health psychology | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Epilepsy, Absence | |
dc.subject.mesh | Rats, Wistar | |
dc.subject.mesh | Epilepsy, Generalized | |
dc.subject.mesh | Seizures | |
dc.subject.mesh | Electroencephalography | |
dc.subject.mesh | Disease Models, Animal | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, Wistar | |
dc.subject.mesh | Epilepsy, Generalized | |
dc.subject.mesh | Epilepsy, Absence | |
dc.subject.mesh | Seizures | |
dc.subject.mesh | Disease Models, Animal | |
dc.subject.mesh | Electroencephalography | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Epilepsy, Absence | |
dc.subject.mesh | Rats, Wistar | |
dc.subject.mesh | Epilepsy, Generalized | |
dc.subject.mesh | Seizures | |
dc.subject.mesh | Electroencephalography | |
dc.subject.mesh | Disease Models, Animal | |
dc.title | Spike and wave discharges detection in genetic absence epilepsy rat from Strasbourg and patients with genetic generalized epilepsy. | |
dc.type | Journal Article | |
utslib.citation.volume | 194 | |
utslib.location.activity | Netherlands | |
utslib.for | 1103 Clinical Sciences | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2024-04-17T02:03:47Z | |
pubs.publication-status | Published | |
pubs.volume | 194 |
Abstract:
OBJECTIVE: Generalised spike and wave discharges (SWDs) are pathognomonic EEG signatures for diagnosing absence seizures in patients with Genetic Generalized Epilepsy (GGE). The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is one of the best-validated animal models of GGE with absence seizures. METHODS: We developed an SWDs detector for both GAERS rodents and GGE patients with absence seizures using a neural network method. We included 192 24-hour EEG sessions recorded from 18 GAERS rats, and 24-hour scalp-EEG data collected from 11 GGE patients. RESULTS: The SWDs detection performance on GAERS showed a sensitivity of 98.01% and a false positive (FP) rate of 0.96/hour. The performance on GGE patients showed 100% sensitivity in five patients, while the remaining patients obtained over 98.9% sensitivity. Moderate FP rates were seen in our patients with 2.21/hour average FP. The detector trained within our patient cohort was validated in an independent dataset, TUH EEG Seizure Corpus (TUSZ), that showed 100% sensitivity in 11 of 12 patients and 0.56/hour averaged FP. CONCLUSIONS: We developed a robust SWDs detector that showed high sensitivity and specificity for both GAERS rats and GGE patients. SIGNIFICANCE: This detector can assist researchers and neurologists with the time-efficient and accurate quantification of SWDs.
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